NOAEL Studies
Cosmetic Ingredient
Cyclohexylamine NOAEL Studies
INCI: CYCLOHEXYLAMINE
CAS: 108‑91‑8 (primary alicyclic amine used industrially as intermediate and corrosion inhibitor).
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 27 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | ca.50 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=d43d1b93-5f9b-4382-b9d6-b022624ea88e_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=d43d1b93-5f9b-4382-b9d6-b022624ea88e/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1971; basis=other:; key_result=false; entry_uuid=a12cf7d3-95d1-44f7-837e-70178dd47775 |
| ECHA | NOAEL | ca.42 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=c7ee5e8c-065d-4c76-9c70-023781c182b5_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=c7ee5e8c-065d-4c76-9c70-023781c182b5/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=063de4df-e97e-45e8-b2e7-1bf0c7617989 |
| ECHA | NOAEL | ca.15 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=dc31aed0-5bd5-4752-b5c1-34c13d66d4e9_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=dc31aed0-5bd5-4752-b5c1-34c13d66d4e9/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; basis=other:; key_result=true; entry_uuid=9940b70c-5e41-422f-91b9-8edb9239470d |
| ECHA | NOAEL | ca.140 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=8fe0c8c2-1f91-4895-997f-4d82ea7f029a_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=8fe0c8c2-1f91-4895-997f-4d82ea7f029a/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=5431ee07-37e9-488b-ae82-a65edd65909a |
| ECHA | NOAEL | 100 | mg/kg bw/day | rat | oral: feed | - | toxicity to reproduction: other studies | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4de7c415-dda5-4ddb-8f65-4bc271a181b5_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4de7c415-dda5-4ddb-8f65-4bc271a181b5/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=1978; basis=other:; key_result=false; entry_uuid=3f7a05e8-e198-4c13-9e68-d8ded87466bd |
| ECHA | NOAEL | ca.18 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=de0ad389-0e4f-4bb6-9a42-152d58c329e9 |
| ECHA | NOAEL | ca.36 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=709a4077-cf17-4232-86f5-43dc45928ef5 |
| ECHA | NOAEL | >=34 | mg/kg bw/day | monkey | oral: capsule | - | toxicity to reproduction: other studies | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=5e381767-6b7a-433b-95c9-28a604d32268_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=5e381767-6b7a-433b-95c9-28a604d32268/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; upper_value=100; entry_uuid=45786524-5865-416b-8187-bf0d13943d5d |
| ECHA | NOAEL | >=1.5 | mg/kg bw/day | other: | oral: unspecified | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=6f13f58a-0ac6-4071-b773-f550ef226e34_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=6f13f58a-0ac6-4071-b773-f550ef226e34/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1969; basis=other:; key_result=false; upper_value=15; entry_uuid=f4eebe4e-c3dc-4396-a199-edd5e0d48246 |
| ECHA | NOAEL | ca.50 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=d43d1b93-5f9b-4382-b9d6-b022624ea88e_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=d43d1b93-5f9b-4382-b9d6-b022624ea88e/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1971; basis=other:; key_result=false; entry_uuid=a12cf7d3-95d1-44f7-837e-70178dd47775 |
| ECHA | NOAEL | ca.42 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=c7ee5e8c-065d-4c76-9c70-023781c182b5_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=c7ee5e8c-065d-4c76-9c70-023781c182b5/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=063de4df-e97e-45e8-b2e7-1bf0c7617989 |
| ECHA | NOAEL | ca.15 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=dc31aed0-5bd5-4752-b5c1-34c13d66d4e9_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=dc31aed0-5bd5-4752-b5c1-34c13d66d4e9/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; basis=other:; key_result=true; entry_uuid=9940b70c-5e41-422f-91b9-8edb9239470d |
| ECHA | NOAEL | ca.140 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=8fe0c8c2-1f91-4895-997f-4d82ea7f029a_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=8fe0c8c2-1f91-4895-997f-4d82ea7f029a/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=5431ee07-37e9-488b-ae82-a65edd65909a |
| ECHA | NOAEL | 100 | mg/kg bw/day | rat | oral: feed | - | toxicity to reproduction: other studies | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4de7c415-dda5-4ddb-8f65-4bc271a181b5_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4de7c415-dda5-4ddb-8f65-4bc271a181b5/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=1978; basis=other:; key_result=false; entry_uuid=3f7a05e8-e198-4c13-9e68-d8ded87466bd |
| ECHA | NOAEL | ca.18 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=de0ad389-0e4f-4bb6-9a42-152d58c329e9 |
| ECHA | NOAEL | ca.36 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=709a4077-cf17-4232-86f5-43dc45928ef5 |
| ECHA | NOAEL | >=34 | mg/kg bw/day | monkey | oral: capsule | - | toxicity to reproduction: other studies | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=5e381767-6b7a-433b-95c9-28a604d32268_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=5e381767-6b7a-433b-95c9-28a604d32268/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; upper_value=100; entry_uuid=45786524-5865-416b-8187-bf0d13943d5d |
| ECHA | NOAEL | >=1.5 | mg/kg bw/day | other: | oral: unspecified | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=6f13f58a-0ac6-4071-b773-f550ef226e34_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=6f13f58a-0ac6-4071-b773-f550ef226e34/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1969; basis=other:; key_result=false; upper_value=15; entry_uuid=f4eebe4e-c3dc-4396-a199-edd5e0d48246 |
| ECHA | NOAEL | ca.50 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=d43d1b93-5f9b-4382-b9d6-b022624ea88e_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=d43d1b93-5f9b-4382-b9d6-b022624ea88e/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1971; basis=other:; key_result=false; entry_uuid=a12cf7d3-95d1-44f7-837e-70178dd47775 |
