Regulatory Status
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Safety Data
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Expert Verdict
Coumarin-like structure presents class alerts for hepatotoxicity and sensitization at significant systemic exposure; potential photobiological activity and limited cosmetic-focused toxicology data warrant caution. Precautionary avoidance or minimal use recommended during pregnancy and lactation due to insufficient developmental toxicity data.
Regulatory Flags
Frequently Asked Questions
Is Daphnetin safe in cosmetics?
Coumarin-like structure presents class alerts for hepatotoxicity and sensitization at significant systemic exposure; potential photobiological activity and limited cosmetic-focused toxicology data warrant caution. Precautionary avoidance or minimal use recommended during pregnancy and lactation due to insufficient developmental toxicity data. The EU classifies Daphnetin as "prohibited". Safety rating: MODERATE.
Is Daphnetin allowed in the EU?
Daphnetin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Daphnetin do in cosmetics?
Daphnetin functions as: Antioxidant, skin-conditioning agent; polyphenolic coumarin from Daphne spp. with potential brightening and anti-inflammatory activity. It is classified as a cosmetic ingredient in our database. CAS number: 486-35-1.
What is the Margin of Safety for Daphnetin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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