Deltamethrin NOAEL Studies

EFSA 6 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA	NOAEL	=1	mg/kg bw/day	Dog	oral: capsule	365 days	chronic/long term toxicity	EFSA PPR - 2009 - OutputID 764 - neurology - neurotoxicity - Potential developmental neurotoxicity of deltamethrin - doi:10.2903/j.efsa.2009.921
EFSA	ADI	=0.01	mg/kg bw/day	Consumers	-	-	ADI	EFSA PPR - 2009 - OutputID 764 - Consumers - Potential developmental neurotoxicity of deltamethrin - doi:10.2903/j.efsa.2009.921
EFSA	ADI	=0.01	mg/kg bw/day	Consumers	-	-	ADI	EFSA PPR - 2009 - OutputID 764 - Consumers - Potential developmental neurotoxicity of deltamethrin - doi:10.2903/j.efsa.2009.921
EFSA	ARfD	=0.01	mg/kg bw	Consumers	-	-	ARfD	EFSA PPR - 2009 - OutputID 764 - Consumers - Potential developmental neurotoxicity of deltamethrin - doi:10.2903/j.efsa.2009.921
EFSA	ARfD	=0.01	mg/kg bw	Consumers	-	-	ARfD	EFSA PPR - 2009 - OutputID 764 - Consumers - Potential developmental neurotoxicity of deltamethrin - doi:10.2903/j.efsa.2009.921
EFSA	NOAEL	=1	mg/kg bw/day	Dog	oral	subchronic; 13 weeks	subchronic	LONG_REF=EFSA PPR (2009). Potential developmental neurotoxicity of deltamethrin. doi:10.2903/j.efsa.2009.921.; TITLE=Potential developmental neurotoxicity of deltamethrin; AUTHOR=EFSA PPR; DOI=doi:10.2903/j.efsa.2009.921; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=neurology; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15623844:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_94c0d880d47ad8b4397070ea929e9c97

IARC Monographs 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
IARC Monographs	IARC carcinogenicity classification	3	IARC group	-	-	1990	IARC Monographs	{"additional_info":"volume_publication_year=1991","evaluation_year":1990,"source_table":"iarc_classifications","volume":"53"}

WHO/JECFA 5 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
WHO/JECFA	NOEL	=1	mg/kg bw/day	Dog	oral	2-year	Chronic toxicity	document_id=ehc_ehc_ehc97; title=Deltamethrin (EHC 97, 1990); path=mirror/documents/ehc/ehc/ehc97.htm; row_hash=9678cd38b3aaf961; raw_unit=mg/kg body weight per day; context=In a 2-year feeding study on dogs, 1 mg/kg body weight per day was the no-observed-effect level (highest level tested).
WHO/JECFA	NOEL	=50	mg/kg diet	-	oral	-	Toxicology study	document_id=ehc_ehc_ehc97; title=Deltamethrin (EHC 97, 1990); path=mirror/documents/ehc/ehc/ehc97.htm; row_hash=1d8e9d24361aa64c; raw_unit=mg/kg diet; context=The no-observed-effect level for systemic toxicity was 50 mg/kg diet.
WHO/JECFA	NOEL	=1	mg/kg bw	-	-	-	Toxicology study	document_id=ehc_ehc_ehc97; title=Deltamethrin (EHC 97, 1990); path=mirror/documents/ehc/ehc/ehc97.htm; row_hash=ccf004b45d5b64a6; raw_unit=mg/kg body weight; context=The no-observed-effect level was 1 mg/kg body weight (Hunter et al., 1977).
WHO/JECFA	NOEL	=100	mg/kg diet	-	oral	-	Toxicology study	document_id=ehc_ehc_ehc97; title=Deltamethrin (EHC 97, 1990); path=mirror/documents/ehc/ehc/ehc97.htm; row_hash=154fb618119df6bc; raw_unit=mg/kg diet; context=The no-observed-effect level was 100 mg/kg diet (Goldenthal et al., 1980a).
WHO/JECFA	ADI	<=0.01	mg/kg	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afcdae4b0d99f5a87d282; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/70; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=WHO JECFA ADI:15715442:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a42a32b70a975f340185676eacfe66c0

NTP ICE acute dermal 5 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute dermal	EPA classification	3	unitless	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1978; Record_ID=acute_dermal_146; Data_Type=In Vivo; Formulation_ID=MIX142; Formulation_Name=Decis 1.0 Gel; Percent_Active_Ingredient=11.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute dermal	EPA classification	4	unitless	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1979; Record_ID=acute_dermal_187; Data_Type=In Vivo; Formulation_ID=MIX179; Formulation_Name=DP210 Professional Insecticide; Percent_Active_Ingredient=0.02; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute dermal	GHS classification	5	unitless	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1975; Record_ID=acute_dermal_444; Data_Type=In Vivo; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=0.75; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute dermal	LD50	>2000	mg/kg	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1974; Record_ID=acute_dermal_146; Data_Type=In Vivo; Formulation_ID=MIX142; Formulation_Name=Decis 1.0 Gel; Percent_Active_Ingredient=11.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute dermal	LD50	>5000	mg/kg	Rat	Dermal	-	In Vivo; Rat Acute Dermal Toxicity	sheet=Data; excel_row=1976; Record_ID=acute_dermal_187; Data_Type=In Vivo; Formulation_ID=MIX179; Formulation_Name=DP210 Professional Insecticide; Percent_Active_Ingredient=0.02; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381

NTP ICE acute inhalation 7 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute inhalation	EPA Classification	3	unitless	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=4339; Record_ID=acute_inhalation_389; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX468; Formulation_Name=Storicide II Grain, Bin and Warehouse Insecticide; Percent_Active_Ingredient=3.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute inhalation	GHS Classification	4	unitless	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=4341; Record_ID=acute_inhalation_363; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=0.75; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute inhalation	LC50	0.785	mg/L	-	Inhalation	Duration=2 hr	In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=4337; Record_ID=acute_inhalation_2841; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8020381; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.785; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute inhalation	LC50	>2.04	mg/L	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=4338; Record_ID=acute_inhalation_363; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=0.75; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.04; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute inhalation	LC50	0.7	mg/L	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=4340; Record_ID=acute_inhalation_87; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX142; Formulation_Name=Decis 1.0 Gel; Percent_Active_Ingredient=11.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.7; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute inhalation	LC50	4.35	mg/L	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=4342; Record_ID=acute_inhalation_112; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX179; Formulation_Name=DP210 Professional Insecticide; Percent_Active_Ingredient=0.02; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.35; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE acute inhalation	LC50	range0.53	mg/L	-	Inhalation	-	In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=4348; Record_ID=acute_inhalation_389; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX468; Formulation_Name=Storicide II Grain, Bin and Warehouse Insecticide; Percent_Active_Ingredient=3.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>0.53 and <2.58; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381

NTP ICE acute oral 15 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute oral	EPA classification	=2	Unitless	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12451; row=13179; data_type=In Vivo; mixture=Mixture; formulation_id=MIX142; formulation_name=Decis 1.0 Gel; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=11.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	EPA classification	=2	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12974; row=13182; data_type=In Vivo; mixture=Mixture; formulation_id=MIX658; formulation_name=Storicide II Grain, Bin to Warehouse Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=3.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	EPA classification	=3	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12981; row=13184; data_type=In Vivo; mixture=Mixture; formulation_id=MIX438; formulation_name=Shooter Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=0.75; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	EPA classification	=4	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12527; row=13177; data_type=In Vivo; mixture=Mixture; formulation_id=MIX179; formulation_name=DP210 Professional Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=0.02; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	GHS classification	=3	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12974; row=13164; data_type=In Vivo; mixture=Mixture; formulation_id=MIX658; formulation_name=Storicide II Grain, Bin to Warehouse Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=3.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	GHS classification	=3	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12455; row=13183; data_type=In Vivo; mixture=Mixture; formulation_id=MIX142; formulation_name=Decis 1.0 Gel; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=11.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	GHS classification	=4	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12981; row=13168; data_type=In Vivo; mixture=Mixture; formulation_id=MIX438; formulation_name=Shooter Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=0.75; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	GHS classification	=4	Unitless	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12451; row=13186; data_type=In Vivo; mixture=Mixture; formulation_id=MIX142; formulation_name=Decis 1.0 Gel; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=11.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	GHS classification	=5	Unitless	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12527; row=13165; data_type=In Vivo; mixture=Mixture; formulation_id=MIX179; formulation_name=DP210 Professional Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=0.02; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=150	mg/kg bw	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12974; row=13175; data_type=In Vivo; mixture=Mixture; formulation_id=MIX658; formulation_name=Storicide II Grain, Bin to Warehouse Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=3.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=196	mg/kg bw	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12455; row=13171; data_type=In Vivo; mixture=Mixture; formulation_id=MIX142; formulation_name=Decis 1.0 Gel; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=11.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=249	mg/kg bw	Rat (Male/Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12453; row=13170; data_type=In Vivo; mixture=Mixture; formulation_id=MIX142; formulation_name=Decis 1.0 Gel; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=11.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=322	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12451; row=13169; data_type=In Vivo; mixture=Mixture; formulation_id=MIX142; formulation_name=Decis 1.0 Gel; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=11.7; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	=1750	mg/kg bw	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12981; row=13176; data_type=In Vivo; mixture=Mixture; formulation_id=MIX438; formulation_name=Shooter Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=0.75; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	>5000	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12529; row=13172; data_type=In Vivo; mixture=Mixture; formulation_id=MIX179; formulation_name=DP210 Professional Insecticide; chemical_name=Deltamethrin; preferred_name=Deltamethrin; percent_active_ingredient=0.02; dtxsid=DTXSID8020381; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8020381; source_file=acute_oral.xlsx

NTP ICE adme parameters 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE adme parameters	Clint	7	uL/min/10^6 cells	Rat	-	-	Measured; httk, Rat Hepatic Intrinsic Clearance	sheet=Data; excel_row=3088; Record_ID=adme_parameters_1350; Data_Type=Measured; DTXSID=DTXSID8020381; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=7.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE adme parameters	Fu	0.049	fraction	Rat	-	-	Measured; httk, Rat Plasma Fraction Unbound	sheet=Data; excel_row=3087; Record_ID=adme_parameters_1350; Data_Type=Measured; DTXSID=DTXSID8020381; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.049; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE adme parameters	Fu	0.01	fraction	Human	-	-	Measured; httk, Human Plasma Fraction Unbound	sheet=Data; excel_row=3089; Record_ID=adme_parameters_1350; Data_Type=Measured; DTXSID=DTXSID8020381; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.01; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, ECVAM; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381

NTP ICE cancer 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE cancer	IARC group	3	unitless	-	-	-	WOE; IARC Carcinogenicity	sheet=Data; excel_row=8657; Record_ID=cancer_1985; Data_Type=WOE; Formulation_Name=Deltamethrin; Mixture=Chemical; DTXSID=DTXSID8020381; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/71; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381

NTP ICE endocrine 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE endocrine	IC25	5840	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13055; Record_ID=endocrine_invitro_3377; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020381; Assay=AR Transactivation-Antagonist; Endpoint=IC25; Reported_Response=5840; Reported_Response_Unit=IC25 (nM); Response=5840; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381
NTP ICE endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=7494; RecordID=ARPathway2016_1284; DatasetName=ARPathway2016; DTXSID=DTXSID8020381; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381
NTP ICE endocrine	NOEL	2.5	mg/kg bw/day	Rat	Oral	Treatment_Duration=7 days; Age_at_First_Dose=PND 42; Age_Ovariectomized_or_Castrated=PND 28; Time_Elapsed_Between_Surgery_and_Treatment=14 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=<24 hours; Number_of_Doses_Tested=6	In Vivo; Hershberger-Antagonist	sheet=Data_invivo; excel_row=2217; Record_ID=endocrine_invivo_955; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8020381; Assay=Hershberger-Antagonist; Endpoint=NOEL; Response=2.5; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Male (castrated); Route=Oral; Reference_Hormone=Flutamide; Reference_Hormone_Dose=20; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 598; Reference=Birkhoj et al. 2004; 15519604; 10.1016/j.taap.2004.04.016|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381
NTP ICE endocrine	RIC20	13.2	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13344; Record_ID=endocrine_invitro_3359; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8020381; Assay=AR Transactivation-Antagonist; Endpoint=RIC20; Reported_Response=13.2; Reported_Response_Unit=RIC20 (nM); Response=13.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381

NTP ICE eye irritation 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE eye irritation	EPA Classification	1	unitless	Rabbit	Ocular	-	In Vivo; Draize Eye Irritation/Corrosion Test	sheet=Data; excel_row=2286; Record_ID=eye_irritation_1078; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID905; Formulation_Name=Storicide II Grain, Bin and Warehouse Insecticide; Percent_Active_Ingredient=3.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE eye irritation	EPA Classification	3	unitless	Rabbit	Ocular	-	In Vivo; Draize Eye Irritation/Corrosion Test	sheet=Data; excel_row=2288; Record_ID=eye_irritation_1024; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID874; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=0.75; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE eye irritation	EPA Classification	4	unitless	Rabbit	Ocular	-	In Vivo; Draize Eye Irritation/Corrosion Test	sheet=Data; excel_row=2291; Record_ID=eye_irritation_515; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID332; Formulation_Name=DP210 Professional Insecticide; Percent_Active_Ingredient=0.02; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381

NTP ICE skin irritation 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE skin irritation	EPA classification	4	unitless	Rabbit	Dermal	-	In Vivo; Draize Skin Irritation/Corrosion Test	sheet=Data_invivo; excel_row=1519; Record_ID=skin_irritation_invivo_403; Data_Type=In Vivo; Formulation_ID=MIX179; Formulation_Name=DP210 Professional Insecticide; Percent_Active_Ingredient=0.02; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE skin irritation	EPA classification	2	unitless	Rabbit	Dermal	-	In Vivo; Draize Skin Irritation/Corrosion Test	sheet=Data_invivo; excel_row=1520; Record_ID=skin_irritation_invivo_1297; Data_Type=In Vivo; Formulation_ID=MIX142; Formulation_Name=Decis 1.0 Gel; Percent_Active_Ingredient=11.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male/Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381
NTP ICE skin irritation	EPA classification	3	unitless	Rabbit	Dermal	-	In Vivo; Draize Skin Irritation/Corrosion Test	sheet=Data_invivo; excel_row=1522; Record_ID=skin_irritation_invivo_845; Data_Type=In Vivo; Formulation_ID=MIX438; Formulation_Name=Shooter Insecticide; Percent_Active_Ingredient=0.75; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8020381