| ECHA | NOAEL | ca.42 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=c7ee5e8c-065d-4c76-9c70-023781c182b5_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=c7ee5e8c-065d-4c76-9c70-023781c182b5/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=063de4df-e97e-45e8-b2e7-1bf0c7617989 |
| ECHA | NOAEL | ca.15 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=dc31aed0-5bd5-4752-b5c1-34c13d66d4e9_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=dc31aed0-5bd5-4752-b5c1-34c13d66d4e9/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; basis=other:; key_result=true; entry_uuid=9940b70c-5e41-422f-91b9-8edb9239470d |
| ECHA | NOAEL | ca.140 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=8fe0c8c2-1f91-4895-997f-4d82ea7f029a_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=8fe0c8c2-1f91-4895-997f-4d82ea7f029a/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=5431ee07-37e9-488b-ae82-a65edd65909a |
| ECHA | NOAEL | 100 | mg/kg bw/day | rat | oral: feed | - | toxicity to reproduction: other studies | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4de7c415-dda5-4ddb-8f65-4bc271a181b5_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4de7c415-dda5-4ddb-8f65-4bc271a181b5/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=1978; basis=other:; key_result=false; entry_uuid=3f7a05e8-e198-4c13-9e68-d8ded87466bd |
| ECHA | NOAEL | ca.18 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=de0ad389-0e4f-4bb6-9a42-152d58c329e9 |
| ECHA | NOAEL | ca.36 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=4f1aa5e2-cb6a-4b09-8225-dbb389b3fdfc/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1973; basis=other:; key_result=false; entry_uuid=709a4077-cf17-4232-86f5-43dc45928ef5 |
| ECHA | NOAEL | >=34 | mg/kg bw/day | monkey | oral: capsule | - | toxicity to reproduction: other studies | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=5e381767-6b7a-433b-95c9-28a604d32268_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=5e381767-6b7a-433b-95c9-28a604d32268/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; upper_value=100; entry_uuid=45786524-5865-416b-8187-bf0d13943d5d |
| ECHA | NOAEL | >=1.5 | mg/kg bw/day | other: | oral: unspecified | - | developmental toxicity | dossier=8c3da020-296d-471d-a0be-0576bf303235.i6z; document=6f13f58a-0ac6-4071-b773-f550ef226e34_8c3da020-296d-471d-a0be-0576bf303235.i6d; document_key=6f13f58a-0ac6-4071-b773-f550ef226e34/8c3da020-296d-471d-a0be-0576bf303235; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1969; basis=other:; key_result=false; upper_value=15; entry_uuid=f4eebe4e-c3dc-4396-a199-edd5e0d48246 |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =18 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=199283ee82c9bbe7; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.8e1 mg/kg-day; system=Reproductive; basis=Testicular damage; point_of_departure=NOAEL : 1.8e1 mg/kg-day; composite_uf=100; confidence=High; dtxsid=DTXSID1023996; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=319; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0319_summary.pdf |
| Regulatory source | RfD | =0.2 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=3d23f01f1c21ef7d; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2e-1; system=Reproductive; basis=Testicular damage; point_of_departure=NOAEL : 1.8e1 mg/kg-day; composite_uf=100; confidence=High; dtxsid=DTXSID1023996; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=319; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0319_summary.pdf |
NTP ICE acute inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 7.5 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=908; Record_ID=acute_inhalation_1148; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.5; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE acute inhalation | LC50 | 7.4874 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=909; Record_ID=acute_inhalation_1916; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.4874; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =11 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_795; row=2404; data_type=In Vivo; mixture=Chemical; chemical_name=Cyclohexylamine; preferred_name=Cyclohexylamine; dtxsid=DTXSID1023996; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1023996; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =156 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_796; row=2405; data_type=In Vivo; mixture=Chemical; chemical_name=Cyclohexylamine; preferred_name=Cyclohexylamine; dtxsid=DTXSID1023996; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1023996; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7194; RecordID=ARPathway2016_520; DatasetName=ARPathway2016; DTXSID=DTXSID1023996; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
NTP ICE skin irritation 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 43.3 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=968; Record_ID=skin_irritation_invitro_42; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=Corrositex; Endpoint=Breakthrough Time; Response=43.3; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Breakthrough Time | 48.7 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=970; Record_ID=skin_irritation_invitro_44; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=Corrositex; Endpoint=Breakthrough Time; Response=48.7; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Breakthrough Time | 42.79 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=972; Record_ID=skin_irritation_invitro_92; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=Corrositex; Endpoint=Breakthrough Time; Response=42.79; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Breakthrough Time | 41 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=974; Record_ID=skin_irritation_invitro_95; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=Corrositex; Endpoint=Breakthrough Time; Response=41; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | TER | 1.1 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=956; Record_ID=skin_irritation_invitro_2540; Data_Type=In Vitro; Concentration=11.9; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=TER Corrosion; Endpoint=TER; Response=1.1; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | TER | 1.5 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=957; Record_ID=skin_irritation_invitro_2541; Data_Type=In Vitro; Concentration=11.9; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=TER Corrosion; Endpoint=TER; Response=1.5; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (240 minutes) | 8.