NOAEL Studies Cosmetic Ingredient

DIBUTYL PHTHALATE NOAEL Studies

CAS: 84-74-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ATSDR_toxval_ATSDR_MRLs.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ATSDR_toxval_ATSDR_MRLs.xlsx NOAEL =50 mg/kg/day Rat (Sprague Dawley; M/F) oral short-term (developmental); 10 days developmental ATSDR MRLs; row_hash=49e48182f022db72; source_hash=ToxValhc_0f7e31a0d596c7241fd6e428bdf57e81; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=50; raw_unit=mg/kg/day; method=gavage; effect=developmental; effect_category=development; file=toxval_ATSDR_MRLs.xlsx; long_ref=Mylchreest E, Wallace DG, Cattley RC, et al. 2000. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation. Toxicol Sci 55:143-151.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c75
COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 752 mg/kg bw/day rat oral 90 day Subchronic REACH; study report
COSMOS_DB NOAEL 152 mg/kg bw/day rat oral 90 day Subchronic REACH; study report
California Proposition 65 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 MADL AB8.7 ug/day - - 2005-12-02 Maximum allowable dose level {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL AB8.7 ug/day - - 2005-12-02 Maximum allowable dose level {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL AB8.7 ug/day - - 2005-12-02 Maximum allowable dose level {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 MADL AB8.7 ug/day - - 2005-12-02 Maximum allowable dose level {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental, female, male listing type - - 2005-12-02 California Proposition 65 listing {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental, female, male listing type - - 2005-12-02 California Proposition 65 listing {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental, female, male listing type - - 2005-12-02 California Proposition 65 listing {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABdevelopmental, female, male listing type - - 2005-12-02 California Proposition 65 listing {"cancer_reproductive":"developmental, female, male","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"8.7","nsrl":null,"source_table":"prop65_listings"}
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx LOAEL =2 mg/kg bw/day Rat oral: unspecified - reproduction toxicity EFSA AFC - 2005 - OutputID 353 - histopathology non neoplastic - reproductive - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Material in Contact with Food (AFC) on a request from the Commission related to Di-Butylphthalate (DBP) for use in food contact materials - doi:10.2903/j.efsa.2005.242
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA_IRIS_iris_rfd_systems.csv NOAEL =125 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=20f54c4c78cac8c9; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.25e2 mg/kg-day; system=Other; basis=Increased mortality; point_of_departure=NOAEL : 1.25e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID2021781; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=38; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0038_summary.pdf
EPA_IRIS_iris_rfd_systems.csv RfD =0.1 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=69833d9ab0749036; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=1e-1; system=Other; basis=Increased mortality; point_of_departure=NOAEL : 1.25e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID2021781; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=38; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0038_summary.pdf
INCHEM_WHO_ehc_ehc_ehc189 33 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_ehc_ehc_ehc189 ADI =66 mg/kg bw/day Rat - - Health guidance value document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=d4a60ca537acd855; raw_unit=mg/kg body weight per day; context=ADI = 66 mg/kg body weight per day 1000 = 0.066 mg/kg body weight per day = 66 œg/kg body weight per day where: * 66 mg/kg body weight per day is the approximate LOAEL for developmental and reproductive effects in rats observed in the most sensitive studies conducted to date * 1000 is the unce
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =66 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=f09a428ce33d5cc0; raw_unit=mg/kg body weight per day; context=The lowest-observed- adverse-effect-level (LOAEL) was considered to be 66 mg/kg body weight per day.
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =66 mg/kg bw - - - Reproductive toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=5cf9358ead1416db; raw_unit=mg/kg; context=La dose la plus faible sans effet nocif observable (LOAEL) sur la reproduction et le développement a été fixée à 66 mg/kg de poids corporel par jour à la suite d'une étude au cours de laquelle les animaux étaient élevés en continu, avec cette réserve qu'à cette dose, les effets observés étaient modérés et probablement réversibles.