NTP ICE skin sensitization 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE skin sensitization	GHS Classification	1	unitless	Guinea pig	Dermal	-	In Vivo; SkinSensitization6pack; Guinea Pig Maximization/Buehler	sheet=Data_invivo; excel_row=1318; Record_ID=skin_sensitization_invivo_377; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX468; Formulation_Name=Storicide II Grain, Bin and Warehouse Insecticide; Percent_Active_Ingredient=3.7; Mixture=Mixture; DTXSID=DTXSID8020381; Assay=Guinea Pig Maximization/Buehler; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Guinea pig; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020381

EPA ToxRefDB v3 26 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EPA ToxRefDB v3	LEL	=2.5	mg/kg bw/day	rat (sprague dawley; Sprague Dawley (CD))	oral	0 week to 13 week	SUB	study_id=3440; toxval_study_source_id=studyid3440_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-clinical signs-hypersensitivity; dose_level=3; study_year=1977; study_citation=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.): Huntingdon Research Centre, RSL254/76938/A3, Mar. 21, 1977: EPA Acc. #:. 070736, TAB C-29; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=7	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	6 GD to 15 GD	DEV	study_id=3442; toxval_study_source_id=studyid3442_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-body surface staining|in life observation-body weight-body weight|in life observation-clinical signs-salivation|in life observation-clinical signs-convulsions|in life observation-mortality-mortality|in life observation-body weight-body weight gain|in life observation-clinical signs-anogenital staining|in life observation-clinical signs-hypersensitivity; dose_level=3; study_year=1990; study_citation=Schardein, J. (1990) Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120. Unpublished study prepared by International Research and Development Corp. 140 p.; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	>11	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	6 GD to 15 GD	DEV	study_id=3442; toxval_study_source_id=studyid3442_Fetal_Fetal_MF_NA; dose_level=4; study_year=1990; study_citation=Schardein, J. (1990) Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120. Unpublished study prepared by International Research and Development Corp. 140 p.; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=32	mg/kg bw/day	rabbit (new zealand white; New Zealand White)	oral	6 GD to 28 GD	DEV	study_id=3443; toxval_study_source_id=studyid3443_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=3; study_year=2001; study_citation=Richard, J. (2001) Deltamethrin: Prenatal Developmental Toxicity Study by Oral Route (Gavage) in Rabbits: Lab Project Number: 21559 RSL. Unpublished study prepared by CIT. 309 p. {OPPTS 870.3700}; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=23.5	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-ataxia|in life observation-food consumption-food consumption|in life observation-mortality-mortality|in life observation-clinical signs-hypersensitivity|in life observation-body weight-body weight gain; dose_level=4; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=21.2	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F0_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-clinical signs-external lesion(s)|in life observation-clinical signs-alopecia|in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=4; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=27.2	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F1_F_systemic; toxval_effect_list=pathology gross-brain-[other]|in life observation-clinical signs-salivation|pathology gross-adrenal gland-enlarged|in life observation-clinical signs-impaired righting reflex|in life observation-food consumption-food consumption|in life observation-clinical signs-body surface staining|in life observation-clinical signs-excessive or spontaneous vocalization|in life observation-mortality-mortality|in life observation-body weight-body weight|in life observation-clinical signs-discolored digesta|in life observation-body weight-body weight gain|in life observation-clinical signs-splayed hindlimbs|pathology gross-skin-lesion(s) (nos)|in life observation-clinical signs-hyperactivity|in life observation-clinical signs-ataxia; dose_level=4; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=24.9	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F1_M_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-clinical signs-impaired righting reflex|in life observation-clinical signs-splayed hindlimbs|in life observation-clinical signs-ataxia|pathology gross-brain-[other]|in life observation-food consumption-food consumption|in life observation-clinical signs-excessive or spontaneous vocalization|in life observation-clinical signs-salivation|in life observation-body weight-body weight|pathology gross-stomach-erosion|pathology gross-skin-lesion(s) (nos)|pathology gross-adrenal gland-enlarged|in life observation-clinical signs-discolored digesta|in life observation-clinical signs-body surface staining|in life observation-body weight-body weight gain|in life observation-clinical signs-hyperactivity; dose_level=4; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	>1.134	mg/kg bw/day	dog (beagle)	oral	0 month to 24 month	CHR	study_id=3447; toxval_study_source_id=studyid3447_Adult_F0_F_NA; dose_level=3; study_year=1980; study_citation=Goldenthal, E.I.; Arceo, R.J.; Brewer, L. (1980) 2-year Chronic Dog Feeding Study: ?RU 22974 (Decametrine)|: IRDC-406-004/A1. (Unpublished study received Mar 25, 1982 under 2E2663; prepared by International Research and Development Corp., submitted by Ame; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=10	mg/kg bw/day	dog (beagle; beagle)	oral	0 week to 52 week	CHR	study_id=3448; toxval_study_source_id=studyid3448_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-chewing of extremities|in life observation-clinical signs-abnormal gait|in life observation-clinical signs-unwilling to stand/walk|in life observation-clinical signs-tremors|in life observation-clinical signs-watery stools; dose_level=2; study_year=1993; study_citation=Ryle, P.; Path, R.; Path, M. et al. (1993) Deltamethrin: Toxicity to Dogs by Repeated Oral Administration for 52 Weeks: Lab Project Number: RSL 816/920929. Unpublished study prepared by Huntingdon Research Centre, Ltd. 236 p.; dsstox_substance_id=DTXSID8020381; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	>395.1	mg/kg bw/day	mouse (cd1; Crl:CD-1(ICR)BR)	oral	0 day to 97 week	CHR	study_id=3449; toxval_study_source_id=studyid3449_Adult_F0_F_NA; dose_level=4; study_year=1995; study_citation=Richard, J. (1995) Deltamethrin: 97-Week Carcinogenicity Study by Oral Route (Dietary Admixture) in Mice. Lab Project Number: 7347TCS: A70820: 7347TCS/DELTAMETHRIN. Unpublished study prepared by Centre International de. Toxicologie (C.I.T.). 2041 p.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	>15	mg/kg bw/day	mouse (cd1; Crl:CD)	oral	0 month to 24 month	CHR	study_id=3451; toxval_study_source_id=studyid3451_Adult_F0_F_NA; dose_level=4; study_year=1980; study_citation=Goldenthal, E.I.; Arceo, R.J.; Gunderson, G.; et al. (1980) Two- year Oral Toxicity and Carcinogenicity Study in Mice: Ref. IRDC 406-001 A/4. (Unpublished study received Mar 25, 1982 under 2E2663; prepared by International Research and Development Corp.,; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	>47.1	mg/kg bw/day	rat (sprague dawley; Crl:CD(SD)BR)	oral	0 day to 104 week	CHR	study_id=3452; toxval_study_source_id=studyid3452_Adult_F0_F_NA; dose_level=4; study_year=1995; study_citation=Ryle, P. (1995) Deltamethrin: Potential Tumorigenic and Toxic Effects in Prolonged Dietary Administration to Rats: Lab Project Number: RSL 814: A70821: RSL 814/932275. Unpublished study prepared by Huntingdon Research Centre, Ltd. 3012 p.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=16.1	mg/kg bw/day	rat (Wistar rat; Crl:WI(Glx/BRL/Han) IGS BR)	oral	6 GD (gestation day) to 1 Generation	DNT	study_id=826342; toxval_study_source_id=studyid826342_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=3; study_year=2006; study_citation=Gilmore, R.G., L.P. Sheets, and H.E. Hoss (2006) A developmental neurotoxicity screening study with technical grade deltamethrin in Wistar rats. Bayer CropScience LP Toxicology, Stilwell, KS. Study number 04-D72-WO, April 3, 2006. MRID 46814301. Unpublished .; dsstox_substance_id=DTXSID8020381; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LEL	=16.1	mg/kg bw/day	rat (Wistar rat; Crl:WI(Glx/BRL/Han) IGS BR)	oral	6 GD (gestation day) to 1 Generation	DNT	study_id=826342; toxval_study_source_id=studyid826342_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=3; study_year=2006; study_citation=Gilmore, R.G., L.P. Sheets, and H.E. Hoss (2006) A developmental neurotoxicity screening study with technical grade deltamethrin in Wistar rats. Bayer CropScience LP Toxicology, Stilwell, KS. Study number 04-D72-WO, April 3, 2006. MRID 46814301. Unpublished .; dsstox_substance_id=DTXSID8020381; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LOAEL	>10	mg/kg bw/day	rat (sprague dawley; Sprague Dawley (CD))	oral	0 week to 13 week	SUB	study_id=3440; toxval_study_source_id=studyid3440_Adult_F0_F_NA; dose_level=4; study_year=1977; study_citation=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.): Huntingdon Research Centre, RSL254/76938/A3, Mar. 21, 1977: EPA Acc. #:. 070736, TAB C-29; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	LOAEL	=50	mg/kg bw/day	dog (beagle; beagle)	oral	0 week to 52 week	CHR	study_id=3448; toxval_study_source_id=studyid3448_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-abnormal gait|in life observation-clinical signs-unwilling to stand/walk|in life observation-clinical signs-tremors; dose_level=3; study_year=1993; study_citation=Ryle, P.; Path, R.; Path, M. et al. (1993) Deltamethrin: Toxicity to Dogs by Repeated Oral Administration for 52 Weeks: Lab Project Number: RSL 816/920929. Unpublished study prepared by Huntingdon Research Centre, Ltd. 236 p.; dsstox_substance_id=DTXSID8020381; admin_method=Capsule; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=1	mg/kg bw/day	rat (sprague dawley; Sprague Dawley (CD))	oral	0 week to 13 week	SUB	study_id=3440; toxval_study_source_id=studyid3440_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-clinical signs-hypersensitivity; dose_level=2; study_year=1977; study_citation=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.): Huntingdon Research Centre, RSL254/76938/A3, Mar. 21, 1977: EPA Acc. #:. 070736, TAB C-29; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=3.3	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	6 GD to 15 GD	DEV	study_id=3442; toxval_study_source_id=studyid3442_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-hypersensitivity|in life observation-clinical signs-anogenital staining|in life observation-clinical signs-convulsions|in life observation-clinical signs-body surface staining|in life observation-body weight-body weight|in life observation-clinical signs-salivation|in life observation-mortality-mortality|in life observation-body weight-body weight gain; dose_level=2; study_year=1990; study_citation=Schardein, J. (1990) Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120. Unpublished study prepared by International Research and Development Corp. 140 p.; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=10	mg/kg bw/day	rabbit (new zealand white; New Zealand White)	oral	6 GD to 28 GD	DEV	study_id=3443; toxval_study_source_id=studyid3443_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight; dose_level=2; study_year=2001; study_citation=Richard, J. (2001) Deltamethrin: Prenatal Developmental Toxicity Study by Oral Route (Gavage) in Rabbits: Lab Project Number: 21559 RSL. Unpublished study prepared by CIT. 309 p. {OPPTS 870.3700}; dsstox_substance_id=DTXSID8020381; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=6.1	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-clinical signs-hypersensitivity|in life observation-mortality-mortality|in life observation-food consumption-food consumption|in life observation-body weight-body weight|in life observation-clinical signs-ataxia; dose_level=3; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=5.4	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-clinical signs-external lesion(s)|in life observation-food consumption-food consumption|in life observation-clinical signs-alopecia|in life observation-body weight-body weight; dose_level=3; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=6.7	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F1_F_systemic; toxval_effect_list=in life observation-clinical signs-body surface staining|in life observation-clinical signs-excessive or spontaneous vocalization|in life observation-mortality-mortality|in life observation-clinical signs-discolored digesta|in life observation-body weight-body weight|pathology gross-brain-[other]|in life observation-clinical signs-salivation|in life observation-food consumption-food consumption|in life observation-clinical signs-impaired righting reflex|pathology gross-adrenal gland-enlarged|in life observation-clinical signs-ataxia|in life observation-clinical signs-hyperactivity|pathology gross-skin-lesion(s) (nos)|in life observation-clinical signs-splayed hindlimbs|in life observation-body weight-body weight gain; dose_level=3; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=5.8	mg/kg bw/day	rat (sprague dawley; Sprague Dawley)	oral	82 days (premating) to 2 generation	MGR	study_id=3446; toxval_study_source_id=studyid3446_Adult_F1_M_systemic; toxval_effect_list=pathology gross-brain-[other]|in life observation-clinical signs-salivation|in life observation-clinical signs-splayed hindlimbs|in life observation-clinical signs-ataxia|in life observation-mortality-mortality|in life observation-clinical signs-impaired righting reflex|in life observation-clinical signs-excessive or spontaneous vocalization|in life observation-food consumption-food consumption|in life observation-clinical signs-discolored digesta|in life observation-clinical signs-body surface staining|in life observation-clinical signs-hyperactivity|in life observation-body weight-body weight gain|pathology gross-skin-lesion(s) (nos)|pathology gross-stomach-erosion|in life observation-body weight-body weight|pathology gross-adrenal gland-enlarged; dose_level=3; study_year=1992; study_citation=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; dsstox_substance_id=DTXSID8020381; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=6.78	mg/kg bw/day	rat (Wistar rat; Crl:WI(Glx/BRL/Han) IGS BR)	oral	6 GD (gestation day) to 1 Generation	DNT	study_id=826342; toxval_study_source_id=studyid826342_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=2; study_year=2006; study_citation=Gilmore, R.G., L.P. Sheets, and H.E. Hoss (2006) A developmental neurotoxicity screening study with technical grade deltamethrin in Wistar rats. Bayer CropScience LP Toxicology, Stilwell, KS. Study number 04-D72-WO, April 3, 2006. MRID 46814301. Unpublished .; dsstox_substance_id=DTXSID8020381; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3	NEL	=6.78	mg/kg bw/day	rat (Wistar rat; Crl:WI(Glx/BRL/Han) IGS BR)	oral	6 GD (gestation day) to 1 Generation	DNT	study_id=826342; toxval_study_source_id=studyid826342_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-food consumption-food consumption|in life observation-body weight-body weight gain; dose_level=2; study_year=2006; study_citation=Gilmore, R.G., L.P. Sheets, and H.E. Hoss (2006) A developmental neurotoxicity screening study with technical grade deltamethrin in Wistar rats. Bayer CropScience LP Toxicology, Stilwell, KS. Study number 04-D72-WO, April 3, 2006. MRID 46814301. Unpublished .; dsstox_substance_id=DTXSID8020381; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5

ToxValDB AU DWG 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB AU DWG	NOEL	=1	mg/kg bw/day	Dog	oral	chronic; 2 years	chronic	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c82db5e4b02565fc7d237c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nhmrc.gov.au; SUBSOURCE_URL=https://www.nhmrc.gov.au/sites/default/files/documents/attachments/publications/Australian_Drinking_Water_Guidelines_ADWG_V3-8_Sep2022.pdf; TOXICOLOGICAL_EFFECT=clinical effects, including dilation of the pupils, decreased weight gain, vomiting and diarrhoea.; STUDY_GROUP=AU DWG:15951600:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1d61ba05e4ad3395035a82ac17a1d36c

