Is CYSTEINE HCL safe in cosmetics?
CYSTEINE HCL has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
CYSTEINE HCL
Also known as: cisteina, clorhidrato, Cystein chloride, CYSTEINE CHLORHYDRATE, Cysteine chlorohydrate, cysteine hydrochloride (+11 more)
CYSTEINE HCL (CAS 52-89-1) is a cosmetic cosmetic ingredient functioning as Antioxidant, Hair Conditioning, Hair Waving Or Straightening, Reducing. NOAEL 13 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 52-89-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Hair Conditioning, Hair Waving Or Straightening, Reducing
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2R)-2-amino-3-sulfanylpropanoic acid;hydrochloride
InChIKey
IFQSXNOEEPCSLW-DKWTVANSSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 32(Suppl. 4):41-64, 2013
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CYSTEINE HCL across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Filler
Flavouring and nutrient
Food preservative
Hair waving or straightening
Leavening agent
Reducing agent
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for CYSTEINE HCL.
Regulatory Flags
cosing-sourced
eu-permitted
hair-conditioning
antioxidant
needs-enrichment
fda_food_additive
Known Synonyms
cisteina, clorhidrato
Cystein chloride
CYSTEINE CHLORHYDRATE
Cysteine chlorohydrate
cysteine hydrochloride
Cysteine, chlorhydrate
Cysteinhydrochlorid
Cysteine, L-, monohydrochloride
EINECS 200-157-7
3-Mercaptoalanine hydrochloride
UNII-A9U1687S1S
Cysteine HCl (anhydrous)
Cysteine hydrochloride (anhydrous)
Cysteine monohydrochloride
L-Cysteine monohydrochloride
L-cysteinium chloride
Chemical Function
Antioxidant
Softener and conditioner
Reducing agent
Hair waving or straightening
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CYSTEINE HYDROCHLORIDE
ChEMBL ID
CHEMBL1200630
Max Phase
4
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
L-CYSTEINE MONOHYDROCHLORIDE
Food Category
flavoring
Frequently Asked Questions
Is CYSTEINE HCL allowed in the EU?
CYSTEINE HCL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CYSTEINE HCL do in cosmetics?
CYSTEINE HCL functions as: Antioxidant, Hair Conditioning, Hair Waving Or Straightening, Reducing. It is classified as a cosmetic ingredient in our database. CAS number: 52-89-1.
Is CYSTEINE HCL used outside cosmetics?
CYSTEINE HCL also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CYSTEINE HCL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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