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =250 mg/kg bw/day Rat oral - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=0ca587addeaacfa5; raw_unit=mg/kg; context=Continued Species Protocol Results Effect Levels Reference Rat (Wistar 0, 250, 500 or 1000 mg/kg Significant decrease in testicular weight at 500 LOAEL = 250 mg/kg Srivastava albino, groups b.w. per day by gavage in and 1000 mg/kg b.w. per day.
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =320 mg/kg bw Rat - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=285c5cc8ab7b2703; raw_unit=mg/kg b.w.; context=Continued Species Protocol Results Effect levels Reference Rat 0, 0.32, 0.64 or 1.06 g/kg At all doses, the number of resorptions in LOAEL = 320 mg/kg b.w.
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =322 mg/kg bw/day - - - Reproductive toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=d04f26190dcc52a1; raw_unit=mg/kg; context=Estimated average In high-dose males, significant decrease in the degeneration. daily intakes for exposed absolute weight and relative weight of prostate, LOAEL = 322 mg/kg groups were 50, 247 and 498 right testis and seminal vesicles; significant b.w. per day (low mg/kg b.w. for males and 83, increase in liver and kidney weight. dose group not 397 and 828 mg/kg b.w. for In high-dose males, adverse effect upon epididymal examine
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =500 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=dea6631153b96480; raw_unit=mg/kg body weight per day; context=The LOAEL was considered to be 500 mg/kg body weight per day on the basis of histological changes in the liver and kidneys.
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =750 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=d79e59453923db44; raw_unit=mg/kg b.w.; context=Dosing on days 7 to 9 of Significant increase in number of resorptions, LOAEL = 750 mg/kg b.w. pregnancy - 0, 750, 1000 or dead fetuses per litter; postimplantation per day (teratogenic 1500 mg/kg b.w. per day loss at > 0.75 g/kg b.w. per day (100% effects) postimplantation loss at 1.5 g/kg b.w. per day).
INCHEM_WHO_ehc_ehc_ehc189 LOAEL =1300 mg/kg bw/day - oral - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=2bc18e1fd3306d1b; raw_unit=mg/kg b.w.; context=or 1.0% DBP in per litter, and in the proportion of pups born b.w. per day. et al. (1987); of each sex) the diet (equivalent to 39, alive at the 1.0% amount, but not at lower dose LOAEL = 1.0% in 390, 1300 mg/kg b.w. per levels.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =0.1 mg/L - - 10-day Chronic toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=41bb5fd8d63c70c5; raw_unit=ug/litre; unit_normalization=converted from micrograms; context=nsa Reference Scud (Gammarus pulex) Chronic, 10-day LOEL > 500 ug/litre Thurén & Woin (1991) flow-through (survival) 10-day LOEL 500 ug/litre (decreased locomotor activity) 10-day NOEL 100 ug/litre (decreased locomotor activity) Midge (Chironomus plumosus) Chronic, 30-day LOEL > 560 ug/litre Streufert & Sanders (1977) flow-through (larval emergence) a all concentrations are nominal unless stated otherwise b measured concentration In both laboratory and
INCHEM_WHO_ehc_ehc_ehc189 NOEL =0.5 mg/L - - 21-day Reproductive toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=6e7dc869d16e2a78; raw_unit=ug/litre; unit_normalization=converted from micrograms; context=l and reproduction) 21-day LC 50 1920 ug/litre b DeFoe et al. (1990) 21-day EC 50 1640 ug/litre b (reproduction) 21-day EC 50 1050 ug/litre b (reproduction) Chronic, static 21-day NOEL 500 ug/litre b Kühn et al. (1989) renewal (parent survival) Chronic, static 21-day LOEL 2500 ug/litre b Springborn Bionomics (1984b) renewal (survival and reproduction) Grass shrimp Chronic, static 10-day LC 0 10 mg/kg Clark et al. (1987) (Palaemonetes pugio) (sediment ex
INCHEM_WHO_ehc_ehc_ehc189 NOEL =0.56 mg/L - - 16-day Reproductive toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=bbfbf806d60342f7; raw_unit=ug/litre; unit_normalization=converted from micrograms; context=Continued Species Study type End-point Concentrations a Reference Water flea 16-day NOEL 560 ug/litre (Daphnia magna) (survaval and reproduction) 21-day LC 50 1920 ug/litre b DeFoe et al. (1990) 21-day EC 50 1640 ug/litre b (reproduction) 21-day EC 50 1050 ug/litre b (reproduction) Chronic, static 21-day NOEL 500 ug/litre b Kühn et al. (1989) renewal (parent