ToxValDB Cal OEHHA 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB Cal OEHHA	NOEL	=0.1	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Goldenthal, 1980; AUTHOR=Goldenthal; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669e7d1ce4b0a7c65d1a9757; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/chemicals; SUBSOURCE_URL=https://oehha.ca.gov/media/downloads/crnr/atrazinedeltramethrin100407.pdf; TOXICOLOGICAL_EFFECT=degeneration of sciatic, tibial, and plantar nerves; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=Cal OEHHA:15449274:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57e135668cddb4e11971f2a35b6121ff
ToxValDB Cal OEHHA	RfD	=0.0001	mg/kg bw/day	Human	oral	chronic	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669e7d1ce4b0a7c65d1a9761; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/chemicals; SUBSOURCE_URL=https://oehha.ca.gov/chemicals/deltamethrin; YEAR=2023; ORIGINAL_YEAR=2023; STUDY_GROUP=Cal OEHHA:15449237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c444bcb0f2c697aa6831a6e94ea0bc12

ToxValDB ECOTOX 96 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB ECOTOX	LOEL	=0.1	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Fresenius Environ. Bull.5(7/8): 380-385 Shepelskaya,N.R. The Effect of Pesticides Decis, Polyram, 2,4-D Complex on the Reproductive System. Communication 1. Reproductive Toxicity of Decis 1996; TITLE=The Effect of Pesticides Decis, Polyram, 2,4-D Complex on the Reproductive System. Communication 1. Reproductive Toxicity of Decis; AUTHOR=Shepelskaya,N.R.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=93916; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Reproduction: Pre-implantation loss; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594145_15594146_15595496:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f9725068a3468da94e5912ca9da1b81d
ToxValDB ECOTOX	LOEL	=30	mg/kg bw/day	Rat	injection	acute; 0.0208 days	acute	LONG_REF=Neurotoxicol. Teratol.17(4): 489-495 Crofton,K.M., L.S. Kehn, and M.E. Gilbert Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat 1995; TITLE=Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat; AUTHOR=Crofton,K.M., L.S. Kehn, and M.E. Gilbert; DOI=10.1016/0892-0362(95)00008-f; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=48434; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Movements, number of; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594414_15600693_15602086_15605853:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ae86105a19f270d3996c82f38953618e
ToxValDB ECOTOX	LOEL	=0.6144	mg/kg bw/day	Rat	oral	subchronic; 60 days	subchronic	LONG_REF=Chem.-Biol. Interact.206(2): 302-308 Liang,Y.J., H.P. Wang, D.X. Long, W. Li, and Y.J. Wu A Metabonomic Investigation of the Effects of 60 Days Exposure of Rats to Two Types of Pyrethroid Insecticides 2013; TITLE=A Metabonomic Investigation of the Effects of 60 Days Exposure of Rats to Two Types of Pyrethroid Insecticides; AUTHOR=Liang,Y.J., H.P. Wang, D.X. Long, W. Li, and Y.J. Wu; DOI=10.1016/j.cbi.2013.10.002; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=168405; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Biochemistry: Lactate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594480_15594481:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9de8a159f0a34751d0488f74c4652dd1
ToxValDB ECOTOX	LOEL	=15	mg/kg bw/day	Rat	oral	short-term; 7 days	short-term	LONG_REF=Environ. Toxicol. Pharmacol.7(3): 169-178 Dayal,M., D. Parmar, A. Dhawan, U.N. Dwivedi, J. Doehmer, and P.K. Seth Induction of Rat Brain and Liver Cytochrome P450 1A1/1A2 and 2B1/2B2 Isoenzymes by Deltamethrin 1999; TITLE=Induction of Rat Brain and Liver Cytochrome P450 1A1/1A2 and 2B1/2B2 Isoenzymes by Deltamethrin; AUTHOR=Dayal,M., D. Parmar, A. Dhawan, U.N. Dwivedi, J. Doehmer, and P.K. Seth; DOI=10.1016/s1382-6689(99)00011-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109508; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594654_15594655_15600555_15606215_15606216:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1c97f07a46819fbddeb08cbe26d17af3
ToxValDB ECOTOX	LOEL	=3	mg/kg bw/day	Rat	oral	acute; 0.125 days	acute	LONG_REF=Neurotoxicology11(1): 73-86 Gilbert,M.E., S.K. Acheson, C.M. Mack, and K.M. Crofton An Examination of the Proconvulsant Actions of Pyrethroid Insecticides Using Pentylenetetrazol and Amygdala Kindling Seizure Models 1990; TITLE=An Examination of the Proconvulsant Actions of Pyrethroid Insecticides Using Pentylenetetrazol and Amygdala Kindling Seizure Models; AUTHOR=Gilbert,M.E., S.K. Acheson, C.M. Mack, and K.M. Crofton; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109626; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594923_15594924:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5af99970bfee0257403aaed7387ff91d
ToxValDB ECOTOX	LOEL	=60	mg/kg bw/day	Rat	injection	acute; 0.0417 days	acute	LONG_REF=Toxicol. Appl. Pharmacol.217(1): 25-34 Mubarak Hossain,M., T. Suzuki, N. Sato, I. Sato, T. Takewaki, K. Suzuki, E. Tachikawa, and H. Kobayashi Differential Effects of Pyrethroid Insecticides on Extracellular Dopamine in the Striatum of Freely Moving Rats 2006; TITLE=Differential Effects of Pyrethroid Insecticides on Extracellular Dopamine in the Striatum of Freely Moving Rats; AUTHOR=Mubarak Hossain,M., T. Suzuki, N. Sato, I. Sato, T. Takewaki, K. Suzuki, E. Tachikawa, and H. Kobayashi; DOI=10.1016/j.taap.2006.07.011; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109849; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Physiology: Dopamine uptake; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595231_15595232:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9e8bcf94a06b08643710dbeaf9f3f22b
ToxValDB ECOTOX	LOEL	=25	mg/kg bw/day	Rat	injection	acute; 0.2083 days	acute	LONG_REF=J. Pharmacol. Exp. Ther.316(1): 136-143 Imamura,L., M. Yasuda, K. Kuramitsu, D. Hara, A. Tabuchi, and M. Tsuda Deltamethrin, a Pyrethroid Insecticide, is a Potent Inducer for the Activity-Dependent Gene Expression of Brain-Derived Neurotrophic Factor in Neurons 2006; TITLE=Deltamethrin, a Pyrethroid Insecticide, is a Potent Inducer for the Activity-Dependent Gene Expression of Brain-Derived Neurotrophic Factor in Neurons; AUTHOR=Imamura,L., M. Yasuda, K. Kuramitsu, D. Hara, A. Tabuchi, and M. Tsuda; DOI=10.1124/jpet.105.092478; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109686; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Genetics: RNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX:15595245:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=82e92fb9ba337f33fab3bd00ad710c7f
ToxValDB ECOTOX	LOEL	=15	ppm	Rat	oral	acute; 0.0417 days	acute	LONG_REF=J. Vet. Sci.7(2): 133-136 Manna,S., D. Bhattacharyya, T.K. Mandal, and S. Dey Neuropharmacological Effects of Deltamethrin in Rats 2006; TITLE=Neuropharmacological Effects of Deltamethrin in Rats; AUTHOR=Manna,S., D. Bhattacharyya, T.K. Mandal, and S. Dey; DOI=10.4142/jvs.2006.7.2.133; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109854; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Behavior: Coordination; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15595287:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=318d234adc3d725b9ee304d3f39e9efb
ToxValDB ECOTOX	LOEL	=5	mg/kg bw/day	Rat	injection	0 days	acute	LONG_REF=Toxicol. Appl. Pharmacol.98(3): 398-412 Joy,R.M., T.E. Albertson, and D.E. Ray Type I and Type II Pyrethroids Increase Inhibition in the Hippocampal Dentate gyrus of the Rat 1989; TITLE=Type I and Type II Pyrethroids Increase Inhibition in the Hippocampal Dentate gyrus of the Rat; AUTHOR=Joy,R.M., T.E. Albertson, and D.E. Ray; DOI=10.1016/0041-008x(89)90169-5; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=109515; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Physiology: Electrophysiological response; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595573_15595574:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=15216adb4109b89baea55d7204dc7ea0
ToxValDB ECOTOX	LOEL	=6.25	mg/kg bw/day	Rat	oral	short-term; 10 days	short-term	LONG_REF=Biomed. Environ. Sci.19(1): 27-34 Liu,G.P., Q. Ma, and N. Shi Tyrosine Hydroxylase as a Target for Deltamethrin in the Nigrostriatal Dopaminergic Pathway 2006; TITLE=Tyrosine Hydroxylase as a Target for Deltamethrin in the Nigrostriatal Dopaminergic Pathway; AUTHOR=Liu,G.P., Q. Ma, and N. Shi; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109643; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Homovanillic acid|Enzyme(s): Tyrosine hydroxylase|Genetics: Messenger RNA; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596004_15605140_15605141:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9e53584d4cf7322faa4cb9f084a0d5b0
ToxValDB ECOTOX	LOEL	=4.8	mg/kg bw/day	Rat	oral	subchronic; 42 days	subchronic	LONG_REF=Teratog. Carcinog. Mutagen.12(6): 269-276 Hakoi,K., R. Cabral, T. Hoshiya, R. Hasegawa, T. Shirai, and N. Ito Analysis of Carcinogenic Activity of Some Pesticides in a Medium-Term Liver Bioassay in the Rat 1992; TITLE=Analysis of Carcinogenic Activity of Some Pesticides in a Medium-Term Liver Bioassay in the Rat; AUTHOR=Hakoi,K., R. Cabral, T. Hoshiya, R. Hasegawa, T. Shirai, and N. Ito; DOI=10.1002/tcm.1770120605; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76881; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Placental gultathione S-transferase foci|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596271_15601659:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=076d1f2bbf162c50e870e1653dc51d40
ToxValDB ECOTOX	LOEL	=12.5	mg/kg bw/day	Rat	injection	acute; 0.2083 days	acute	LONG_REF=Environ. Toxicol. Pharmacol.8(3): 183-189 Wu,A., and Y. Liu Deltamethrin Induces Delayed Apoptosis and Altered Expression of P53 and Bax in Rat Brain 2000; TITLE=Deltamethrin Induces Delayed Apoptosis and Altered Expression of P53 and Bax in Rat Brain; AUTHOR=Wu,A., and Y. Liu; DOI=10.1016/s1382-6689(00)00039-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109519; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Genetics: bax mRNA; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15596296:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7b6a268c4e4964e81e75e3fafd0de7aa
ToxValDB ECOTOX	LOEL	=10	mg/kg bw/day	Rat	oral	acute; 0.2083 days	acute	LONG_REF=Brain Res.477(1/2): 314-321 Gilbert,M.E., C.M. Mack, and K.M. Crofton Pyrethroids and Enhanced Inhibition in the Hippocampus of the Rat 1989; TITLE=Pyrethroids and Enhanced Inhibition in the Hippocampus of the Rat; AUTHOR=Gilbert,M.E., C.M. Mack, and K.M. Crofton; DOI=10.1016/0006-8993(89)91420-0; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=93039; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Physiology: P amplitude; STUDY_GROUP=ECOTOX:15596879:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3b8861b06ee42bf18861d6039c7d969d
ToxValDB ECOTOX	LOEL	=0.5	ppm	Rat	oral	short-term; 26 days	reproduction developmental	LONG_REF=Toxicol. Appl. Pharmacol.214(3): 279-289 Johri,A., A. Dhawan, R.L. Singh, and D. Parmar Effect of Prenatal Exposure of Deltamethrin on the Ontogeny of Xenobiotic Metabolizing Cytochrome P450s in the Brain and Liver of Offsprings 2006; TITLE=Effect of Prenatal Exposure of Deltamethrin on the Ontogeny of Xenobiotic Metabolizing Cytochrome P450s in the Brain and Liver of Offsprings; AUTHOR=Johri,A., A. Dhawan, R.L. Singh, and D. Parmar; DOI=10.1016/j.taap.2006.01.006; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=94713; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P450 2E1; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15597302:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b18d23ecd8c36c6de4760af9e28f736c
ToxValDB ECOTOX	LOEL	=90	mg/kg bw/day	Mouse	injection	short-term; 2 days	short-term	LONG_REF=Mutat. Res.518(2): 145-150 Grisolia,C.K. A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides 2002; TITLE=A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides; AUTHOR=Grisolia,C.K.; DOI=10.1016/s1383-5718(02)00086-4; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=74478; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597426_15597427:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2549c1b77632778f7added3a22d159b7
ToxValDB ECOTOX	LOEL	=1	mg/kg bw/day	Rat	injection	acute; 0.0035 days	acute	LONG_REF=Pestic. Biochem. Physiol.25(1): 19-30 Staatz-Benson,C.G., and M.J. Hosko Interaction of Pyrethroids with Mammalian Spinal Neurons 1986; TITLE=Interaction of Pyrethroids with Mammalian Spinal Neurons; AUTHOR=Staatz-Benson,C.G., and M.J. Hosko; DOI=10.1016/0048-3575(86)90028-3; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=114005; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Physiology: Electrophysiological response; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15597453:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dc70f8ff12436c502ae324197ec22338
ToxValDB ECOTOX	LOEL	=0.005	ml/kg	Rat	dermal	short-term; 28 days	short-term	LONG_REF=Egypt. J. Food Sci.16(1-2): 79-86 Mohamed,Z.A. Changes in Rat Blood Profile and Blood Chemistry After Repeated Dermal Application of Fenvalerate and Decamethrin 1988; TITLE=Changes in Rat Blood Profile and Blood Chemistry After Repeated Dermal Application of Fenvalerate and Decamethrin; AUTHOR=Mohamed,Z.A.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92828; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Biochemistry: Bilirubin|Cell(s): Red blood cell; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597490_15599127:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4d41de374554c613b22f549ba948f578
ToxValDB ECOTOX	LOEL	=1000	mg/kg bw/day	Rat	oral	acute; 0.0208 days	acute	LONG_REF=Neurotoxicol. Teratol.17(4): 489-495 Crofton,K.M., L.S. Kehn, and M.E. Gilbert Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat 1995; TITLE=Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat; AUTHOR=Crofton,K.M., L.S. Kehn, and M.E. Gilbert; DOI=10.1016/0892-0362(95)00008-f; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=48434; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Movements, number of; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597971_15599535:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cc50ae7ba525d5776b69d0a2b19e0813
