Moderate Cosmetic Ingredient

Decapeptide-20

INCI: DECAPEPTIDE-20

CAS Number
Not included in the referenced INCI page; CAS likely proprietary and not widely published
Function
Hair coloring, hair growth stimulation, and skin conditioning; CG-Promkine interacts with melanocyte-stimulating hormone receptors, activates tyrosinase, boosts melanin in hair, helps prevent grey hair and premature hair loss
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted as a cosmetic ingredient; hair growth and anti-hair loss claims may be considered drug claims by FDA; cosmetic-only positioning should focus on appearance, color, and cosmetic care

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Active modulation of melanin and hair cycle places it closer to borderline medicinal territory; avoid use in products intended for children or on compromised scalp; rigorous product-specific irritation and sensitization testing recommended

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Decapeptide-20 safe in cosmetics?

Active modulation of melanin and hair cycle places it closer to borderline medicinal territory; avoid use in products intended for children or on compromised scalp; rigorous product-specific irritation and sensitization testing recommended The EU classifies Decapeptide-20 as "permitted". Safety rating: MODERATE.

Is Decapeptide-20 allowed in the EU?

Decapeptide-20 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Decapeptide-20 do in cosmetics?

Decapeptide-20 functions as: Hair coloring, hair growth stimulation, and skin conditioning; CG-Promkine interacts with melanocyte-stimulating hormone receptors, activates tyrosinase, boosts melanin in hair, helps prevent grey hair and premature hair loss. It is classified as a cosmetic ingredient in our database. CAS number: Not included in the referenced INCI page; CAS likely proprietary and not widely published.

What is the Margin of Safety for Decapeptide-20?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Decapeptide-20 compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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