INCHEM_WHO_ehc_ehc_ehc189 NOEL =0.96 mg/L - - 7-day Reproductive toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=ed239701b3511efc; raw_unit=ug/litre; unit_normalization=converted from micrograms; context=(1986) (Dugesia japonica) regeneration) Acute, static 7-day LC 50 840 ug/litre (increased abnormalities) Water flea Chronic, 21-day NOEL 960 ug/litre b CMA (1984) (Daphnia magna) flow through (mortality) 21-day LOEL 2500 ug/litre b (mortality) Chronic, static 16-day LOEL 1800 ug/litre McCarthy & Whitmore (1985) renewal (survival and reproduction) Table 13.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =1 mg/m3 Human; Rat - 93 days Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=334af6fcab65ab0e; raw_unit=mg/m 3; context=Rat (strain 0.095, 0.25 and 1 mg/m 3 , 24 h No clinical signs of toxicity were noted during NOEL = 1 mg/m 3 Men'shikova unspecified, per day for 93 days the study; animals appeared healthy and the rate (1971) groups of 15 of body weight gain for treated animals was males) similar to controls.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =27 mg/kg bw/day - oral - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=0f9971708c9ab9c0; raw_unit=mg/kg; context=5 3, 9, 27, 50, 100 or 200 Reduction in relative testicular weight and NOEL = 27 mg/kg Sajiki males and 5 mg/kg b.w. per day in olive increases in leukocyte counts and serum lactate b.w. per day (1975a,b) females per oil by gavage, daily for 30 dehydrogenase activity were observed.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =100 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=bbcc580c9882d6ae; raw_unit=mg/kg body weight per day; context=The NOEL in this study was 100 mg/kg body weight per day.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =104 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=51e11d6cd0a30b9a; raw_unit=mg/kg body weight per day; context=The NOEL values for induction of peroxisome proliferation activity were considered to be 52 and 104 mg/kg body weight per day for DEHP and DBP, respectively.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =120 mg/kg bw Rat - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=e6f02e360544c369; raw_unit=mg/kg b.w.; context=Rat (Wistar, 120 or 600 mg/kg b.w. per No effects on ossification, bone development of NOEL = 120 mg/kg b.w.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =138 mg/kg bw/day - oral - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=0be4d80fb56ba6c6; raw_unit=mg/kg; context=all dose groups and 593 mg/kg b.w. per the diet beginning at day one in females at > 20 000 mg/kg day for females; of gestation, throughout Organ weights: hepatomegaly in males at NOEL is 138 mg/kg gestation, and until weaning. > 5000 mg/kg and in females at > 2500 mg/kg; b.w. per day for Pups had no exposure for four lower testes weight at > 20 000 mg/kg; lower males and 294 mg/kg weeks post-weaning.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =176 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=db1fdcf4fa774e7a; raw_unit=mg/kg body weight per day; context=The LOEL and NOEL values in this study for hepatic peroxisomal proliferation and hepatomegaly were 356 and 176 mg/kg body weight per day, respectively.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =177 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=e195f4ca1ab5432c; raw_unit=mg/kg b.w. per day; context=10 000 mg/kg; elevations in histopathological alkaline phosphatase activity and bile acid lesions in the concentration in both sexes was considered liver indicative of cholestasis NOEL = 177 mg/kg b.w. per day Table 7.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =250 mg/kg bw/day Rat - 75 days Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=f2b84732f3592942; raw_unit=mg/kg body weight per day; context=In a second experiment in the same report, however, half of the breeding pairs of rats exposed to 500 mg/kg body weight per day from 20 to 75 days of age did not breed (NOEL = 250 mg/kg body weight per day).