ToxValDB ECOTOX	LOEL	=50	ppm	Rat	injection	short-term; 7 days	short-term	LONG_REF=J. Neurol., Neurosurg. Psychiatry45(11): 1005-1011 Takahashi,M., and P.M. Le Quesne The Effects of the Pyrethroids Deltamethrin and Cismethrin on Nerve Excitability in Rats 1982; TITLE=The Effects of the Pyrethroids Deltamethrin and Cismethrin on Nerve Excitability in Rats; AUTHOR=Takahashi,M., and P.M. Le Quesne; DOI=10.1136/jnnp.45.11.1005; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=110031; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Physiology: Electrophysiological response; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599235_15599236:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=de2952cbf43da76185ceadcee010734e
ToxValDB ECOTOX	LOEL	=0.15	mg/kg bw/day	Rat	injection	short-term; 7 days	short-term	LONG_REF=Toxicology49(2-3): 263-270 De Boer,S.F., J. Van der Gugten, J.L. Slangen, and T.H. Hijzen Changes in Plasma Corticosterone and Catecholamine Contents Induced by Low Doses of Deltamethrin in Rats 1988; TITLE=Changes in Plasma Corticosterone and Catecholamine Contents Induced by Low Doses of Deltamethrin in Rats; AUTHOR=De Boer,S.F., J. Van der Gugten, J.L. Slangen, and T.H. Hijzen; DOI=10.1016/0300-483x(88)90007-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109649; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599268_15599269_15603586:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9a77e8e717b87c1d70dec9bb4bb8231e
ToxValDB ECOTOX	LOEL	=0.08	mg/kg bw/day	Rat	oral	subchronic; 76 days	reproduction developmental	LONG_REF=Neurotoxicol. Teratol.23(6): 665-673 Lazarini,C.A., J.C. Florio, I.P. Lemonica, and M.M. Bernardi Effects of Prenatal Exposure to Deltamethrin on Forced Swimming Behavior, Motor Activity, and Striatal Dopamine Levels in Male and Female Rats 2001; TITLE=Effects of Prenatal Exposure to Deltamethrin on Forced Swimming Behavior, Motor Activity, and Striatal Dopamine Levels in Male and Female Rats; AUTHOR=Lazarini,C.A., J.C. Florio, I.P. Lemonica, and M.M. Bernardi; DOI=10.1016/s0892-0362(01)00170-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109687; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Behavior: Swimming; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599568_15608400:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=95f8d460527d4f18c6fe15b1b41529b4
ToxValDB ECOTOX	LOEL	=0.6	mg/kg bw/day	Rat	oral	subchronic; 60 days	subchronic	LONG_REF=Exp. Toxicol. Pathol.64(7/8): 813-819 Oda,S.S., and Z.K. El-Maddawy Protective Effect of Vitamin E and Selenium Combination on Deltamethrin-Induced Reproductive Toxicity in Male Rats 2012; TITLE=Protective Effect of Vitamin E and Selenium Combination on Deltamethrin-Induced Reproductive Toxicity in Male Rats; AUTHOR=Oda,S.S., and Z.K. El-Maddawy; DOI=10.1016/j.etp.2011.03.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=157500; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Hormone(s): Testosterone|Morphology: Organ weight in relationship to body weight|Reproduction: Sperm cell counts; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight|other|reproduction; STUDY_GROUP=ECOTOX:15599602:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e53951870296fde37ad437ddd7bab79d
ToxValDB ECOTOX	LOEL	=2	mg/kg bw/day	Rat	oral	short-term; 21 days	developmental	LONG_REF=Regul. Toxicol. Pharmacol.36(3): 310-317 Andrade,A.J.M., S. Araujo, G.M. Santana, M. Ohi, and P.R. Dalsenter Reproductive Effects of Deltamethrin on Male Offspring of Rats Exposed During Pregnancy and Lactation 2002; TITLE=Reproductive Effects of Deltamethrin on Male Offspring of Rats Exposed During Pregnancy and Lactation; AUTHOR=Andrade,A.J.M., S. Araujo, G.M. Santana, M. Ohi, and P.R. Dalsenter; DOI=10.1006/rtph.2002.1586; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109670; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599960_15599961:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fd9803b494c3ba44799e502d08799408
ToxValDB ECOTOX	LOEL	=4	mg/kg bw/day	Mouse	dermal	acute; 1 days	acute	LONG_REF=J. Toxicol. Sci.38(4): 629-642 George,J., and Y. Shukla Early Changes in Proteome Levels upon Acute Deltamethrin Exposure in Mammalian Skin System Associated with Its Neoplastic Transformation Potential 2013; TITLE=Early Changes in Proteome Levels upon Acute Deltamethrin Exposure in Mammalian Skin System Associated with Its Neoplastic Transformation Potential; AUTHOR=George,J., and Y. Shukla; DOI=10.2131/jts.38.629; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=168350; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Genetics: Gene expression; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15599997:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3bf70ed6c5b1ea35d584f633297dd50c
ToxValDB ECOTOX	LOEL	=0.172	mg/kg bw/day	Dog	injection	acute; 0.0208 days	acute	LONG_REF=Ph.D.Thesis, Iowa State University, Ames, IA:120 p. Drues,M.E. Transcranial Doppler Sonography: A New Noninvasive Method for Measuring Toxicant-Induced Alterations in Cerebral Blood Flow 1992; TITLE=Transcranial Doppler Sonography: A New Noninvasive Method for Measuring Toxicant-Induced Alterations in Cerebral Blood Flow; AUTHOR=Drues,M.E.; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=112626; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15600072:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4bcfa5f7d2746e15d806686d9063541a
ToxValDB ECOTOX	LOEL	=1.98	nM/org	Rat	injection	acute; 0.0417 days	acute	LONG_REF=Naunyn-Schmiedeberg\'s Arch. Pharmacol.331(4): 341-346 Brodie,M.E., and J. Opacka Dissociation Between Circling Behaviour and Striatal Dopamine Activity Following Unilateral Deltamethrin Administration to Rats 1985; TITLE=Dissociation Between Circling Behaviour and Striatal Dopamine Activity Following Unilateral Deltamethrin Administration to Rats; AUTHOR=Brodie,M.E., and J. Opacka; DOI=10.1007/BF00500816; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109645; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: 5-Hydroxyindole acetic acid; STUDY_GROUP=ECOTOX:15600163:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=660abb403a659ca6840c1ebf3e1e0443
ToxValDB ECOTOX	LOEL	=5.6	mg/kg bw/day	Rat	injection	short-term; 1.25 days	short-term	LONG_REF=Mutat. Res.311(1): 133-138 Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman Cytogenetic Effects of Deltamethrin on Rat Bone Marrow 1994; TITLE=Cytogenetic Effects of Deltamethrin on Rat Bone Marrow; AUTHOR=Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman; DOI=10.1016/0027-5107(94)90081-7; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109484; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Genetics: Micronuclei|Genetics: Mitotic index (# mitoses/total cells); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600186_15603638_15610343_15610344:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c17d98395b37562db638a0a44b81f9c6
ToxValDB ECOTOX	LOEL	=5.5	mg/kg bw/day	Rat	oral	acute; 0.0833 days	acute	LONG_REF=Toxicol. Appl. Pharmacol.282(2): 184-194 Freeborn,D.L., K.L. McDaniel, V.C. Moser, and D.W. Herr Use of Electroencephalography (EEG) to Assess CNS Changes Produced by Pesticides with Different Modes of Action: Effects of Permethrin, Deltamethrin, Fipronil, Imidacloprid, Carbaryl, and Triadimefon 2015; TITLE=Use of Electroencephalography (EEG) to Assess CNS Changes Produced by Pesticides with Different Modes of Action: Effects of Permethrin, Deltamethrin, Fipronil, Imidacloprid, Carbaryl, and Triadimefon; AUTHOR=Freeborn,D.L., K.L. McDaniel, V.C. Moser, and D.W. Herr; DOI=10.1016/j.taap.2014.11.011; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=168404; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=Physiology: Body temperature; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600589_15600590:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9cbaaa1c857230fc276e274e67b46dc
ToxValDB ECOTOX	LOEL	=18	mg/kg bw/day	Mouse	oral	short-term; 10 days	short-term	LONG_REF=Scand. J. Immunol.73(5): 459-464 Rehman,H., A. Mohan, H. Tabassum, F. Ahmad, S. Rahman, S. Parvez, and S. Raisuddin Deltamethrin Increases Candida albicans Infection Susceptibility in Mice 2011; TITLE=Deltamethrin Increases Candida albicans Infection Susceptibility in Mice; AUTHOR=Rehman,H., A. Mohan, H. Tabassum, F. Ahmad, S. Rahman, S. Parvez, and S. Raisuddin; DOI=10.1111/j.1365-3083.2011.02521.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=157395; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Immunological: Humoral immunity; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15601785:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=59df2b786e23c1caa489ff3e32e4a095
ToxValDB ECOTOX	LOEL	=7.5	mg/kg bw/day	Mouse	oral	short-term; 15 days	short-term	LONG_REF=Pestic. Biochem. Physiol.87(2): 123-130 Eraslan,G., A. Bilgili, D. Essiz, M. Akdogan, and F. Sahindokuyucu The Effects of Deltamethrin on Some Serum Biochemical Parameters in Mice 2007; TITLE=The Effects of Deltamethrin on Some Serum Biochemical Parameters in Mice; AUTHOR=Eraslan,G., A. Bilgili, D. Essiz, M. Akdogan, and F. Sahindokuyucu; DOI=10.1016/j.pestbp.2006.07.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98670; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol|Enzyme(s): Serum glutamate oxalo acetate transaminase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity; STUDY_GROUP=ECOTOX:15602019:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f48fb0b01cdfa356c04a268bf5953f30
ToxValDB ECOTOX	LOEL	=12.8	mg/kg bw/day	Rat	oral	short-term; 21 days	reproduction developmental	LONG_REF=Biomed. Aging Pathol.4(1): 1-8 Mani,V.M., S. Asha, and A.M.M. Sadiq Pyrethroid Deltamethrin-Induced Developmental Neurodegenerative Cerebral Injury and Ameliorating Effect of Dietary Glycoside Naringin in Male Wistar Rats 2014; TITLE=Pyrethroid Deltamethrin-Induced Developmental Neurodegenerative Cerebral Injury and Ameliorating Effect of Dietary Glycoside Naringin in Male Wistar Rats; AUTHOR=Mani,V.M., S. Asha, and A.M.M. Sadiq; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=168341; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=Biochemistry: Ascorbic acid|Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|other; STUDY_GROUP=ECOTOX:15602367:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c34f9ed0ad7d32acadbe6fbb841a0a07
ToxValDB ECOTOX	LOEL	=0.7	mg/kg bw/day	Rat	injection	short-term; 4 days	reproduction developmental	LONG_REF=J. Biosci.22(2): 117-130 Patro,N., S.K. Mishra, M. Chattopadhyay, and I.K. Patro Neurotoxicological Effects of Deltamethrin on the Postnatal Development of Cerebellum of Rat 1997; TITLE=Neurotoxicological Effects of Deltamethrin on the Postnatal Development of Cerebellum of Rat; AUTHOR=Patro,N., S.K. Mishra, M. Chattopadhyay, and I.K. Patro; DOI=10.1007/BF02704726; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109075; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Cell(s): Width|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15603140:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9ee85689760737ac74b90aa26b578818
ToxValDB ECOTOX	LOEL	=0.2955	mg/kg bw/day	Mouse	oral	subchronic; 45 days	subchronic	LONG_REF=Vet. Hum. Toxicol.44(1): 73-75 Yarsan,E., A. Bilgili, M. Kanbur, and S. Celik Effects of Deltamethrin on Lipid Peroxidation in Mice 2002; TITLE=Effects of Deltamethrin on Lipid Peroxidation in Mice; AUTHOR=Yarsan,E., A. Bilgili, M. Kanbur, and S. Celik; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109627; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15603832:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=421cf2f407f33b2694fdcf95cab514f3
ToxValDB ECOTOX	LOEL	=6	mg/kg bw/day	Mouse	oral	subchronic; 70 days	subchronic	LONG_REF=Environ. Res.59(2): 467-475 Lukowicz-Ratajczak,J., and J. Krechniak Effects of Deltamethrin on the Immune System in Mice 1992; TITLE=Effects of Deltamethrin on the Immune System in Mice; AUTHOR=Lukowicz-Ratajczak,J., and J. Krechniak; DOI=10.1016/s0013-9351(05)80049-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109688; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Immunological: Plaque forming cell response; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15603971:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=74d650ada68b6523bec469b19cd258f9
ToxValDB ECOTOX	LOEL	=40000	mg/kg bw/day	Rat	injection	acute; 0.0035 days	acute	LONG_REF=Brain Res.194:278-282 Cremer,J.E., V.J. Cunningham, D.E. Ray, and G.S. Sarna Regional Changes in Brain Glucose Utilization in Rats Given a Pyrethroid Insecticide 1980; TITLE=Regional Changes in Brain Glucose Utilization in Rats Given a Pyrethroid Insecticide; AUTHOR=Cremer,J.E., V.J. Cunningham, D.E. Ray, and G.S. Sarna; DOI=10.1016/0006-8993(80)91344-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=110200; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15604511:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9d7e2b59adbf0c6248692a9c2ec7d76
ToxValDB ECOTOX	LOEL	=0.36	mg/kg bw/day	Mouse	oral	short-term; 21 days	short-term	LONG_REF=Mutat. Res.467(2): 119-127 Shukla,Y., and P. Taneja Mutagenic Evaluation of Deltamethrin Using Rodent Dominant Lethal Assay 2000; TITLE=Mutagenic Evaluation of Deltamethrin Using Rodent Dominant Lethal Assay; AUTHOR=Shukla,Y., and P. Taneja; DOI=10.1016/s1383-5718(00)00027-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109507; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Reproduction: Number of implantations; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15604846:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b705b370bcf258b44a5bc43bb278cd13
ToxValDB ECOTOX	LOEL	=20	mg/kg bw/day	Mouse	oral	acute; 1 days	acute	LONG_REF=Toxicol. Lett.93(2/3): 153-157 Chauhan,L.K.S., D.K. Agarwal, and V. Sundararaman In Vivo Induction of Sister Chromatid Exchange in Mouse Bone Marrow Following Oral Exposure to Commercial Formulations of alpha-Cyano Pyrethroids 1997; TITLE=In Vivo Induction of Sister Chromatid Exchange in Mouse Bone Marrow Following Oral Exposure to Commercial Formulations of alpha-Cyano Pyrethroids; AUTHOR=Chauhan,L.K.S., D.K. Agarwal, and V. Sundararaman; DOI=10.1016/s0378-4274(97)00088-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=76638; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Genetics: sister chromatid exchange; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604945_15604946:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4651377c69f9cd33aa18e2ce085f2558
