NOAEL Studies Cosmetic Ingredient

Denatonium Benzoate NOAEL Studies

INCI: DENATONIUM BENZOATE

CAS: 3734-33-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 0.2 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4707; Record_ID=acute_inhalation_2890; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8034376; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.2; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16728/7/3/3/?documentUUID=0064d18d-3861-452d-bfed-51c2d21acd23; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8034376
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7502; RecordID=ARPathway2016_1175; DatasetName=ARPathway2016; DTXSID=DTXSID8034376; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8034376
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =8 mg/kg bw/day Monkey oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb22e4b0a7c65d224f3a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16728/7/6/2?documentUUID=f67ddda4-b6ce-4e91-be04-59af9ab5db84; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15841019:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_61bd6f17893373ce9053c15c6925c1f6
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rat oral subchronic (developmental); 63 days reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb22e4b0a7c65d224f2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16728/7/6/2?documentUUID=f67ddda4-b6ce-4e91-be04-59af9ab5db84; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15847811:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fc86af32b23c38b5a7dc56777f301d35
ToxValDB_ECHA_IUCLID NOAEL =16 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216dc8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16728/7/8?documentUUID=f67ddda4-b6ce-4e91-be04-59af9ab5db84; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight and weight gain|urinalysis||clinical biochemistry|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|ophthalmological examination|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15820457:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_84cca3de55956f7b6b434c6418895d4e
ToxValDB_ECHA_IUCLID NOAEL =60 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1d0e4b0a7c65d23057b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16728/7/9/3?documentUUID=f67ddda4-b6ce-4e91-be04-59af9ab5db84; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=maternal: clinical biochemistry|maternal: early or late resorptions|maternal: gross pathology|maternal: histopathology: non-neoplastic|maternal: mortality|maternal: necropsy findings|maternal: number of abortions|maternal: organ weights and organ / body weight ratios|maternal: pre and post implantation loss|maternal: total litter losses by resorption; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15824798:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cebceeb23116eb724bd27c85eb4de35c
ToxValDB_ECHA_IUCLID NOAEL =535.896 mg/kg bw/day Mouse oral short-term; 3 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb23e4b0a7c65d224f5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16728/7/6/2?documentUUID=f67ddda4-b6ce-4e91-be04-59af9ab5db84; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15849441:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13b9d03e2f56e5193306f59fcbe698c6
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =2 % Rat environmental short-term; 7 days short-term LONG_REF=J. Wildl. Manag.64(4): 1009-1013 Shumake,S.A., R.T. Sterner, and S.E. Gaddis Repellents to Reduce Cable Gnawing by Wild Norway Rats 2000; TITLE=Repellents to Reduce Cable Gnawing by Wild Norway Rats; AUTHOR=Shumake,S.A., R.T. Sterner, and S.E. Gaddis; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=90264; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Feeding behavior: Feeding behavior; STUDY_GROUP=ECOTOX:15601912:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1f2e2b42a9417e6dc335746eac048894
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =4.99 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630948:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64a685ec78c60d6ef57327717648a7e2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier M5BA6GAF1O UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H29N2O.C7H5O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M5BA6GAF1O"}
openFDA substances FDA UNII substance identifier M5BA6GAF1O UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H29N2O.C7H5O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M5BA6GAF1O"}
openFDA substances FDA UNII substance identifier M5BA6GAF1O UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H29N2O.C7H5O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M5BA6GAF1O"}
openFDA substances FDA UNII substance identifier M5BA6GAF1O UNII - - - chemical {"approval_status":null,"molecular_formula":"C21H29N2O.C7H5O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M5BA6GAF1O"}