NOAEL Studies Cosmetic Ingredient

Cupric Oxide NOAEL Studies

INCI: CUPRIC OXIDE

CAS: 1317-38-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =10 mg/day Human oral: unspecified 84 days study with volunteers EFSA FEEDAP - 2015 - OutputID 2631 - clinical chemistry - hepatotoxicity - Scientific Opinion on the safety and efficacy of copper compounds (E4) as feed additives for all animal species (cupric acetate, monohydrate; basic cupric carbonate, monohydrate; cupric chloride, dihydrate; cupric oxide; cupric sulphate, pentahydrate; cupric chelate of amino acids, hydrate; cupric chelate of glycine, hydrate), based on a dossier submitted by FEFANA asbl - doi:10.2903/j.efsa.2015.4057
EFSA NOAEL =10 mg/day Human oral: unspecified 84 days study with volunteers EFSA FEEDAP - 2015 - OutputID 2631 - clinical chemistry - hepatotoxicity - Scientific Opinion on the safety and efficacy of copper compounds (E4) as feed additives for all animal species (cupric acetate, monohydrate; basic cupric carbonate, monohydrate; cupric chloride, dihydrate; cupric oxide; cupric sulphate, pentahydrate; cupric chelate of amino acids, hydrate; cupric chelate of glycine, hydrate), based on a dossier submitted by FEFANA asbl - doi:10.2903/j.efsa.2015.4057
EFSA NOAEL =10 mg/day Human oral subchronic; 12 weeks clinical LONG_REF=EFSA FEEDAP (2015). Scientific Opinion on the safety and efficacy of copper compounds (E4) as feed additives for all animal species (cupric acetate, monohydrate; basic cupric carbonate, monohydrate; cupric chloride, dihydrate; cupric oxide; cupric sulphate, pentahydrate; cupric chelate of amino acids, hydrate; cupric chelate of glycine, hydrate), based on a dossier submitted by FEFANA asbl. doi:10.2903/j.efsa.2015.4057.; TITLE=Scientific Opinion on the safety and efficacy of copper compounds (E4) as feed additives for all animal species (cupric acetate, monohydrate; basic cupric carbonate, monohydrate; cupric chloride, dihydrate; cupric oxide; cupric sulphate, pentahydrate; cupric chelate of amino acids, hydrate; cupric chelate of glycine, hydrate), based on a dossier submitted by FEFANA asbl; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2015.4057; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15614360:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e6d0758ff01a0a57b45043ed8bb9b89
ToxValDB Copper Manufacturers 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Copper Manufacturers LOAEL =5 mg/L Human oral subchronic; 9 weeks clinical LONG_REF=Pizarro F., Olivares M., Araya M., Gidi V., Uauy R. (2001) Gastrointestinal effects associated with soluble and insoluble copper in drinking water. Environ Health Perspect 109(9):949; TITLE=Gastrointestinal effects associated with soluble and insoluble copper in drinking water.; AUTHOR=Pizarro F., Olivares M., Araya M., Gidi V., Uauy R.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/638f996de4b04f6bb1497234; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://ehp.niehs.nih.gov/doi/10.1289/ehp.01109949; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=gastrointestinal effects; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Copper Manufacturers:15498043:F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_809f3c7e0aab5598602804ca59cc6ea4
ECHA 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =156 mg/kg bw/day Rat oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca69e4b0a7c65d221ae5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/6/2?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833116_15833117:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6ba2bec356840bee60469c8073d57f6
ECHA LOAEL =370 mg/kg bw/day Mouse oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca69e4b0a7c65d221af7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/6/2?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837860_15837861:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7b5e906c277cdafcad1e57526c7de0a0
ECHA LOAEL >1500 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bce4b0a7c65d219d83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/9/2?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855150_15856668:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96c055827b66f36d297c097018ff93b1
ECHA LOEL =0.2 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/6/3?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827680_15827681:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8d285d650cf6ab9d8fced282204dfbc
ECHA NOAEL >=2 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/6/3?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827680_15827681:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50f2cacb8b8036881b4e58d64a2724a3
ECHA NOAEL =78 mg/kg bw/day Rat oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca69e4b0a7c65d221ae5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/6/2?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833116_15833117:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_206dee7baa11c34193a5e267d7a6fa80
ECHA NOAEL =185 mg/kg bw/day Mouse oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca69e4b0a7c65d221af7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/6/2?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837860_15837861:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df2a45be03b791b935cbe9414c340a57
ECHA NOAEL =1000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bce4b0a7c65d219d83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24398/7/9/2?documentUUID=4229a864-c4f9-4cac-930e-00420479aaab; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856025_15856850:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2cd46b1134435f24f57ba4a121b02e5
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630819_15630820:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9ab17d622806f52530d19fe106d0e693
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier V1XJQ704R4 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cu.O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V1XJQ704R4"}
openFDA substances FDA UNII substance identifier V1XJQ704R4 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cu.O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V1XJQ704R4"}
openFDA substances FDA UNII substance identifier V1XJQ704R4 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cu.O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V1XJQ704R4"}
openFDA substances FDA UNII substance identifier V1XJQ704R4 UNII - - - chemical {"approval_status":null,"molecular_formula":"Cu.O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V1XJQ704R4"}