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=953; Record_ID=skin_irritation_invitro_1904; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=8.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (240 minutes) | 18.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=954; Record_ID=skin_irritation_invitro_1905; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=18.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (240 minutes) | 10.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=955; Record_ID=skin_irritation_invitro_1906; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=10.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (3 minutes) | 46.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=962; Record_ID=skin_irritation_invitro_1905; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=46.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (3 minutes) | 89.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=963; Record_ID=skin_irritation_invitro_1904; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=89.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (3 minutes) | 73.9 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=976; Record_ID=skin_irritation_invitro_1906; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=73.90; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (60 minutes) | 9.2 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=960; Record_ID=skin_irritation_invitro_1906; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=9.20; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (60 minutes) | 13.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=961; Record_ID=skin_irritation_invitro_1904; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=13.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
| NTP ICE skin irritation | Viability (60 minutes) | 3.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=965; Record_ID=skin_irritation_invitro_1905; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1023996; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=3.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023996; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1023996 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =60845.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=DOE Protective Action Criteria:15514042:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_986b85483924333626c50dee2c3b1da6 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =426 | ppm | Rat | oral | acute; 0.875 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.9(5): 273-285 Kitchin,K.T., and J.L. Brown Biochemical Studies of Promoters of Carcinogenesis in Rat Liver 1989; TITLE=Biochemical Studies of Promoters of Carcinogenesis in Rat Liver; AUTHOR=Kitchin,K.T., and J.L. Brown; DOI=10.1002/tcm.1770090503; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=103823; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Enzyme(s): Ornithine decarboxylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15603634:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a17eb1b40bbe329923150a9613e147cc |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630878:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f8f9b3cd7aa1b438e4906aa7fd82cff8 |
ToxValDB IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =60 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Gaunt, I.F., J. Hardy, P. Grasso, S.D. Gangolli and K.R. Butterworth. 1976. Long-term toxicity of cyclohexylamine hydrochloride in the rat. Food Cosmet. Toxicol. 14(4): 255-268.; TITLE=Long-term toxicity of cyclohexylamine hydrochloride in the rat; AUTHOR=Gaunt, I.F., J. Hardy, P. Grasso, S.D. Gangolli and K.R. Butterworth; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a573c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=319; TOXICOLOGICAL_EFFECT=testicular damage; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15645507_15645511:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1bcf365ac7cd171e1b091155094feacd |
| ToxValDB IRIS | NOAEL | =18 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Gaunt, I.F., J. Hardy, P. Grasso, S.D. Gangolli and K.R. Butterworth. 1976. Long-term toxicity of cyclohexylamine hydrochloride in the rat. Food Cosmet. Toxicol. 14(4): 255-268.; TITLE=Long-term toxicity of cyclohexylamine hydrochloride in the rat; AUTHOR=Gaunt, I.F., J. Hardy, P. Grasso, S.D. Gangolli and K.R. Butterworth; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a573c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=319; TOXICOLOGICAL_EFFECT=testicular damage; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15645507_15645511:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2be399b03b0db0eb02ce407004e926ae |
| ToxValDB IRIS | RfD | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Gaunt, I.F., J. Hardy, P. Grasso, S.D. Gangolli and K.R. Butterworth. 1976. Long-term toxicity of cyclohexylamine hydrochloride in the rat. Food Cosmet. Toxicol. 14(4): 255-268.; TITLE=Long-term toxicity of cyclohexylamine hydrochloride in the rat; AUTHOR=Gaunt, I.F., J. Hardy, P. Grasso, S.D. Gangolli and K.R. Butterworth; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a573c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=319; TOXICOLOGICAL_EFFECT=Testicular damage in male rats; STUDY_GROUP=IRIS:15644655:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3448bbc0e87ff9ab60ca7b3fa5b886ae |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfD | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663327:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_638a6bbc28e4f53f3ea14c4f50b33c6c |