INCHEM_WHO_ehc_ehc_ehc189 NOEL =279 mg/kg bw/day Rat - subchronic Developmental toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=da71cf06c2d8fa8d; raw_unit=mg/kg body weight per day; context=In a study with combined prenatal perinatal and subchronic exposure (see NTP rat study 3 in Section 7.3), similar effects were observed at doses of > 571 mg/kg body weight (NOEL = 279 mg/kg body weight per day) (NTP, 1995).
INCHEM_WHO_ehc_ehc_ehc189 NOEL =353 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=e1c976aa4dfec0a9; raw_unit=mg/kg body weight per day; context=The LOEL in this study was 812 mg/kg body weight per day, based on decreases in body weight in both sexes and increases in relative liver weight (NOEL = 353 mg/kg body weight per day).
INCHEM_WHO_ehc_ehc_ehc189 NOEL =359 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=1d5fda5b99734d7b; raw_unit=mg/kg body weight per day; context=The NOEL for these effects was 359 mg/kg body weight per day.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =370 mg/kg bw Mouse - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=d8c4ff5a12abed6d; raw_unit=mg/kg b.w.; context=Mouse (ICR-JCL, 0.05, 0.1, 0.2, 0.4 or There was a significant reduction in body NOEL = 370 mg/kg b.w.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =400 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=dbb1f37342b8bd23; raw_unit=mg/kg b.w.; context=A statistically (offspring) be 100 and 400 mg/kg b.w. significant increase in kidney weight was NOEL = 0.05% (100 per day observed in the high-dose group.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =500 mg/kg bw/day - - - Reproductive toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=14f022d2a87eb1ad; raw_unit=mg/kg; context=There were no effects on NOEL = 500 mg/kg (abstract) number 1000 mg/kg b.w. per day from the female reproductive system.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =500 mg/kg bw Rat - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=67a74082e642b757; raw_unit=mg/kg b.w.; context=Continued Species Protocol Results Effect levels Reference Rat, (Wistar, Administered DBP by Significant decrease in maternal body weight NOEL = 500 mg/kg b.w.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =515 mg/kg bw/day Rat oral 6 weeks Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=e6ba43f95e58477c; raw_unit=mg/kg; context=Rat (F-344, 0, 0.05, 0.1, 0.5, 1.0 or Based on histological changes and data on organ NOEL = 515 mg/kg Lake et al. groups of 5 2.5% in the diet for 28 weights, the authors concluded that the NOEL for b.w. per day (1991) males, 6 weeks days (conversions to dose testicular atrophy was 515 mg/kg b.w. per day. (abstract) old) on a body weight basis not No other in
INCHEM_WHO_ehc_ehc_ehc189 NOEL =660 mg/kg bw/day - - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=b144360828f28dc0; raw_unit=mg/kg b.w.; context=hiota & corresponding to 80, 180, similar in exposed and control animals but the per day (offspring) Nishimura 370, 660 and 2100 mg/kg numbers of resorptions and dead fetuses were NOEL = 660 mg/kg b.w. (1982) b.w. per day based on data much higher in high-dose animals.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =1000 mg/kg bw/day Rat - - Toxicology study document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=ac0cb2392535f3ae; raw_unit=mg/kg; context=In the second NOEL = 1000 mg/kg age in a second experiment experiment, rats were unaffected at 250 mg/kg b.w. b.w. per day (nature, vehicle and per day but half of the pairs did not breed in the (females) pattern of administration high-dose group.