ToxValDB ECOTOX	LOEL	=12	mg/kg bw/day	Mouse	oral	short-term; 10 days	developmental	LONG_REF=Teratology47(2): 147-157 Beck,S.L. Additional Endpoints and Overview of a Mouse Skeletal Variant Assay for Detecting Exposure to Teratogens 1993; TITLE=Additional Endpoints and Overview of a Mouse Skeletal Variant Assay for Detecting Exposure to Teratogens; AUTHOR=Beck,S.L.; DOI=10.1002/tera.1420470207; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=82909; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Development: Teratogenic measurements; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15606519:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=599952f42267d9be16e1dcd55cc90eff
ToxValDB ECOTOX	LOEL	=0.01	mM	Rat	environmental	acute; 0.125 days	acute	LONG_REF=Andrologia (Berl.)42(4): 254-259 Ben Abdallah,F., K. Hamden, I. Galeraud-Denis, A. El Feki, and L. Keskes-Ammar An In Vitro Study on Reproductive Toxicology of Deltamethrin on Rat Spermatozoa 2010; TITLE=An In Vitro Study on Reproductive Toxicology of Deltamethrin on Rat Spermatozoa; AUTHOR=Ben Abdallah,F., K. Hamden, I. Galeraud-Denis, A. El Feki, and L. Keskes-Ammar; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=157518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde|Enzyme(s): Catalase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606567_15606568_15606569_15606570_15606571:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3ac9ec3302400cd60104e4dadfa488a4
ToxValDB ECOTOX	LOEL	=0.05	mM	Rat	environmental	acute; 0.125 days	acute	LONG_REF=Andrologia (Berl.)42(4): 254-259 Ben Abdallah,F., K. Hamden, I. Galeraud-Denis, A. El Feki, and L. Keskes-Ammar An In Vitro Study on Reproductive Toxicology of Deltamethrin on Rat Spermatozoa 2010; TITLE=An In Vitro Study on Reproductive Toxicology of Deltamethrin on Rat Spermatozoa; AUTHOR=Ben Abdallah,F., K. Hamden, I. Galeraud-Denis, A. El Feki, and L. Keskes-Ammar; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=157518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=Reproduction: Motility; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606567_15606568_15606569_15606570_15606571:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8e2bf790e1ec1a70bfdc611ba4a42e15
ToxValDB ECOTOX	LOEL	=0.1	mM	Rat	environmental	acute; 0.125 days	acute	LONG_REF=Andrologia (Berl.)42(4): 254-259 Ben Abdallah,F., K. Hamden, I. Galeraud-Denis, A. El Feki, and L. Keskes-Ammar An In Vitro Study on Reproductive Toxicology of Deltamethrin on Rat Spermatozoa 2010; TITLE=An In Vitro Study on Reproductive Toxicology of Deltamethrin on Rat Spermatozoa; AUTHOR=Ben Abdallah,F., K. Hamden, I. Galeraud-Denis, A. El Feki, and L. Keskes-Ammar; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=157518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=Morphology: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606567_15606568_15606569_15606570_15606571:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a4f1e0eacaf27b1f4d45811347b9d298
ToxValDB ECOTOX	LOEL	=6.6	mg/kg bw/day	Mouse	oral	acute; 1 days	acute	LONG_REF=Environ. Mol. Mutagen.48(8): 636-643 Chauhan,L.K.S., M. Kumar, B.N. Paul, S.K. Goel, and S.K. Gupta Cytogenetic Effects of Commercial Formulations of Deltamethrin and/or Isoproturon on Human Peripheral Lymphocytes and Mouse Bone Marrow Cells 2007; TITLE=Cytogenetic Effects of Commercial Formulations of Deltamethrin and/or Isoproturon on Human Peripheral Lymphocytes and Mouse Bone Marrow Cells; AUTHOR=Chauhan,L.K.S., M. Kumar, B.N. Paul, S.K. Goel, and S.K. Gupta; DOI=10.1002/em.20330; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109226; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15607002:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6da1ccafc8fa5d0fbb60eddcf4f79b5f
ToxValDB ECOTOX	LOEL	=100	mg/kg bw/day	Rat	oral	acute; 0.0417 days	acute	LONG_REF=Neurotoxicol. Teratol.17(4): 489-495 Crofton,K.M., L.S. Kehn, and M.E. Gilbert Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat 1995; TITLE=Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat; AUTHOR=Crofton,K.M., L.S. Kehn, and M.E. Gilbert; DOI=10.1016/0892-0362(95)00008-f; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=48434; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Movements, number of; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607383_15607939:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6c0cfa0af236a13b31d551a15d5264eb
ToxValDB ECOTOX	LOEL	=11.2	mg/kg bw/day	Rat	oral	short-term; 1.25 days	short-term	LONG_REF=Mutat. Res.311(1): 133-138 Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman Cytogenetic Effects of Deltamethrin on Rat Bone Marrow 1994; TITLE=Cytogenetic Effects of Deltamethrin on Rat Bone Marrow; AUTHOR=Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman; DOI=10.1016/0027-5107(94)90081-7; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109484; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600753_15607428_15607429_15607810:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=19d919a936138b92c0003799a3c8e0c6
ToxValDB ECOTOX	LOEL	=0.3	mg/kg bw/day	Rat	injection	acute; 0.0417 days	acute	LONG_REF=Eur. J. Pharmacol.120(2): 269-273 Devaud,L.L., P. Szot, and T.F. Murray PK 11195 Antagonism of Pyrethroid-Induced Proconvulsant Activity 1986; TITLE=PK 11195 Antagonism of Pyrethroid-Induced Proconvulsant Activity; AUTHOR=Devaud,L.L., P. Szot, and T.F. Murray; DOI=10.1016/0014-2999(86)90499-1; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=93144; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Physiology: Seizure; STUDY_GROUP=ECOTOX:15607728:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5856bcddcde59d4fdedca4211e77c413
ToxValDB ECOTOX	LOEL	=40	mg/kg bw/day	Rat	injection	acute; 0.0194 days	acute	LONG_REF=Neurotoxicology6(3): 1-12 Cremer,J.E., and M.P. Seville Changes in Regional Cerebral Blood Flow and Glucose Metabolism Associated with Symptoms of Pyrethroid Toxicity 1985; TITLE=Changes in Regional Cerebral Blood Flow and Glucose Metabolism Associated with Symptoms of Pyrethroid Toxicity; AUTHOR=Cremer,J.E., and M.P. Seville; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109483; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Physiology: Blood flow; STUDY_GROUP=ECOTOX:15607870:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=705890010c2adaaf2bd124eed01eda08
ToxValDB ECOTOX	LOEL	=0.39	mg/kg bw/day	Rat	oral	chronic; 112 days	chronic	LONG_REF=Cell Biochem. Funct.26(1): 119-124 Tuzmen,N., N. Candan, E. Kaya, and N. Demiryas Biochemical Effects of Chlorpyrifos and Deltamethrin on Altered Antioxidative Defense Mechanisms and Lipid Peroxidation in Rat Liver 2008; TITLE=Biochemical Effects of Chlorpyrifos and Deltamethrin on Altered Antioxidative Defense Mechanisms and Lipid Peroxidation in Rat Liver; AUTHOR=Tuzmen,N., N. Candan, E. Kaya, and N. Demiryas; DOI=10.1002/cbf.1411; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=108976; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15608390:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d245445374ead2fb8048cfc785266a4e
ToxValDB ECOTOX	LOEL	=0.5	mg/kg bw/day	Rat	injection	acute; 0.0417 days	acute	LONG_REF=J. Neurol., Neurosurg. Psychiatry45(11): 1005-1011 Takahashi,M., and P.M. Le Quesne The Effects of the Pyrethroids Deltamethrin and Cismethrin on Nerve Excitability in Rats 1982; TITLE=The Effects of the Pyrethroids Deltamethrin and Cismethrin on Nerve Excitability in Rats; AUTHOR=Takahashi,M., and P.M. Le Quesne; DOI=10.1136/jnnp.45.11.1005; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=110031; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Physiology: Electrophysiological response; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608991_15608992:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=851db6c554c308910eae481dfe94ff03
ToxValDB ECOTOX	LOEL	=0.116	mg/kg bw/day	Rat	injection	short-term; 7 days	short-term	LONG_REF=Bull. Fac. Sci. Cairo Univ.55(1): 145-158 Ahmed,N.A., M.M. Fathi, and S.M. Rawi Effect of Organophosphorus and Pyrethroid Compounds on Cholinesterase Activity in Different Brain and Spinal Cord Areas of Albino Rat 1987; TITLE=Effect of Organophosphorus and Pyrethroid Compounds on Cholinesterase Activity in Different Brain and Spinal Cord Areas of Albino Rat; AUTHOR=Ahmed,N.A., M.M. Fathi, and S.M. Rawi; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109592; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Enzyme(s): Cholinesterase; TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter; STUDY_GROUP=ECOTOX:15609033:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=536fe486c746428761f80d904e435923
ToxValDB ECOTOX	LOEL	=357.14	mg/kg bw/day	Rat	injection	short-term; 17.0417 days	short-term	LONG_REF=J. Environ. Pathol. Toxicol. Oncol.14(1): 45-52 Villarini,M., M. Moretti, G. Scassellati-Sforzolini, S. Monarca, R. Pasquini, M.G. Crea, and C. Leonardis Studies on Hepatic Xenobiotic-Metabolizing Enzymes in Rats Treated with Insecticide Deltamethrin 1995; TITLE=Studies on Hepatic Xenobiotic-Metabolizing Enzymes in Rats Treated with Insecticide Deltamethrin; AUTHOR=Villarini,M., M. Moretti, G. Scassellati-Sforzolini, S. Monarca, R. Pasquini, M.G. Crea, and C. Leonardis; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=55231; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Enzyme(s): NADPH-cytochrome p-450 reductase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609420_15609421_15610499:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4ee6ab12e4685d87243e38ad4077f7e9
ToxValDB ECOTOX	LOEL	=13.93	mg/kg bw/day	Mouse	oral	acute; 1 days	acute	LONG_REF=J. Adv. Zool.18(1): 51-53 Chawla,R. Laboratory Evaluation of K-Othrine, a Synthetic Pyrethroid Against Swiss Albino Mice 1997; TITLE=Laboratory Evaluation of K-Othrine, a Synthetic Pyrethroid Against Swiss Albino Mice; AUTHOR=Chawla,R.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109758; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15609855:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1ecd03bb1e95d99fa0d2f0708a044dc6
ToxValDB ECOTOX	LOEL	=150	ppm	Rat	oral	acute; 0.25 days	acute	LONG_REF=J. Vet. Sci.7(2): 133-136 Manna,S., D. Bhattacharyya, T.K. Mandal, and S. Dey Neuropharmacological Effects of Deltamethrin in Rats 2006; TITLE=Neuropharmacological Effects of Deltamethrin in Rats; AUTHOR=Manna,S., D. Bhattacharyya, T.K. Mandal, and S. Dey; DOI=10.4142/jvs.2006.7.2.133; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109854; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: gamma-Aminobutyric acid; STUDY_GROUP=ECOTOX:15609916:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=82e0f3b575f74dd98aabf3d44c7fdb50
ToxValDB ECOTOX	LOEL	=162.5	mg/kg bw/day	Mouse	injection	short-term; 1.25 days	short-term	LONG_REF=Mutat. Res.346(4): 203-206 Gandhi,G., J.B. Chowdhury, P.K. Sareen, and V.P.S. Dhillon Genotoxic Effects of Deltamethrin in the Mouse Bone Marrow Micronucleus Assay 1995; TITLE=Genotoxic Effects of Deltamethrin in the Mouse Bone Marrow Micronucleus Assay; AUTHOR=Gandhi,G., J.B. Chowdhury, P.K. Sareen, and V.P.S. Dhillon; DOI=10.1016/0165-7992(95)90036-5; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109856; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610554_15610671:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6d9adee46cdf9e261c2d0cbd3dd7a64e
ToxValDB ECOTOX	LOEL	=300	mg/kg bw/day	Rat	oral	acute; 8 hours	acute	LONG_REF=Neurotoxicol. Teratol.17(4): 489-495 Crofton,K.M., L.S. Kehn, and M.E. Gilbert Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat 1995; TITLE=Vehicle and Route Dependent Effects of a Pyrethroid Insecticide, Deltamethrin, on Motor Function in the Rat; AUTHOR=Crofton,K.M., L.S. Kehn, and M.E. Gilbert; DOI=10.1016/0892-0362(95)00008-f; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=48434; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Movements, number of; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611253_15611350_15611358:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2ab26ca1e28a90f5b7dc99f018334d68
ToxValDB ECOTOX	NOEL	=5000	mg/kg bw/day	Mouse	oral	short-term; 28 days	short-term	LONG_REF=Int. J. Tissue React.6(2): 127-133 Pham Huu,C., C. Navarro-Delmasure, A. Pham Huu Chanh, P. Clavel, G. Van Haverbeke, and S.L. Cheav Toxicological Studies of Deltamethrin 1984; TITLE=Toxicological Studies of Deltamethrin; AUTHOR=Pham Huu,C., C. Navarro-Delmasure, A. Pham Huu Chanh, P. Clavel, G. Van Haverbeke, and S.L. Cheav; QUALITY=Control type: Control data is presented but without accompanying methodology; EXTERNAL_SOURCE_ID=111114; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594140:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e396cfe9c1f66e8bf95990e244ce1cb8
ToxValDB ECOTOX	NOEL	=0.01	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Fresenius Environ. Bull.5(7/8): 380-385 Shepelskaya,N.R. The Effect of Pesticides Decis, Polyram, 2,4-D Complex on the Reproductive System. Communication 1. Reproductive Toxicity of Decis 1996; TITLE=The Effect of Pesticides Decis, Polyram, 2,4-D Complex on the Reproductive System. Communication 1. Reproductive Toxicity of Decis; AUTHOR=Shepelskaya,N.R.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=93916; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Reproduction: Pre-implantation loss; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594145_15594146_15595496:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=44ca4a22905321909daf16b3864fe3e1
ToxValDB ECOTOX	NOEL	=7	mg/kg bw/day	Rat	oral	short-term; 15 days	short-term	LONG_REF=J. Toxicol. Environ. Health48(5): 515-526 Husain,R., V.M. Adhami, and P.K. Seth Behavioral, Neurochemical, and Neuromorphological Effects of Deltamethrin in Adult Rats 1996; TITLE=Behavioral, Neurochemical, and Neuromorphological Effects of Deltamethrin in Adult Rats; AUTHOR=Husain,R., V.M. Adhami, and P.K. Seth; DOI=10.1080/009841096161212; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109482; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594270_15597871:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=03c6c60356367cbc772e41ea2ea010fe
