NOAEL Studies
Cosmetic Ingredient
Cyclotetrasiloxane NOAEL Studies
INCI: CYCLOTETRASILOXANE
CAS: 556-67-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 60 | mg/kg bw/day | mouse | oral | 2 year | Chronic | REACH; Toxicol. Sci., 71, 198-206 |
| COSMOS DB | LOAEL | 210 | mg/kg bw/day | rat | oral | 2 year | Chronic | REACH; Toxicol. Sci., 71, 198-206 |
| COSMOS DB | LOAEL | 335 | mg/kg bw/day | rat | oral | 14 week | Subchronic | REACH; Toxicol. Sci., 71, 198-206 |
| COSMOS DB | LOAEL | 745 | mg/kg bw/day | mouse | oral | 14 week | Subchronic | REACH; Toxicol. Sci., 71, 198-206 |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | rat | oral | 2 year | Chronic | REACH; Toxicol. Sci., 71, 198-206 |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 36 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4007; Record_ID=acute_inhalation_1234; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7027205; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=36; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1540 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_7637; row=12036; data_type=In Vivo; mixture=Chemical; chemical_name=Octamethylcyclotetrasiloxane; preferred_name=Octamethylcyclotetrasiloxane; dtxsid=DTXSID7027205; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >4800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_7639; row=12034; data_type=In Vivo; mixture=Chemical; chemical_name=Octamethylcyclotetrasiloxane; preferred_name=Octamethylcyclotetrasiloxane; dtxsid=DTXSID7027205; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >61440 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_7641; row=12035; data_type=In Vivo; mixture=Chemical; chemical_name=Octamethylcyclotetrasiloxane; preferred_name=Octamethylcyclotetrasiloxane; dtxsid=DTXSID7027205; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205; source_file=acute_oral.xlsx |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | LOEL | 250 | mg/kg bw/day | Rat | Oral | Treatment_Duration=4 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 24 hours; Number_of_Doses_Tested=2 to 6 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=864; Record_ID=endocrine_invivo_209; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7027205; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=250; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=F-344 [COBS CDF (F-344/CrlBR)]; Strain=Fischer; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=McKim et al. 2001; 11509742; 10.1093/toxsci/63.1.37|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12542; RecordID=ARPathway2016_1326; DatasetName=ARPathway2016; DTXSID=DTXSID7027205; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205 |
| NTP ICE endocrine | Uterine weight increase vs control | 150 | % | Rat | Oral | Treatment_Duration=4 days; Age_at_First_Dose=PND 18; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 24 hours; Number_of_Doses_Tested=2 to 6 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=544; Record_ID=endocrine_invivo_207; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7027205; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=150; Response_Unit=%; Species=Rat; Reported_Strain=SD (Cr:CD VAF/Plus); Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=McKim et al. 2001; 11509742; 10.1093/toxsci/63.1.37|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205 |
| NTP ICE endocrine | Uterine weight increase vs control | 160 | % | Mouse | Oral | Treatment_Duration=3 days; Age_at_First_Dose=PND 63 to 70; Age_Ovariectomized_or_Castrated=PND 42 to 49; Time_Elapsed_Between_Surgery_and_Treatment=14 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=7 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=546; Record_ID=endocrine_invivo_211; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7027205; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=160; Response_Unit=%; Species=Mouse; Reported_Strain=B6C3F1; Strain=B6C3F1; Sex=Female (ovariectomized); Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=He et al. 2003; 14575643; 10.1016/s0041-008x(03)00282-5|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027205 |
SCCS Opinion 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.1 | mg/kg bw/day | rat | dermal | 5 days | dermal absorption | p.99 |
| SCCS Opinion | NOAEL | =0.2 | mg/kg bw/day | rat | oral | - | NOAEL study | p.100 |
