Moderate Cosmetic Ingredient

Cyclohexadecanol

INCI: CYCLOHEXADECANOL

CAS Number
Not clearly established as a cosmetic ingredient; multiple long-chain cycloalkanols exist with similar names and overlapping identifiers, so CAS for cosmetic use is not reliably defined from current public cosmetic databases.
Function
Fragrance, Emollient
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific FDA cosmetic or CIR monograph identified; defaults to general use under conditions of safe use with manufacturer-responsible safety substantiation.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Cyclohexadecanol lacks a robust cosmetic toxicological dossier and established safety data; full safety substantiation including skin irritation, sensitization, repeated dose, reproductive/developmental, and environmental assessment required before routine cosmetic use.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Cyclohexadecanol safe in cosmetics?

Cyclohexadecanol lacks a robust cosmetic toxicological dossier and established safety data; full safety substantiation including skin irritation, sensitization, repeated dose, reproductive/developmental, and environmental assessment required before routine cosmetic use. The EU classifies Cyclohexadecanol as "permitted". Safety rating: MODERATE.

Is Cyclohexadecanol allowed in the EU?

Cyclohexadecanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cyclohexadecanol do in cosmetics?

Cyclohexadecanol functions as: Fragrance, Emollient. It is classified as a cosmetic ingredient in our database. CAS number: Not clearly established as a cosmetic ingredient; multiple long-chain cycloalkanols exist with similar names and overlapping identifiers, so CAS for cosmetic use is not reliably defined from current public cosmetic databases..

What is the Margin of Safety for Cyclohexadecanol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Cyclohexadecanol compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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