Is Daphnetin safe in cosmetics?
Daphnetin has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Daphnetin
Also known as: 7,8-Dihydroxycoumarin, 2H-1-Benzopyran-2-one, 7,8-dihydroxy- (9CI), Coumarin, 7,8-dihydroxy-, 5-18-03-00211, BRN 0009372 (+5 more)
INCI: DAPHNETIN
Daphnetin (CAS 486-35-1) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin-conditioning agent; polyphenolic coumarin from Daphne spp. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 486-35-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Daphnetin is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant, skin-conditioning agent; polyphenolic coumarin from Daphne spp. with potential brightening and anti-inflammatory activity
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
7,8-dihydroxychromen-2-one
InChIKey
ATEFPOUAMCWAQS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not a specific FDA-monographed cosmetic ingredient; allowed under general safety provisions of FD&C Act when formulation is non-toxic and non-irritating. No specific restriction or monograph.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Daphnetin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Daphnetin.
Regulatory Flags
potential-allergen
Known Synonyms
7,8-Dihydroxycoumarin
2H-1-Benzopyran-2-one, 7,8-dihydroxy- (9CI)
Coumarin, 7,8-dihydroxy-
5-18-03-00211
BRN 0009372
7,8-Dihydroxy-2H-1-benzopyran-2-one
EINECS 207-632-8
NSC 633563
UNII-XC84571RD2
Daphnetol
Chemical Function
Softener and conditioner
Regulatory Lists
active_ingredient; Europe; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DAPHNETIN
ChEMBL ID
CHEMBL244948
Max Phase
-1
Frequently Asked Questions
Is Daphnetin allowed in the EU?
Daphnetin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Daphnetin do in cosmetics?
Daphnetin functions as: Antioxidant, skin-conditioning agent; polyphenolic coumarin from Daphne spp. with potential brightening and anti-inflammatory activity. It is classified as a cosmetic ingredient in our database. CAS number: 486-35-1.
Is Daphnetin used outside cosmetics?
Daphnetin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Daphnetin have different safety status in cosmetics vs industrial chemicals?
Daphnetin is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319).
Compliance Tools
Check Daphnetin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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