Regulatory Status
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Safety Data
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Expert Verdict
Pharmacologically active cardiovascular agent with risk of systemic toxicity; no cosmetic precedent and high regulatory and liability risk. Should be excluded from cosmetics unless formal SCCS/CIR safety dossier and regulatory pathway are established.
Frequently Asked Questions
Is Cyclovirobuxine safe in cosmetics?
Pharmacologically active cardiovascular agent with risk of systemic toxicity; no cosmetic precedent and high regulatory and liability risk. Should be excluded from cosmetics unless formal SCCS/CIR safety dossier and regulatory pathway are established. The EU classifies Cyclovirobuxine as "prohibited". Safety rating: POOR.
Is Cyclovirobuxine allowed in the EU?
Cyclovirobuxine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclovirobuxine do in cosmetics?
Cyclovirobuxine functions as: Pharmacologically active cardenolide-like alkaloid investigated as a cardiovascular drug. Not a standard cosmetic ingredient.. It is classified as a cosmetic ingredient in our database. CAS number: For Cyclovirobuxine D: 860‑79‑7. (Check whether your supplier’s ingredient is this exact alkaloid or a derivative.).
What is the Margin of Safety for Cyclovirobuxine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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