Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA)

INCI: CYCLIC LYSOPHOSPHATIDIC ACID

CAS Number
Not clearly standardized for cosmetic grade NcPA in public sources; typically proprietary lipid active (screening judgement)
Function
Skin-conditioning active; increases skin hydration by upregulating hyaluronic acid synthesis and improving elasticity
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA monograph; used in cosmetic anti-aging serums at low levels (approximately 0.1%) with safety supported by sponsor data

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited public toxicology data; safety supported by sponsor studies; monitor for irritation when combined with other active ingredients; typical lipid-active considerations apply for long-term use.

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Concern Level: Low

Frequently Asked Questions

Is Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA) safe in cosmetics?

Limited public toxicology data; safety supported by sponsor studies; monitor for irritation when combined with other active ingredients; typical lipid-active considerations apply for long-term use. The EU classifies Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA) as "permitted". Safety rating: GOOD.

Is Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA) allowed in the EU?

Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA) do in cosmetics?

Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA) functions as: Skin-conditioning active; increases skin hydration by upregulating hyaluronic acid synthesis and improving elasticity. It is classified as a cosmetic ingredient in our database. CAS number: Not clearly standardized for cosmetic grade NcPA in public sources; typically proprietary lipid active (screening judgement).

What is the Margin of Safety for Cyclic Lysophosphatidic Acid (e.g., Sodium Cyclic Lysophosphatidic Acid, NcPA)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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