Moderate Cosmetic Ingredient

Daphniphyllum Macropodum Extract

INCI: DAPHNIPHYLLUM MACROPODUM EXTRACT

CAS Number
Not uniquely assigned (mixture; several Daphniphyllum alkaloids such as daphniphylline analogs are known pharmacologically)
Function
Skin-conditioning plant extract; occasionally positioned for soothing, anti-inflammatory, or antioxidant claims in niche products.
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes No explicit FDA cosmetic status; subject to general safety requirement (intended non-therapeutic use, no unreasonable risk). Not recognized as GRAS food plant; toxic botanical alkaloids are regulatory red flag if not sufficiently removed.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Plant contains complex alkaloids with CNS and cardiovascular activity; systemic toxicity risk from alkaloid carryover; batch-to-batch toxicological profile must be tightly controlled; caution in pregnancy, lactation, and compromised skin.

⚠️
Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Daphniphyllum Macropodum Extract safe in cosmetics?

Plant contains complex alkaloids with CNS and cardiovascular activity; systemic toxicity risk from alkaloid carryover; batch-to-batch toxicological profile must be tightly controlled; caution in pregnancy, lactation, and compromised skin. The EU classifies Daphniphyllum Macropodum Extract as "prohibited". Safety rating: MODERATE.

Is Daphniphyllum Macropodum Extract allowed in the EU?

Daphniphyllum Macropodum Extract EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Daphniphyllum Macropodum Extract do in cosmetics?

Daphniphyllum Macropodum Extract functions as: Skin-conditioning plant extract; occasionally positioned for soothing, anti-inflammatory, or antioxidant claims in niche products.. It is classified as a cosmetic ingredient in our database. CAS number: Not uniquely assigned (mixture; several Daphniphyllum alkaloids such as daphniphylline analogs are known pharmacologically).

What is the Margin of Safety for Daphniphyllum Macropodum Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Daphniphyllum Macropodum Extract compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Elaeocarpus Angustifolius Fruit/Seed Extract
Good
Maytenus Macrocarpa Bark Extract
Moderate
Green Coffee Bean Extract
Good
Hydroxygenistein
Moderate
Vitis Labrusca Fruit Extract
Good
Browse all 30,000+ ingredients →
📱

Is Daphniphyllum Macropodum Extract in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Daphniphyllum Macropodum Extract in your formulation.

Ingredient Decoder MoS Calculator