Moderate Cosmetic Ingredient

Daphne Kiusiana Extract

INCI: DAPHNE KIUSIANA EXTRACT

CAS Number
Not assigned (whole‑plant or aerial‑part extract)
Function
Investigated as a wound-healing active enhancing keratinocyte migration via ERK/MMP-9; candidate skin-repair cosmetic active.
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes No explicit restriction; as a bioactive herbal extract, it must be shown safe under labeled use, and presence of potent diterpenes would be problematic if not controlled.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Belongs to a genus rich in daphnane-type diterpenes with known mitochondrial and systemic toxicity; before cosmetic use, fractionation to remove such compounds and a full toxicology package including genotoxicity and repeat-dose dermal studies are needed.

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Concern Level: High

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Daphne Kiusiana Extract safe in cosmetics?

Belongs to a genus rich in daphnane-type diterpenes with known mitochondrial and systemic toxicity; before cosmetic use, fractionation to remove such compounds and a full toxicology package including genotoxicity and repeat-dose dermal studies are needed. The EU classifies Daphne Kiusiana Extract as "prohibited". Safety rating: MODERATE.

Is Daphne Kiusiana Extract allowed in the EU?

Daphne Kiusiana Extract EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Daphne Kiusiana Extract do in cosmetics?

Daphne Kiusiana Extract functions as: Investigated as a wound-healing active enhancing keratinocyte migration via ERK/MMP-9; candidate skin-repair cosmetic active.. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (whole‑plant or aerial‑part extract).

What is the Margin of Safety for Daphne Kiusiana Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Daphne Kiusiana Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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