Decapeptide-19

INCI: DECAPEPTIDE-19

CAS Number
Not publicly specified; sequence Ala‑Cys‑Asp‑Gly‑Arg‑Thr‑Gln‑Ala‑Leu‑Cys described, but CAS not cited in open sources
Function
Anti-inflammatory and hair growth-promoting peptide; inhibits TNF-α activity and supports hair growth applications
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted as a cosmetic ingredient; explicit anti-inflammatory or TNF-α-modulating claims could be considered drug claims by FDA, requiring drug pathway if pursued

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Pharmacological mechanism via TNF-α inhibition and hair growth promotion raise borderline medical product concerns; should be avoided in products for compromised skin or users on immunomodulatory therapies unless medically supervised; claims must be carefully managed

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Concern Level: High

Frequently Asked Questions

Is Decapeptide-19 safe in cosmetics?

Pharmacological mechanism via TNF-α inhibition and hair growth promotion raise borderline medical product concerns; should be avoided in products for compromised skin or users on immunomodulatory therapies unless medically supervised; claims must be carefully managed The EU classifies Decapeptide-19 as "prohibited". Safety rating: MODERATE.

Is Decapeptide-19 allowed in the EU?

Decapeptide-19 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Decapeptide-19 do in cosmetics?

Decapeptide-19 functions as: Anti-inflammatory and hair growth-promoting peptide; inhibits TNF-α activity and supports hair growth applications. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly specified; sequence Ala‑Cys‑Asp‑Gly‑Arg‑Thr‑Gln‑Ala‑Leu‑Cys described, but CAS not cited in open sources.

What is the Margin of Safety for Decapeptide-19?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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