ToxValDB ECOTOX	NOEL	=0.09792	mg/kg bw/day	Rat	oral	subchronic; 60 days	subchronic	LONG_REF=Chem.-Biol. Interact.206(2): 302-308 Liang,Y.J., H.P. Wang, D.X. Long, W. Li, and Y.J. Wu A Metabonomic Investigation of the Effects of 60 Days Exposure of Rats to Two Types of Pyrethroid Insecticides 2013; TITLE=A Metabonomic Investigation of the Effects of 60 Days Exposure of Rats to Two Types of Pyrethroid Insecticides; AUTHOR=Liang,Y.J., H.P. Wang, D.X. Long, W. Li, and Y.J. Wu; DOI=10.1016/j.cbi.2013.10.002; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=168405; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Biochemistry: Lactate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594480_15594481:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=72354e5d49666ad7dd28de630003d2d6
ToxValDB ECOTOX	NOEL	=10	mg/kg bw/day	Rat	oral	short-term; 7 days	short-term	LONG_REF=Environ. Toxicol. Pharmacol.7(3): 169-178 Dayal,M., D. Parmar, A. Dhawan, U.N. Dwivedi, J. Doehmer, and P.K. Seth Induction of Rat Brain and Liver Cytochrome P450 1A1/1A2 and 2B1/2B2 Isoenzymes by Deltamethrin 1999; TITLE=Induction of Rat Brain and Liver Cytochrome P450 1A1/1A2 and 2B1/2B2 Isoenzymes by Deltamethrin; AUTHOR=Dayal,M., D. Parmar, A. Dhawan, U.N. Dwivedi, J. Doehmer, and P.K. Seth; DOI=10.1016/s1382-6689(99)00011-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109508; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594654_15594655_15600555_15606215_15606216:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b30ce7c49a1b0bfe7ba610a3849a75b4
ToxValDB ECOTOX	NOEL	=0.48	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=J. Ecophysiol. Occup. Health1(1-2): 219-227 Anand,M., G.S.D. Gupta, M.D. Rana, and R.N. Khanna Deltamethrin Induced Changes in Neuromuscular Transmission in Rats 2001; TITLE=Deltamethrin Induced Changes in Neuromuscular Transmission in Rats; AUTHOR=Anand,M., G.S.D. Gupta, M.D. Rana, and R.N. Khanna; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109631; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Behavior: Distance moved, change in direct movement|Behavior: Horizontal movements|Behavior: Rest|Behavior: Stereotypy|Behavior: Vertical or rearing movements|Behavior: Walk; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594766_15598883_15598884:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9ba369899a33c747fd0a3c23edcd0956
ToxValDB ECOTOX	NOEL	=1	mg/kg bw/day	Rat	oral	acute; 0.125 days	acute	LONG_REF=Neurotoxicology11(1): 73-86 Gilbert,M.E., S.K. Acheson, C.M. Mack, and K.M. Crofton An Examination of the Proconvulsant Actions of Pyrethroid Insecticides Using Pentylenetetrazol and Amygdala Kindling Seizure Models 1990; TITLE=An Examination of the Proconvulsant Actions of Pyrethroid Insecticides Using Pentylenetetrazol and Amygdala Kindling Seizure Models; AUTHOR=Gilbert,M.E., S.K. Acheson, C.M. Mack, and K.M. Crofton; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109626; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594923_15594924:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=350500e6a44b5139ca7ea77110358f3d
ToxValDB ECOTOX	NOEL	=20	mg/kg bw/day	Rat	injection	acute; 0.0417 days	acute	LONG_REF=Toxicol. Appl. Pharmacol.217(1): 25-34 Mubarak Hossain,M., T. Suzuki, N. Sato, I. Sato, T. Takewaki, K. Suzuki, E. Tachikawa, and H. Kobayashi Differential Effects of Pyrethroid Insecticides on Extracellular Dopamine in the Striatum of Freely Moving Rats 2006; TITLE=Differential Effects of Pyrethroid Insecticides on Extracellular Dopamine in the Striatum of Freely Moving Rats; AUTHOR=Mubarak Hossain,M., T. Suzuki, N. Sato, I. Sato, T. Takewaki, K. Suzuki, E. Tachikawa, and H. Kobayashi; DOI=10.1016/j.taap.2006.07.011; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109849; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Physiology: Dopamine uptake; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595231_15595232:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=06ac483b5fbcca9aade84c4798487fb4
ToxValDB ECOTOX	NOEL	=4	mg/kg bw/day	Rat	oral	short-term; 8 days	short-term	LONG_REF=Regul. Toxicol. Pharmacol.35(3): 379-382 Andrade,A.J.M., S. Araujo, G.M. Santana, M. Ohi, and P.R. Dalsenter Screening for In Vivo (Anti)Estrogenic and (Anti)Androgenic Activities of Technical and Formulated Deltamethrin 2002; TITLE=Screening for In Vivo (Anti)Estrogenic and (Anti)Androgenic Activities of Technical and Formulated Deltamethrin; AUTHOR=Andrade,A.J.M., S. Araujo, G.M. Santana, M. Ohi, and P.R. Dalsenter; DOI=10.1006/rtph.2002.1554; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109669; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15595233:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7a62914c19b11437f71de25fe63ca580
ToxValDB ECOTOX	NOEL	=5	mg/kg bw/day	Rat	oral	short-term; 15 days	short-term	LONG_REF=J. Environ. Pathol. Toxicol.2:751-765 Kavlock,R., N. Chernoff, R. Baron, R. Linder, E. Rogers, B. Carver, J. Dilley, and V. Simmon Toxicity Studies with Decamethrin, a Synthetic Pyrethroid Insecticide 1979; TITLE=Toxicity Studies with Decamethrin, a Synthetic Pyrethroid Insecticide; AUTHOR=Kavlock,R., N. Chernoff, R. Baron, R. Linder, E. Rogers, B. Carver, J. Dilley, and V. Simmon; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=37417; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight|Morphology: Supernumerary ribs|Mortality: Mortality|Reproduction: Number of implantations|Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595511_15598791:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3795dabd905795c781764c4e49ae41d7
ToxValDB ECOTOX	NOEL	=2.5	mg/kg bw/day	Rat	injection	0 days	acute	LONG_REF=Toxicol. Appl. Pharmacol.98(3): 398-412 Joy,R.M., T.E. Albertson, and D.E. Ray Type I and Type II Pyrethroids Increase Inhibition in the Hippocampal Dentate gyrus of the Rat 1989; TITLE=Type I and Type II Pyrethroids Increase Inhibition in the Hippocampal Dentate gyrus of the Rat; AUTHOR=Joy,R.M., T.E. Albertson, and D.E. Ray; DOI=10.1016/0041-008x(89)90169-5; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=109515; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Physiology: Electrophysiological response; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595573_15595574:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b0284b3619368407b9c88589ae2b947b
ToxValDB ECOTOX	NOEL	=2	mg/kg bw/day	Rat	injection	acute; 0.0208 days	acute	LONG_REF=Pestic. Biochem. Physiol.25(1): 19-30 Staatz-Benson,C.G., and M.J. Hosko Interaction of Pyrethroids with Mammalian Spinal Neurons 1986; TITLE=Interaction of Pyrethroids with Mammalian Spinal Neurons; AUTHOR=Staatz-Benson,C.G., and M.J. Hosko; DOI=10.1016/0048-3575(86)90028-3; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=114005; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Physiology: Electrophysiological response; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15595936:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dea9b9595c8cf1168bd0391135cebcf5
ToxValDB ECOTOX	NOEL	=12.5	mg/kg bw/day	Rat	oral	acute; 0.1667 days	acute	LONG_REF=Neurotoxicology30(Suppl.1): S1 - S16 Weiner,M.L., M. Nemec, L. Sheets, D. Sargent, and C. Breckenridge Comparative Functional Observational Battery Study of Twelve Commercial Pyrethroid Insecticides in Male Rats Following Acute Oral Exposure 2009; TITLE=Comparative Functional Observational Battery Study of Twelve Commercial Pyrethroid Insecticides in Male Rats Following Acute Oral Exposure; AUTHOR=Weiner,M.L., M. Nemec, L. Sheets, D. Sargent, and C. Breckenridge; DOI=10.1016/j.neuro.2009.08.014; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119956; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Behavior: Grip strength|Physiology: Body temperature; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596432_15596433_15597566_15598885_15598886_15601790:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b2d30a8bdc732fa976fb4d449e06b972
ToxValDB ECOTOX	NOEL	=2.24	mg/kg bw/day	Rat	injection	short-term; 5 days	short-term	LONG_REF=Mutat. Res.311(1): 133-138 Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman Cytogenetic Effects of Deltamethrin on Rat Bone Marrow 1994; TITLE=Cytogenetic Effects of Deltamethrin on Rat Bone Marrow; AUTHOR=Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman; DOI=10.1016/0027-5107(94)90081-7; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109484; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596585_15608430:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2eada7ef6481d4890e42873d851bffd7
ToxValDB ECOTOX	NOEL	=0.7	mg/kg bw/day	Mouse	oral	short-term; 7 days	reproduction developmental	LONG_REF=J. Appl. Toxicol.23(1): 9-18 Pauluhn,J., and G. Schmuck Critical Analysis of Potential Body Temperature Confounders on Neurochemical Endpoints Caused by Direct Dosing and Maternal Separation in Neonatal Mice: A Study of Bioallethrin and Deltamethrin Interactions with Temper 2003; TITLE=Critical Analysis of Potential Body Temperature Confounders on Neurochemical Endpoints Caused by Direct Dosing and Maternal Separation in Neonatal Mice: A Study of Bioallethrin and Deltamethrin Interactions with Temper; AUTHOR=Pauluhn,J., and G. Schmuck; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=80907; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Cell(s): Muscarinic cholinergic receptor; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15596705:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=44eb44f8fe35dfe1c7d5788eaec45c9d
ToxValDB ECOTOX	NOEL	=7.2	mg/kg bw/day	Rat	injection	short-term; 28 days	short-term	LONG_REF=Drug Chem. Toxicol.12(3-4): 173-196 Catinot,R., H. Hoellinger, A. Pfister, M. Sonnier, and M.T. Simon Effects on Rats of Subacute Intoxication with Deltamethrin via an Osmotic Pump 1989; TITLE=Effects on Rats of Subacute Intoxication with Deltamethrin via an Osmotic Pump; AUTHOR=Catinot,R., H. Hoellinger, A. Pfister, M. Sonnier, and M.T. Simon; DOI=10.3109/01480548908999153; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109630; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596893_15603086:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0527728c8e747bda5c5b9d133340022f
ToxValDB ECOTOX	NOEL	=33	mg/kg bw/day	Mouse	injection	short-term; 2 days	short-term	LONG_REF=Mutat. Res.518(2): 145-150 Grisolia,C.K. A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides 2002; TITLE=A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides; AUTHOR=Grisolia,C.K.; DOI=10.1016/s1383-5718(02)00086-4; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=74478; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597426_15597427:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9deb169bc8f8539c76af383a7fcdc5ed
ToxValDB ECOTOX	NOEL	=35	mg/kg bw/day	Rat	oral	acute; 0.1667 days	acute	LONG_REF=Neurotoxicology30(Suppl.1): S1 - S16 Weiner,M.L., M. Nemec, L. Sheets, D. Sargent, and C. Breckenridge Comparative Functional Observational Battery Study of Twelve Commercial Pyrethroid Insecticides in Male Rats Following Acute Oral Exposure 2009; TITLE=Comparative Functional Observational Battery Study of Twelve Commercial Pyrethroid Insecticides in Male Rats Following Acute Oral Exposure; AUTHOR=Weiner,M.L., M. Nemec, L. Sheets, D. Sargent, and C. Breckenridge; DOI=10.1016/j.neuro.2009.08.014; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119956; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596432_15596433_15597566_15598885_15598886_15601790:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b83f3dd5c06cc0a000862c70f9a5105e
ToxValDB ECOTOX	NOEL	=0.08	mg/kg bw/day	Rat	oral	subchronic; 37 days	developmental	LONG_REF=Neurotoxicol. Teratol.23(6): 665-673 Lazarini,C.A., J.C. Florio, I.P. Lemonica, and M.M. Bernardi Effects of Prenatal Exposure to Deltamethrin on Forced Swimming Behavior, Motor Activity, and Striatal Dopamine Levels in Male and Female Rats 2001; TITLE=Effects of Prenatal Exposure to Deltamethrin on Forced Swimming Behavior, Motor Activity, and Striatal Dopamine Levels in Male and Female Rats; AUTHOR=Lazarini,C.A., J.C. Florio, I.P. Lemonica, and M.M. Bernardi; DOI=10.1016/s0892-0362(01)00170-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109687; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598014:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=add1383069b51c3b485a6ae9842b0786
ToxValDB ECOTOX	NOEL	=25	mg/kg bw/day	Mouse	oral	short-term; 28 days	short-term	LONG_REF=AAEM Ann. Agric. Environ. Med.8(2): 245-254 Tos-Luty,S., A. Haratym-Maj, J. Latuszynska, D. Obuchowska-Przebirowska, and M. Tokarska-Rodak Oral Toxicity of Deltamethrin and Fenvalerate in Swiss Mice 2001; TITLE=Oral Toxicity of Deltamethrin and Fenvalerate in Swiss Mice; AUTHOR=Tos-Luty,S., A. Haratym-Maj, J. Latuszynska, D. Obuchowska-Przebirowska, and M. Tokarska-Rodak; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=92824; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Biochemistry: Hematocrit (anemia)|Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15598273:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=38794c2fdcdcab39ae852d0c3a777ab4
ToxValDB ECOTOX	NOEL	=1.28	mg/kg bw/day	Rat	oral	short-term; 28 days	short-term	LONG_REF=Bull. Environ. Contam. Toxicol.91(3): 334-338 Dubey,N., A.M. Khan, and R. Raina Sub-Acute Deltamethrin and Fluoride Toxicity Induced Hepatic Oxidative Stress and Biochemical Alterations in Rats 2013; TITLE=Sub-Acute Deltamethrin and Fluoride Toxicity Induced Hepatic Oxidative Stress and Biochemical Alterations in Rats; AUTHOR=Dubey,N., A.M. Khan, and R. Raina; DOI=10.1007/s00128-013-1052-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=168349; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde|Enzyme(s): Acid phosphatase|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598440_15598441:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=121c76488cfc0f49d7bfd93baf9effcb
ToxValDB ECOTOX	NOEL	=10000	mg/kg bw/day	Rat	oral	short-term; 28 days	short-term	LONG_REF=Int. J. Tissue React.6(2): 127-133 Pham Huu,C., C. Navarro-Delmasure, A. Pham Huu Chanh, P. Clavel, G. Van Haverbeke, and S.L. Cheav Toxicological Studies of Deltamethrin 1984; TITLE=Toxicological Studies of Deltamethrin; AUTHOR=Pham Huu,C., C. Navarro-Delmasure, A. Pham Huu Chanh, P. Clavel, G. Van Haverbeke, and S.L. Cheav; QUALITY=Control type: Control data is presented but without accompanying methodology; EXTERNAL_SOURCE_ID=111114; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Morphology: Weight|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|other; STUDY_GROUP=ECOTOX:15598768:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=41775d552f1c8afb8e175f6f152b4d86
