Moderate Cosmetic Ingredient NOAEL Data

Curcuma Longa Callus Extract

INCI: CURCUMA LONGA CALLUS EXTRACT

CAS Number
84775-52-0
Function
Antioxidant, skin conditioning, skin protecting, anti-aging
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA: no specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Curcuma Longa Callus Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 75 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
NOAEL 250 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 75 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
dose_tested 250 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Plant callus extract with antioxidant properties; differentiate from rhizome extracts by specifying extraction solvent residues and confirming polysaccharide/amino acid composition with supplier.

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Concern Level: Moderate

Regulatory Flags

plant-extract fda_food_additive

Frequently Asked Questions

Is Curcuma Longa Callus Extract safe in cosmetics?

Plant callus extract with antioxidant properties; differentiate from rhizome extracts by specifying extraction solvent residues and confirming polysaccharide/amino acid composition with supplier. The EU classifies Curcuma Longa Callus Extract as "permitted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is Curcuma Longa Callus Extract allowed in the EU?

Curcuma Longa Callus Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Curcuma Longa Callus Extract do in cosmetics?

Curcuma Longa Callus Extract functions as: Antioxidant, skin conditioning, skin protecting, anti-aging. It is classified as a cosmetic ingredient in our database. CAS number: 84775-52-0.

What is the Margin of Safety for Curcuma Longa Callus Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Curcuma Longa Callus Extract?

The NOAEL (No Observed Adverse Effect Level) for Curcuma Longa Callus Extract is 75 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 4 study endpoints are available. Source: COSMOS_DB.

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