INCHEM_WHO_ehc_ehc_ehc189 NOEL =2000 mg/kg bw/day Rat - - Developmental toxicity document_id=ehc_ehc_ehc189; title=Di-n-butyl phthalate (EHC 189, 1997); path=mirror/documents/ehc/ehc/ehc189.htm; row_hash=8e89b13d67135abb; raw_unit=mg/kg; context=Developmental effects of DBP Species Protocol Results Effect levels Reference Rat (Holtzman, Pseudopregnant rats No effect on the decidual cell response, NOEL = 2000 mg/kg Cummings & groups of 6 received 0, 250, 500, pregnant uterine weight, number of b.w. per day Gray (1987) pseudopregnant 1000 or 2000 mg/kg b.w. implantation sites, ovarian weight, or serum females and per day while pregnant progesterone concentration during e
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 4.25 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1408; Record_ID=acute_inhalation_1029; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.25; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =6300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10841; row=3984; data_type=In Vivo; mixture=Chemical; chemical_name=Dibutyl phthalate; preferred_name=Dibutyl 1,2-benzenedicarboxylate; dtxsid=DTXSID2021781; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021781; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =7499 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10842; row=3982; data_type=In Vivo; mixture=Chemical; chemical_name=Dibutyl phthalate; preferred_name=Dibutyl 1,2-benzenedicarboxylate; dtxsid=DTXSID2021781; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021781; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =8000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10843; row=3983; data_type=In Vivo; mixture=Chemical; chemical_name=Dibutyl phthalate; preferred_name=Dibutyl 1,2-benzenedicarboxylate; dtxsid=DTXSID2021781; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021781; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 42.5 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=841; Record_ID=adme_parameters_701; Data_Type=Measured; DTXSID=DTXSID2021781; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=42.5; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Tonnelier 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_adme_parameters Clint 79.3 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=842; Record_ID=adme_parameters_701; Data_Type=Measured; DTXSID=DTXSID2021781; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=79.3; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Black 2021; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_adme_parameters Fu 0.028 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=840; Record_ID=adme_parameters_701; Data_Type=Measured; DTXSID=DTXSID2021781; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.028; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Tonnelier 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_dart 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_dart LOEL 630 mg/kg bw/day Rat Oral - In Vivo; DART, Reproductive performance sheet=Data; excel_row=39454; Record_ID=dart_467; Data_Type=In Vivo; DTXSID=DTXSID2021781; Assay=DART, Reproductive performance; Endpoint=LOEL; Response=630; Response_Unit=mg/kg/day; Species=Rat; Strain=Wistar (Std:Wistar-KY); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0035150;CUI;Reproduction|UMLS;C4086749;CUI;Post-implantation Loss Percent; Reference=ToxRefDB v2 , ID = 791; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_dart LOEL 630 mg/kg bw/day Rat Oral - In Vivo; DART, Reproductive performance sheet=Data; excel_row=39455; Record_ID=dart_468; Data_Type=In Vivo; DTXSID=DTXSID2021781; Assay=DART, Reproductive performance; Endpoint=LOEL; Response=630; Response_Unit=mg/kg/day; Species=Rat; Strain=Wistar (Std:Wistar-KY); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0035150;CUI;Reproduction|UMLS;C4086649;CUI;Number of Resorptions; Reference=ToxRefDB v2 , ID = 791; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_dart LOEL 630 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=39456; Record_ID=dart_470; Data_Type=In Vivo; DTXSID=DTXSID2021781; Assay=DART, In life observation; Endpoint=LOEL; Response=630; Response_Unit=mg/kg/day; Species=Rat; Strain=Wistar (Std:Wistar-KY); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 791; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_dart LOEL 630 mg/kg bw/day Rat Oral - In Vivo; DART, Offspring survival early sheet=Data; excel_row=39457; Record_ID=dart_474; Data_Type=In Vivo; DTXSID=DTXSID2021781; Assay=DART, Offspring survival early; Endpoint=LOEL; Response=630; Response_Unit=mg/kg/day; Species=Rat; Strain=Wistar (Std:Wistar-KY); Sex=Male/Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0015954;CUI;Fetal Viability|UMLS;C4086644;CUI;Number of Live Fetuses; Reference=ToxRefDB v2 , ID = 791; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_dart LOEL 630 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=39458; Record_ID=dart_475; Data_Type=In Vivo; DTXSID=DTXSID2021781; Assay=DART, In life observation; Endpoint=LOEL; Response=630; Response_Unit=mg/kg/day; Species=Rat; Strain=Wistar (Std:Wistar-KY); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 791; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_dart LOEL 630 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=39459; Record_ID=dart_476; Data_Type=In Vivo; DTXSID=DTXSID2021781; Assay=DART, In life observation; Endpoint=LOEL; Response=630; Response_Unit=mg/kg/day; Species=Rat; Strain=Wistar (Std:Wistar-KY); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 791; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_dart LOEL 750 mg/kg bw/day Rat Oral - In Vivo; DART, Developmental malformation sheet=Data; excel_row=39460; Record_ID=dart_489; Data_Type=In Vivo; DTXSID=DTXSID2021781; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=750; Response_Unit=mg/kg/day; Species=Rat; Strain=Wistar (Std:Wistar-KY); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0226896;CUI;Oral cavity|UMLS;C0235801;CUI;Congenital anomaly of jaw; Reference=ToxRefDB v2 , ID = 791; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine 29 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 31.2458203223546 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7652; RecordID=ERPathway2016_5; DatasetName=ERPathway2016; DTXSID=DTXSID2021781; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=31.2458203223546; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 1050 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13259; Record_ID=endocrine_invitro_4102; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1050; Reported_Response_Unit=nM; Response=1050; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Shen et al. 2009; 19643168; 10.1016/j.toxlet.2009.07.019; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 27500 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=172; Record_ID=endocrine_invitro_166; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=27500; Reported_Response_Unit=nM; Response=27500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 74000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13496; Record_ID=endocrine_invitro_4163; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=74000; Reported_Response_Unit=nM; Response=74000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Christen et al. 2010; 20943248; 10.1016/j.chemosphere.2010.09.031; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 >100000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8070; Record_ID=endocrine_invitro_3507; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=100000; Reported_Response_Unit=nM; Response=100000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 128824.9552 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=76; Record_ID=endocrine_invitro_70; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=128824.9552; Reported_Response_Unit=nM; Response=128824.9552; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 190000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=174; Record_ID=endocrine_invitro_168; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=190000; Reported_Response_Unit=nM; Response=190000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 263000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=78; Record_ID=endocrine_invitro_72; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=263026.79920000001; Reported_Response_Unit=nM; Response=263000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 316227.766 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=77; Record_ID=endocrine_invitro_71; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=316227.766; Reported_Response_Unit=nM; Response=316227.766; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine AC50/EC50/IC50 820000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=173; Record_ID=endocrine_invitro_167; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=820000; Reported_Response_Unit=nM; Response=820000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine ACC 23.0625321834709 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7653; RecordID=ERPathway2016_5; DatasetName=ERPathway2016; DTXSID=DTXSID2021781; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=23.0625321834709; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine EC50 4090 nM - - - In Vitro; ER Transactivation-Agonist (VM7Luc Assay) sheet=Data_invitro; excel_row=16619; Record_ID=endocrine_invitro_4489; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=ER Transactivation-Agonist (VM7Luc Assay); Endpoint=EC50; Reported_Response=4.0899999999999998E-6; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=4089.9999999999895; Converted_Response_Unit=nM; Response=4090; Response_Unit=nM; Reference=|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine IC20 4800 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13038; Record_ID=endocrine_invitro_4039; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Reported_Response=4800; Reported_Response_Unit=IC20 (nM); Response=4800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine IC20 <10000 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13031; Record_ID=endocrine_invitro_4037; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=10000; Reported_Response_Unit=IC20 (nM); Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine LEL 100 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=14821; Record_ID=endocrine_invitro_4102; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=100; Reported_Response_Unit=nM; Response=100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Shen et al. 2009; 19643168; 10.1016/j.toxlet.2009.07.019; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine LEL 10000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10346; Record_ID=endocrine_invitro_3998; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=10000; Reported_Response_Unit=nM; Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Shen et al. 2009; 19643168; 10.1016/j.toxlet.2009.07.019; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine LOEL 500 mg/kg bw/day Rat Oral Treatment_Duration=10 days; Age_at_First_Dose=PND 50; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=8 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=6 In Vivo; Hershberger-Antagonist sheet=Data_invivo; excel_row=1502; Record_ID=endocrine_invivo_650; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=Hershberger-Antagonist; Endpoint=LOEL; Response=500; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Additional_Information=Browne et al. 2018 unique record identifier 573; Reference=Ashby and Lefevre 2000; Not available; 10.1006/rtph.1999.1372|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine LOEL 1000 mg/kg bw/day