ToxValDB ECOTOX	NOEL	=0.192	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=J. Ecophysiol. Occup. Health1(1-2): 219-227 Anand,M., G.S.D. Gupta, M.D. Rana, and R.N. Khanna Deltamethrin Induced Changes in Neuromuscular Transmission in Rats 2001; TITLE=Deltamethrin Induced Changes in Neuromuscular Transmission in Rats; AUTHOR=Anand,M., G.S.D. Gupta, M.D. Rana, and R.N. Khanna; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=109631; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Physiology: Electroencephalogram; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594766_15598883_15598884:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ae2f883ec5855ab67e85cd3ba90dd270
ToxValDB ECOTOX	NOEL	=25	ppm	Rat	injection	short-term; 7 days	short-term	LONG_REF=J. Neurol., Neurosurg. Psychiatry45(11): 1005-1011 Takahashi,M., and P.M. Le Quesne The Effects of the Pyrethroids Deltamethrin and Cismethrin on Nerve Excitability in Rats 1982; TITLE=The Effects of the Pyrethroids Deltamethrin and Cismethrin on Nerve Excitability in Rats; AUTHOR=Takahashi,M., and P.M. Le Quesne; DOI=10.1136/jnnp.45.11.1005; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=110031; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Physiology: Electrophysiological response; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599235_15599236:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a7aeac3c9f2102c762ecb90f04358a9
ToxValDB ECOTOX	NOEL	=0.05	mg/kg bw/day	Rat	injection	short-term; 7 days	short-term	LONG_REF=Toxicology49(2-3): 263-270 De Boer,S.F., J. Van der Gugten, J.L. Slangen, and T.H. Hijzen Changes in Plasma Corticosterone and Catecholamine Contents Induced by Low Doses of Deltamethrin in Rats 1988; TITLE=Changes in Plasma Corticosterone and Catecholamine Contents Induced by Low Doses of Deltamethrin in Rats; AUTHOR=De Boer,S.F., J. Van der Gugten, J.L. Slangen, and T.H. Hijzen; DOI=10.1016/0300-483x(88)90007-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109649; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599268_15599269_15603586:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0af91d5250628b2a14d8f6b6755b7167
ToxValDB ECOTOX	NOEL	=0.99	mg/kg bw/day	Rat	oral	acute; 0.0833 days	acute	LONG_REF=Toxicol. Sci.89(1): 271-277 Wolansky,M.J., C. Gennings, and K.M. Crofton Relative Potencies for Acute Effects of Pyrethroids on Motor Function in Rats 2006; TITLE=Relative Potencies for Acute Effects of Pyrethroids on Motor Function in Rats; AUTHOR=Wolansky,M.J., C. Gennings, and K.M. Crofton; DOI=10.1093/toxsci/kfj020; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=83149; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Behavior: Movements, number of; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15599388:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5972d7591f0ede0bc4abba27cc75a230
ToxValDB ECOTOX	NOEL	=0.25	mg/kg bw/day	Rat	oral	subchronic; 38 days	reproduction developmental	LONG_REF=Eur. J. Pharmacol.544(1-3): 58-68 Johri,A., S. Yadav, R.L. Singh, A. Dhawan, M. Ali, and D. Parmar Long Lasting Effects of Prenatal Exposure to Deltamethrin on Cerebral and Hepatic Cytochrome P450s and Behavioral Activity in Rat Offspring 2006; TITLE=Long Lasting Effects of Prenatal Exposure to Deltamethrin on Cerebral and Hepatic Cytochrome P450s and Behavioral Activity in Rat Offspring; AUTHOR=Johri,A., S. Yadav, R.L. Singh, A. Dhawan, M. Ali, and D. Parmar; DOI=10.1016/j.ejphar.2006.06.042; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109074; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Behavior: Rest|Enzyme(s): 7-Ethoxyresorufin O-deethylase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600671_15600672_15604532:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b3dd79b4248b78c4cd2d620eafd37ac3
ToxValDB ECOTOX	NOEL	=6	mg/kg bw/day	Mouse	injection	short-term; 16 days	short-term	LONG_REF=Pestic. Biochem. Physiol.65(3): 160-168 Kirby,M.L., K. Castagnoli, and J.R. Bloomquist In Vivo Effects of Deltamethrin on Dopamine Neurochemistry and the Role of Augmented Neurotransmitter Release 1999; TITLE=In Vivo Effects of Deltamethrin on Dopamine Neurochemistry and the Role of Augmented Neurotransmitter Release; AUTHOR=Kirby,M.L., K. Castagnoli, and J.R. Bloomquist; DOI=10.1006/pest.1999.2440; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109511; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Biochemistry: 3,4-Dihydroxyphenylacetic acid|Hormone(s): Dopamine; TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600781_15605059:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ac60364a2bc0146022c02dd235e5c095
ToxValDB ECOTOX	NOEL	=3	mg/kg bw/day	Mouse	oral	short-term (developmental); 25 days	developmental	LONG_REF=J. Biochem. Mol. Toxicol.27(2): 165-171 Armstrong,L.E., M.V. Driscoll, V.R. More, A.C. Donepudi, J. Xu, A. Baker, L.M. Aleksunes, J.R. Richardson, and A.L. Sli Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression 2013; TITLE=Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression; AUTHOR=Armstrong,L.E., M.V. Driscoll, V.R. More, A.C. Donepudi, J. Xu, A. Baker, L.M. Aleksunes, J.R. Richardson, and A.L. Sli; DOI=10.1002/jbt.21477; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=168246; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601207_15601208:M:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=83df1cd3b5138b4af00cc077befc65d0
ToxValDB ECOTOX	NOEL	=12	mg/kg bw/day	Mouse	oral	short-term; 12 days	short-term	LONG_REF=J. Environ. Pathol. Toxicol.2:751-765 Kavlock,R., N. Chernoff, R. Baron, R. Linder, E. Rogers, B. Carver, J. Dilley, and V. Simmon Toxicity Studies with Decamethrin, a Synthetic Pyrethroid Insecticide 1979; TITLE=Toxicity Studies with Decamethrin, a Synthetic Pyrethroid Insecticide; AUTHOR=Kavlock,R., N. Chernoff, R. Baron, R. Linder, E. Rogers, B. Carver, J. Dilley, and V. Simmon; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=37417; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight|Mortality: Mortality|Reproduction: Number of implantations|Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601692_15603239:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=63d0f413658eeac703cf4f8206c94e5f
ToxValDB ECOTOX	NOEL	=30	mg/kg bw/day	Mouse	oral	subchronic; 60 days	subchronic	LONG_REF=Pestic. Biochem. Physiol.87(2): 123-130 Eraslan,G., A. Bilgili, D. Essiz, M. Akdogan, and F. Sahindokuyucu The Effects of Deltamethrin on Some Serum Biochemical Parameters in Mice 2007; TITLE=The Effects of Deltamethrin on Some Serum Biochemical Parameters in Mice; AUTHOR=Eraslan,G., A. Bilgili, D. Essiz, M. Akdogan, and F. Sahindokuyucu; DOI=10.1016/j.pestbp.2006.07.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98670; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15601784:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8afbe48d9b260ff445a84a1e1217ed7f
ToxValDB ECOTOX	NOEL	=6.8	mg/kg bw/day	Mouse	oral	short-term; 5 days	short-term	LONG_REF=Mutat. Res.120:167-171 Polakova,H., and M. Vargova Evaluation of the Mutagenic Effects of Decamethrin: Cytogenetic Analysis of Bone Marrow 1983; TITLE=Evaluation of the Mutagenic Effects of Decamethrin: Cytogenetic Analysis of Bone Marrow; AUTHOR=Polakova,H., and M. Vargova; DOI=10.1016/0165-7992(83)90159-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=110584; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15601994:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=232c3f119b856a0a952b90e400bc3810
ToxValDB ECOTOX	NOEL	=8	mg/kg bw/day	Mouse	oral	chronic; 91 days	chronic	LONG_REF=J. Environ. Biol.12(1): 45-50 Gupta,P.K., and S. Kumar Cumulative Toxicity of Deltamethrin in Mice 1991; TITLE=Cumulative Toxicity of Deltamethrin in Mice; AUTHOR=Gupta,P.K., and S. Kumar; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109685; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602714_15607863_15607864:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=aa77d810d8f7263a62d6426e728dc8e1
ToxValDB ECOTOX	NOEL	=11.2	mg/kg bw/day	Rat	injection	short-term; 1.25 days	short-term	LONG_REF=Mutat. Res.311(1): 133-138 Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman Cytogenetic Effects of Deltamethrin on Rat Bone Marrow 1994; TITLE=Cytogenetic Effects of Deltamethrin on Rat Bone Marrow; AUTHOR=Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman; DOI=10.1016/0027-5107(94)90081-7; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109484; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600186_15603638_15610343_15610344:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4809b15c8a22ef71892eaf4c0079bc19
ToxValDB ECOTOX	NOEL	=13.2	mg/kg bw/day	Mouse	oral	acute; 1 days	acute	LONG_REF=Toxicol. Lett.93(2/3): 153-157 Chauhan,L.K.S., D.K. Agarwal, and V. Sundararaman In Vivo Induction of Sister Chromatid Exchange in Mouse Bone Marrow Following Oral Exposure to Commercial Formulations of alpha-Cyano Pyrethroids 1997; TITLE=In Vivo Induction of Sister Chromatid Exchange in Mouse Bone Marrow Following Oral Exposure to Commercial Formulations of alpha-Cyano Pyrethroids; AUTHOR=Chauhan,L.K.S., D.K. Agarwal, and V. Sundararaman; DOI=10.1016/s0378-4274(97)00088-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=76638; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Genetics: sister chromatid exchange; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604945_15604946:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=76cd03165a6b4eff151849f54d98a0b9
ToxValDB ECOTOX	NOEL	=0.36	mg/kg bw/day	Mouse	oral	subchronic; 56 days	subchronic	LONG_REF=Mutat. Res.467(2): 119-127 Shukla,Y., and P. Taneja Mutagenic Evaluation of Deltamethrin Using Rodent Dominant Lethal Assay 2000; TITLE=Mutagenic Evaluation of Deltamethrin Using Rodent Dominant Lethal Assay; AUTHOR=Shukla,Y., and P. Taneja; DOI=10.1016/s1383-5718(00)00027-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109507; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Genetics: Mutation; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15605497:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=10cd15dad258cf5635cf00623cc68360
ToxValDB ECOTOX	NOEL	=15	mg/kg bw/day	Mouse	oral	subchronic; 84 days	subchronic	LONG_REF=Environ. Res.59(2): 467-475 Lukowicz-Ratajczak,J., and J. Krechniak Effects of Deltamethrin on the Immune System in Mice 1992; TITLE=Effects of Deltamethrin on the Immune System in Mice; AUTHOR=Lukowicz-Ratajczak,J., and J. Krechniak; DOI=10.1016/s0013-9351(05)80049-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=109688; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604897_15605545:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c1563c14acc1baa50190f46c3712d378
ToxValDB ECOTOX	NOEL	=8.4	mg/kg bw/day	Rat	oral	short-term; 1.25 days	short-term	LONG_REF=Mutat. Res.311(1): 133-138 Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman Cytogenetic Effects of Deltamethrin on Rat Bone Marrow 1994; TITLE=Cytogenetic Effects of Deltamethrin on Rat Bone Marrow; AUTHOR=Agarwal,D.K., L.K.S. Chauhan, S.K. Gupta, and V. Sundararaman; DOI=10.1016/0027-5107(94)90081-7; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109484; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600753_15607428_15607429_15607810:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=24ff4cbc73680fe54fdaadb57d78e313
ToxValDB ECOTOX	NOEL	=2000	mg/kg bw/day	Mouse	oral	short-term; 28 days	short-term	LONG_REF=Int. J. Tissue React.6(2): 127-133 Pham Huu,C., C. Navarro-Delmasure, A. Pham Huu Chanh, P. Clavel, G. Van Haverbeke, and S.L. Cheav Toxicological Studies of Deltamethrin 1984; TITLE=Toxicological Studies of Deltamethrin; AUTHOR=Pham Huu,C., C. Navarro-Delmasure, A. Pham Huu Chanh, P. Clavel, G. Van Haverbeke, and S.L. Cheav; QUALITY=Control type: Control data is presented but without accompanying methodology; EXTERNAL_SOURCE_ID=111114; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607469_15607470:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=32e0f919ef06e652ec9f0ad4a11b6df0
ToxValDB ECOTOX	NOEL	=3.3	mg/kg bw/day	Mouse	oral	short-term; 30 days	short-term	LONG_REF=Environ. Mol. Mutagen.48(8): 636-643 Chauhan,L.K.S., M. Kumar, B.N. Paul, S.K. Goel, and S.K. Gupta Cytogenetic Effects of Commercial Formulations of Deltamethrin and/or Isoproturon on Human Peripheral Lymphocytes and Mouse Bone Marrow Cells 2007; TITLE=Cytogenetic Effects of Commercial Formulations of Deltamethrin and/or Isoproturon on Human Peripheral Lymphocytes and Mouse Bone Marrow Cells; AUTHOR=Chauhan,L.K.S., M. Kumar, B.N. Paul, S.K. Goel, and S.K. Gupta; DOI=10.1002/em.20330; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109226; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608599:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=78c0d0249b801a34318fdf42c46e37ed
ToxValDB ECOTOX	NOEL	=178.57	mg/kg bw/day	Rat	injection	short-term; 17.0417 days	short-term	LONG_REF=J. Environ. Pathol. Toxicol. Oncol.14(1): 45-52 Villarini,M., M. Moretti, G. Scassellati-Sforzolini, S. Monarca, R. Pasquini, M.G. Crea, and C. Leonardis Studies on Hepatic Xenobiotic-Metabolizing Enzymes in Rats Treated with Insecticide Deltamethrin 1995; TITLE=Studies on Hepatic Xenobiotic-Metabolizing Enzymes in Rats Treated with Insecticide Deltamethrin; AUTHOR=Villarini,M., M. Moretti, G. Scassellati-Sforzolini, S. Monarca, R. Pasquini, M.G. Crea, and C. Leonardis; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=55231; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Enzyme(s): NADPH-cytochrome p-450 reductase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609420_15609421_15610499:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0b3234c3f3baaf9302b2f091e819472b
ToxValDB ECOTOX	NOEL	=32.5	mg/kg bw/day	Mouse	injection	short-term; 1.25 days	short-term	LONG_REF=Mutat. Res.346(4): 203-206 Gandhi,G., J.B. Chowdhury, P.K. Sareen, and V.P.S. Dhillon Genotoxic Effects of Deltamethrin in the Mouse Bone Marrow Micronucleus Assay 1995; TITLE=Genotoxic Effects of Deltamethrin in the Mouse Bone Marrow Micronucleus Assay; AUTHOR=Gandhi,G., J.B. Chowdhury, P.K. Sareen, and V.P.S. Dhillon; DOI=10.1016/0165-7992(95)90036-5; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=109856; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610554_15610671:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a0fdb3e956d9415842680923fdbe0508