| SCCS Opinion | NOAEL | =4 | - | rat | inhalation | 90-day | reproductive toxicity | p.60 |
| SCCS Opinion | NOAEL | =5 | ppm | rat | inhalation | 14- day | NOAEL study | p.72 |
| SCCS Opinion | NOAEL | =10 | ppm | rat | - | 13 week | NOAEL study | p.22 |
| SCCS Opinion | NOAEL | =11 | - | - | - | - | NOAEL study | p.97 |
| SCCS Opinion | NOAEL | =17.8 | mg/kg bw/day | rat | oral | - | NOAEL study | p.100 |
| SCCS Opinion | NOAEL | =35 | ppm | rat | - | chronic | NOAEL study | Ref.: 15, AR 3 3, p.24 |
| SCCS Opinion | NOAEL | =50 | ppm | rat | inhalation | 13 weeks | NOAEL study | p.23 |
| SCCS Opinion | NOAEL | =52 | % | rat | oral | - | NOAEL study | p.100 |
| SCCS Opinion | NOAEL | =70 | ppm | rat | oral | - | NOAEL study | p.55 |
| SCCS Opinion | NOAEL | =80 | - | - | - | - | reproductive toxicity | p.80 |
| SCCS Opinion | NOAEL | =100 | mg/kg | rat | oral | 13-week | NOAEL study | p.70 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw | rat | oral | 5 day | repeated dose toxicity | p.73 |
| SCCS Opinion | NOAEL | >132 | ppm | - | - | - | NOAEL study | p.78 |
| SCCS Opinion | NOAEL | =150 | ppm | - | - | 12 months | NOAEL study | Ref.: 37 (submission II), AR 4, p.25 |
| SCCS Opinion | NOAEL | =150 | ppm | rabbit | oral | 12 months | repeated dose toxicity | p.28 |
| SCCS Opinion | NOAEL | =160 | ppm | rat | - | developmental | reproductive toxicity | p.80 |
| SCCS Opinion | NOAEL | <226 | ppm | mouse | - | - | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | <226 | ppm | mouse | inhalation | 28 days | NOAEL study | p.23 |
| SCCS Opinion | NOAEL | =300 | ppm | rat | inhalation | developmental | reproductive toxicity | Ref.: 22, 23, 24, 25, 26 3, p.32 |
| SCCS Opinion | NOAEL | =700 | ppm | rat | - | chronic | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =960 | mg/kg | rat | inhalation | 14-day | repeated dose toxicity | p.17 |
| SCCS Opinion | NOAEL | =960 | mg/kg bw | rabbit | oral | 6 months | repeated dose toxicity | p.28 |
| SCCS Opinion | NOAEL | =1600 | mg/kg bw | rat | oral | 4 weeks | repeated dose toxicity | (Ref. 4), p.73 |
ToxValDB EPA TSCA 8e 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =849.212 | mg/m3 | Rat | inhalation | chronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/89960000183_556672_0500883D6704261485256930004F3161.pdf; TOXICOLOGICAL_EFFECT=P0: increase in the number of pups born dead; STUDY_GROUP=EPA TSCA 8e_dup_-_15957299_15957300:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ba15f2180b702fa42347b2d71e50d3ca |
| ToxValDB EPA TSCA 8e | LEL | =8492.12 | mg/m3 | Rat | inhalation | chronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/89960000183_556672_0500883D6704261485256930004F3161.pdf; TOXICOLOGICAL_EFFECT=P0: decrease in number of implantation sties, decrease in mean viable litter size; STUDY_GROUP=EPA TSCA 8e_dup_-_15957299_15957300:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3837d819f1b709e1da0fd1d0b8ce89fb |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =73 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633879_15633880:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e51dce20e7da08e34bded831867cea29 |
ToxValDB Uterotrophic Hershberger DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | LEL | =250 | mg/kg bw/day | Rat | oral | short-term; 4 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713652:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cfb13207d9d47daab7a9076f17d8955e |
| ToxValDB Uterotrophic Hershberger DB | LEL | =1000 | mg/kg bw/day | Mouse | oral | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713653_15713684:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca1605e5c896c23b23e593dccc21367f |
Regulatory source 52 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | =0.1 | mg/kg bw/day | rat | oral | - | - | p.100 |
| Regulatory source | - | =0.2 | mg/kg bw/day | rat | oral | - | - | p.100 |
| Regulatory source | - | 5 | ppm | rat | inhalation | 14- day | - | p.72 |
| Regulatory source | - | 5 | % | rat | inhalation | 5 days | - | p.99 |
| Regulatory source | - | 10 | ppm | rat | - | 13 week | - | p.22 |
| Regulatory source | - | 10 | ppm | - | - | 12 months | - | p.25 |
| Regulatory source | - | 11 | - | - | - | - | - | p.97 |
| Regulatory source | - | =17.8 | mg/kg bw/day | rat | oral | - | - | p.100 |