ToxValDB EPA OPP 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB EPA OPP	PAD (RfD)	=0.015	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP:15789255:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a12f5a353c26bfad73ec1f63828a79cb

ToxValDB ToxRefDB 22 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB ToxRefDB	LEL	=2.5	mg/kg bw/day	Rat	oral	subchronic; 13 weeks	subchronic	LONG_REF=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.): Huntingdon Research Centre, RSL254/76938/A3, Mar. 21, 1977: EPA Acc. #:. 070736, TAB C-29; TITLE=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.); AUTHOR=Huntingdon Research Centre; EXTERNAL_SOURCE_ID=3440; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-hypersensitivity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15701672_15701673_15701674_15701675:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d126acf7f18f3f83aef22544cb217b5d
ToxValDB ToxRefDB	LEL	=7	mg/kg bw/day	Rat	oral	short-term (developmental); 10 days	reproduction developmental	LONG_REF=Schardein, J. (1990) Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120. Unpublished study prepared by International Research and Development Corp. 140 p.; TITLE=Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120; AUTHOR=Schardein, J; EXTERNAL_SOURCE_ID=3442; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-body surface staining|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-convulsions|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-salivation|systemic: in life observation-clinical signs-anogenital staining|systemic: in life observation-clinical signs-hypersensitivity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701688_15701689_15701690_15701691:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e540eb68c0de915ac5032be487ae419a
ToxValDB ToxRefDB	LEL	>11	mg/kg bw/day	Rat	oral	short-term (developmental); 10 days	developmental	LONG_REF=Schardein, J. (1990) Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120. Unpublished study prepared by International Research and Development Corp. 140 p.; TITLE=Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120; AUTHOR=Schardein, J; EXTERNAL_SOURCE_ID=3442; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ToxRefDB_dup_-_15701692_15701693_15701694_15701695:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ae72c47fd04fd32158803caa5357645b
ToxValDB ToxRefDB	LEL	=32	mg/kg bw/day	Rabbit	oral	short-term (developmental); 23 days	reproduction developmental	LONG_REF=Richard, J. (2001) Deltamethrin: Prenatal Developmental Toxicity Study by Oral Route (Gavage) in Rabbits: Lab Project Number: 21559 RSL. Unpublished study prepared by CIT. 309 p. {OPPTS 870.3700}; TITLE=Deltamethrin: Prenatal Developmental Toxicity Study by Oral Route (Gavage) in Rabbits: Lab Project Number: 21559 RSL; AUTHOR=Richard, J; EXTERNAL_SOURCE_ID=3443; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15701696_15701697_15701698_15701699:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_add98be90b64ff8c33c280cf532ce95e
ToxValDB ToxRefDB	LEL	=23.5	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-ataxia|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-hypersensitivity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701720_15701721_15701722_15701723:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f52f14d041ec80fafd06f394773fcd8a
ToxValDB ToxRefDB	LEL	=21.2	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-alopecia|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-external lesion(s); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15701724_15701725_15701726_15701727:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_351d298a62f33f40423aa3a5d5c8ee8e
ToxValDB ToxRefDB	LEL	=27.2	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology gross-brain-[other]|systemic: in life observation-clinical signs-body surface staining|systemic: pathology gross-skin-lesion(s) (nos)|systemic: in life observation-clinical signs-hyperactivity|systemic: in life observation-clinical signs-ataxia|systemic: in life observation-clinical signs-excessive or spontaneous vocalization|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-salivation|systemic: pathology gross-adrenal gland-enlarged|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-impaired righting reflex|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-discolored digesta|systemic: in life observation-clinical signs-splayed hindlimbs; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701728_15701729_15701730_15701731:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_033957af87bb12ac66b1c95817e96318
ToxValDB ToxRefDB	LEL	=24.9	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-impaired righting reflex|systemic: in life observation-clinical signs-splayed hindlimbs|systemic: in life observation-clinical signs-discolored digesta|systemic: in life observation-clinical signs-body surface staining|systemic: in life observation-clinical signs-ataxia|systemic: pathology gross-brain-[other]|systemic: pathology gross-stomach-erosion|systemic: pathology gross-skin-lesion(s) (nos)|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-salivation|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-hyperactivity|systemic: in life observation-clinical signs-excessive or spontaneous vocalization|systemic: pathology gross-adrenal gland-enlarged; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701732_15701733_15701734_15701735:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6fe8c48e8ea3c1d50e96a602b92c3966
ToxValDB ToxRefDB	LEL	>1.134	mg/kg bw/day	Dog	oral	chronic; 24 months	chronic	LONG_REF=Goldenthal, E.I.; Arceo, R.J.; Brewer, L. (1980) 2-year Chronic Dog Feeding Study: ?RU 22974 (Decametrine)|: IRDC-406-004/A1. (Unpublished study received Mar 25, 1982 under 2E2663; prepared by International Research and Development Corp., submitted by Ame; TITLE=2-year Chronic Dog Feeding Study: ?RU 22974 (Decametrine)|: IRDC-406-004/A1; AUTHOR=Goldenthal, E.I.; Arceo, R.J.; Brewer, L; EXTERNAL_SOURCE_ID=3447; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ToxRefDB_dup_-_15701752_15701753_15701754_15701755:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4456f86a975716ba2218825f173c6c01
ToxValDB ToxRefDB	LEL	=10	mg/kg bw/day	Dog	oral	chronic; 52 weeks	chronic	LONG_REF=Ryle, P.; Path, R.; Path, M. et al. (1993) Deltamethrin: Toxicity to Dogs by Repeated Oral Administration for 52 Weeks: Lab Project Number: RSL 816/920929. Unpublished study prepared by Huntingdon Research Centre, Ltd. 236 p.; TITLE=Deltamethrin: Toxicity to Dogs by Repeated Oral Administration for 52 Weeks: Lab Project Number: RSL 816/920929; AUTHOR=Ryle, P.; Path, R.; Path, M. et al; EXTERNAL_SOURCE_ID=3448; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-chewing of extremities|systemic: in life observation-clinical signs-unwilling to stand/walk|systemic: in life observation-clinical signs-tremors|systemic: in life observation-clinical signs-abnormal gait|systemic: in life observation-clinical signs-watery stools; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15701760_15701761_15701762_15701763:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_61608f28dd45b20e5824585a799fb2bf
ToxValDB ToxRefDB	LEL	>395.1	mg/kg bw/day	Mouse	oral	chronic; 97 weeks	chronic	LONG_REF=Richard, J. (1995) Deltamethrin: 97-Week Carcinogenicity Study by Oral Route (Dietary Admixture) in Mice. Lab Project Number: 7347TCS: A70820: 7347TCS/DELTAMETHRIN. Unpublished study prepared by Centre International de. Toxicologie (C.I.T.). 2041 p.; TITLE=Deltamethrin: 97-Week Carcinogenicity Study by Oral Route (Dietary Admixture) in Mice; AUTHOR=Richard, J; EXTERNAL_SOURCE_ID=3449; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ToxRefDB_dup_-_15701768_15701769_15701770_15701771:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ad9ffad32ac2e6ddc4b2a4ab40fa21ab
ToxValDB ToxRefDB	LEL	>15	mg/kg bw/day	Mouse	oral	chronic; 24 months	chronic	LONG_REF=Goldenthal, E.I.; Arceo, R.J.; Gunderson, G.; et al. (1980) Two- year Oral Toxicity and Carcinogenicity Study in Mice: Ref. IRDC 406-001 A/4. (Unpublished study received Mar 25, 1982 under 2E2663; prepared by International Research and Development Corp.,; TITLE=Two- year Oral Toxicity and Carcinogenicity Study in Mice; AUTHOR=Goldenthal, E.I.; Arceo, R.J.; Gunderson, G.; et al; EXTERNAL_SOURCE_ID=3451; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ToxRefDB_dup_-_15701776_15701777_15701778_15701779:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca512274069df8b1b9588e32342baac6
ToxValDB ToxRefDB	LEL	>47.1	mg/kg bw/day	Rat	oral	chronic; 104 weeks	chronic	LONG_REF=Ryle, P. (1995) Deltamethrin: Potential Tumorigenic and Toxic Effects in Prolonged Dietary Administration to Rats: Lab Project Number: RSL 814: A70821: RSL 814/932275. Unpublished study prepared by Huntingdon Research Centre, Ltd. 3012 p.; TITLE=Deltamethrin: Potential Tumorigenic and Toxic Effects in Prolonged Dietary Administration to Rats: Lab Project Number: RSL 814: A70821: RSL 814/932275; AUTHOR=Ryle, P; EXTERNAL_SOURCE_ID=3452; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ToxRefDB_dup_-_15701784_15701785_15701786_15701787:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7b850bd736e7a1a1031d465bde38cc3c
ToxValDB ToxRefDB	LOAEL	>10	mg/kg bw/day	Rat	oral	subchronic; 13 weeks	subchronic	LONG_REF=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.): Huntingdon Research Centre, RSL254/76938/A3, Mar. 21, 1977: EPA Acc. #:. 070736, TAB C-29; TITLE=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.); AUTHOR=Huntingdon Research Centre; EXTERNAL_SOURCE_ID=3440; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ToxRefDB_dup_-_15701672_15701673_15701674_15701675:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66a6b6004f175d4ee0e2dbcb5d6899d2
ToxValDB ToxRefDB	LOAEL	=50	mg/kg bw/day	Dog	oral	chronic; 52 weeks	chronic	LONG_REF=Ryle, P.; Path, R.; Path, M. et al. (1993) Deltamethrin: Toxicity to Dogs by Repeated Oral Administration for 52 Weeks: Lab Project Number: RSL 816/920929. Unpublished study prepared by Huntingdon Research Centre, Ltd. 236 p.; TITLE=Deltamethrin: Toxicity to Dogs by Repeated Oral Administration for 52 Weeks: Lab Project Number: RSL 816/920929; AUTHOR=Ryle, P.; Path, R.; Path, M. et al; EXTERNAL_SOURCE_ID=3448; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-unwilling to stand/walk|systemic: in life observation-clinical signs-tremors|systemic: in life observation-clinical signs-abnormal gait; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15701760_15701761_15701762_15701763:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29702f7789dc47bfd78f47e904c6ec6a
ToxValDB ToxRefDB	NEL	=1	mg/kg bw/day	Rat	oral	subchronic; 13 weeks	subchronic	LONG_REF=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.): Huntingdon Research Centre, RSL254/76938/A3, Mar. 21, 1977: EPA Acc. #:. 070736, TAB C-29; TITLE=RU 22974-Assessment of Toxicity to rats by oral administration for 13 weeks (by gavage) (followed by a 4 week withdrawal period.); AUTHOR=Huntingdon Research Centre; EXTERNAL_SOURCE_ID=3440; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-hypersensitivity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15701672_15701673_15701674_15701675:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d90ce4846179036a73a4902ca3a3ba42
ToxValDB ToxRefDB	NEL	=3.3	mg/kg bw/day	Rat	oral	short-term (developmental); 10 days	reproduction developmental	LONG_REF=Schardein, J. (1990) Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120. Unpublished study prepared by International Research and Development Corp. 140 p.; TITLE=Developmental Toxicity Study of Deltamethrin in Rats: Lab Project Number: 327-120; AUTHOR=Schardein, J; EXTERNAL_SOURCE_ID=3442; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-body surface staining|systemic: in life observation-clinical signs-hypersensitivity|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-anogenital staining|systemic: in life observation-clinical signs-convulsions|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-salivation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701688_15701689_15701690_15701691:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4971c090242fa03fa09cfe27068435cb
ToxValDB ToxRefDB	NEL	=10	mg/kg bw/day	Rabbit	oral	short-term (developmental); 23 days	reproduction developmental	LONG_REF=Richard, J. (2001) Deltamethrin: Prenatal Developmental Toxicity Study by Oral Route (Gavage) in Rabbits: Lab Project Number: 21559 RSL. Unpublished study prepared by CIT. 309 p. {OPPTS 870.3700}; TITLE=Deltamethrin: Prenatal Developmental Toxicity Study by Oral Route (Gavage) in Rabbits: Lab Project Number: 21559 RSL; AUTHOR=Richard, J; EXTERNAL_SOURCE_ID=3443; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15701696_15701697_15701698_15701699:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f3b069add245e3a524b4aa0749f2623
ToxValDB ToxRefDB	NEL	=6.1	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-hypersensitivity|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701720_15701721_15701722_15701723:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72529674a51143fa0f492e2aee16bcc2
ToxValDB ToxRefDB	NEL	=5.4	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-alopecia|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-external lesion(s)|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15701724_15701725_15701726_15701727:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afd9082e1d2e3a00dc25fc862c29fa5e
ToxValDB ToxRefDB	NEL	=6.7	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-ataxia|systemic: in life observation-clinical signs-hyperactivity|systemic: pathology gross-skin-lesion(s) (nos)|systemic: in life observation-clinical signs-body surface staining|systemic: pathology gross-brain-[other]|systemic: in life observation-clinical signs-excessive or spontaneous vocalization|systemic: in life observation-clinical signs-salivation|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-splayed hindlimbs|systemic: in life observation-clinical signs-discolored digesta|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-impaired righting reflex|systemic: in life observation-body weight-body weight|systemic: pathology gross-adrenal gland-enlarged; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701728_15701729_15701730_15701731:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d856fa364103966510e139d9f69ade2c
ToxValDB ToxRefDB	NEL	=5.8	mg/kg bw/day	Rat	oral	chronic (developmental)	reproduction developmental	LONG_REF=Hoberman, A. (1992) Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001. AgrEvo A70863: ARGUS 818-001. Unpublished study prepared by Argus Research Labs.; TITLE=Deltamethrin: Reproductive Effects of Deltamethrin Administered Orally in the Diet to Cr1:CDBR VAF/Plus Rats for Two Generations: Lab Project ID 818-001; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=3446; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-discolored digesta|systemic: in life observation-clinical signs-splayed hindlimbs|systemic: pathology gross-skin-lesion(s) (nos)|systemic: in life observation-clinical signs-ataxia|systemic: pathology gross-brain-[other]|systemic: pathology gross-stomach-erosion|systemic: in life observation-clinical signs-body surface staining|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-impaired righting reflex|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-excessive or spontaneous vocalization|systemic: in life observation-clinical signs-hyperactivity|systemic: pathology gross-adrenal gland-enlarged|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-salivation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15701732_15701733_15701734_15701735:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_647883c5075323ae01e4a49a8676ac89

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	2JTS8R821G	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C22H19Br2NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2JTS8R821G"}
openFDA substances	FDA UNII substance identifier	2JTS8R821G	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C22H19Br2NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2JTS8R821G"}
openFDA substances	FDA UNII substance identifier	2JTS8R821G	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C22H19Br2NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2JTS8R821G"}
openFDA substances	FDA UNII substance identifier	2JTS8R821G	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C22H19Br2NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2JTS8R821G"}