| Regulatory source | - | 35 | ppm | rat | - | chronic | - | p.24 |
| Regulatory source | - | 50 | ppm | rat | inhalation | 13 weeks | - | p.23 |
| Regulatory source | - | 52 | % | rat | oral | - | - | p.100 |
| Regulatory source | - | 70 | ppm | rat | oral | - | - | p.55 |
| Regulatory source | - | 100 | mg/kg | rat | oral | 13-week | - | p.70 |
| Regulatory source | - | >132 | ppm | - | - | - | - | p.78 |
| Regulatory source | - | 150 | ppm | - | - | 12 months | - | p.25 |
| Regulatory source | - | 150 | ppm | rat | - | - | - | p.30 |
| Regulatory source | - | 150 | ppm | rat | - | chronic | - | p.62 |
| Regulatory source | - | 150 | ppm | rat | inhalation | 5 days | - | p.99 |
| Regulatory source | - | 150 | ppm | - | oral | - | - | p.100 |
| Regulatory source | - | 150 | ppm | rat | inhalation | 3-month | - | p.102 |
| Regulatory source | - | <226 | ppm | mouse | - | - | - | p.20 |
| Regulatory source | - | <226 | ppm | mouse | inhalation | 28 days | - | p.23 |
| Regulatory source | - | 300 | ppm | rat | - | - | - | p.93 |
| Regulatory source | - | =300 | ppm | rat | inhalation | 3-month | - | p.102 |
| Regulatory source | - | 700 | ppm | rat | - | chronic | - | p.28 |
| Regulatory source | dermal absorption | =0.1 | mg/kg bw/day | rat | dermal | 5 days | dermal absorption | p.99 |
| Regulatory source | dermal absorption | 150 | ppm | rat | dermal | 5 days | dermal absorption | p.99 |
| Regulatory source | repeated dose toxicity | 10 | ppm | rabbit | dermal | 12 months | repeated dose toxicity | p.28 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw | rat | oral | 5 day | repeated dose toxicity | p.73 |
| Regulatory source | repeated dose toxicity | 150 | ppm | rabbit | oral | 12 months | repeated dose toxicity | p.28 |
| Regulatory source | repeated dose toxicity | 150 | ppm | rat | oral | 28 days | repeated dose toxicity | p.28 |
| Regulatory source | repeated dose toxicity | 150 | ppm | - | - | chronic | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 150 | ppm | rat | oral | chronic | repeated dose toxicity | p.29 |
| Regulatory source | repeated dose toxicity | 150 | ppm | human | oral | chronic | repeated dose toxicity | p.100 |
| Regulatory source | repeated dose toxicity | 150 | ppm | - | oral | chronic | repeated dose toxicity | p.100 |
| Regulatory source | repeated dose toxicity | 300 | ppm | rat | oral | chronic | repeated dose toxicity | p.96 |
| Regulatory source | repeated dose toxicity | 300 | ppm | human | inhalation | chronic | repeated dose toxicity | p.101 |
| Regulatory source | repeated dose toxicity | 700 | ppm | rat | oral | subchronic | repeated dose toxicity | p.96 |
| Regulatory source | repeated dose toxicity | 960 | mg/kg | rat | inhalation | 14-day | repeated dose toxicity | p.17 |
| Regulatory source | repeated dose toxicity | 960 | mg/kg bw | rabbit | oral | 6 months | repeated dose toxicity | p.28 |
| Regulatory source | repeated dose toxicity | 1600 | mg/kg bw | rat | oral | 4 weeks | repeated dose toxicity | p.73 |
| Regulatory source | reproductive toxicity | 4 | - | rat | inhalation | 90-day | reproductive toxicity | p.60 |
| Regulatory source | reproductive toxicity | 80 | - | - | - | - | reproductive toxicity | p.80 |
| Regulatory source | reproductive toxicity | 150 | ppm | rat | inhalation | 3 days | reproductive toxicity | p.94 |
| Regulatory source | reproductive toxicity | 150 | ppm | rat | - | - | reproductive toxicity | p.97 |
| Regulatory source | reproductive toxicity | 160 | ppm | rat | - | developmental | reproductive toxicity | p.80 |
| Regulatory source | reproductive toxicity | 160 | ppm | - | - | developmental | reproductive toxicity | p.80 |
| Regulatory source | reproductive toxicity | 160 | ppm | rat | dermal | 90 days | reproductive toxicity | p.96 |
| Regulatory source | reproductive toxicity | 300 | ppm | rat | inhalation | developmental | reproductive toxicity | p.32 |
| Regulatory source | reproductive toxicity | 300 | ppm | - | - | - | reproductive toxicity | p.38 |
| Regulatory source | reproductive toxicity | 300 | ppm | rat | - | 274 days | reproductive toxicity | p.39 |
| Regulatory source | reproductive toxicity | 300 | ppm | rat | inhalation | 3 days | reproductive toxicity | p.94 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | CZ227117JE | UNII | - | - | - | chemical | - |