Rat Oral Treatment_Duration=10 days; Age_at_First_Dose=PND 50; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=8 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=6 In Vivo; Hershberger-Antagonist sheet=Data_invivo; excel_row=1505; Record_ID=endocrine_invivo_652; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=Hershberger-Antagonist; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Additional_Information=Browne et al. 2018 unique record identifier 576; Reference=Ashby and Lefevre 2000; Not available; 10.1006/rtph.1999.1372|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7648; RecordID=ARPathway2016_1641; DatasetName=ARPathway2016; DTXSID=DTXSID2021781; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine Model Score 0.0265 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7654; RecordID=ERPathway2016_5; DatasetName=ERPathway2016; DTXSID=DTXSID2021781; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0265; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine Model Score 0.0509 unitless - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7655; RecordID=ERPathway2016_5; DatasetName=ERPathway2016; DTXSID=DTXSID2021781; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0509; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.00024 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2448; Record_ID=endocrine_invitro_71; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=2.4000000000000001E-4; Reported_Response_Unit=Unitless; Response=0.00024; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.0004 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2614; Record_ID=endocrine_invitro_70; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=4.0000000000000002E-4; Reported_Response_Unit=Unitless; Response=4e-04; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.0005 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2617; Record_ID=endocrine_invitro_72; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=5.0000000000000001E-4; Reported_Response_Unit=Unitless; Response=5e-04; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.0017 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2629; Record_ID=endocrine_invitro_1110; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.6999999999999999E-3; Reported_Response_Unit=Unitless; Response=0.0017; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.0022 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2623; Record_ID=endocrine_invitro_167; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=2.2000000000000001E-3; Reported_Response_Unit=Unitless; Response=0.0022; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.009 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2619; Record_ID=endocrine_invitro_168; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=8.9999999999999993E-3; Reported_Response_Unit=Unitless; Response=0.009; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.0112 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2626; Record_ID=endocrine_invitro_166; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.12E-2; Reported_Response_Unit=Unitless; Response=1.12E-2; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_endocrine RBA 0.01122 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1970; Record_ID=endocrine_invitro_166; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=AR Binding; Endpoint=RBA; Reported_Response=-1.95; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=1.1220184543019634E-2; Converted_Response_Unit=Unitless; Response=0.01122; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_skin_sensitization 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CV75 1000 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1662; Record_ID=skin_sensitization_invitro_457; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_skin_sensitization Depletion Lys 0 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=222; Record_ID=skin_sensitization_invitro_68; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_skin_sensitization EC1.5 56.42 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6836; Record_ID=skin_sensitization_invitro_1618; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=56.41813797; Reported_Response_Unit=uM; Response=56.42; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_skin_sensitization IC50 500 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6838; Record_ID=skin_sensitization_invitro_1618; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=500; Reported_Response_Unit=uM; Response=500; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
NTP_ICE_skin_sensitization Imax 2.868 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6840; Record_ID=skin_sensitization_invitro_1618; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021781; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.867724574; Reported_Response_Unit=Unitless; Response=2.868; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021781; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021781
ToxRefDB_ToxRefDB_v3_pod.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxRefDB_ToxRefDB_v3_pod.csv LEL =630 mg/kg bw/day rat (wistar; Wistar (Std:Wistar-KY)) oral 7 GD to 15 GD DEV study_id=791; toxval_study_source_id=studyid791_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-postimplantation loss-postimplantation loss|reproductive performance-resorptions-resorptions; dose_level=2; study_year=1993; study_citation=Ema, M.; Amano, H.; Itami, T.; Kawasaki, H. (1993) Teratogenic evaluation of di-n-butyl phthalate in rats. Toxicology Letters 69:197-203.; dsstox_substance_id=DTXSID2021781; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =500 mg/kg bw/day rat (wistar; Wistar (Std:Wistar-KY)) oral 7 GD to 15 GD DEV study_id=791; toxval_study_source_id=studyid791_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions|reproductive performance-postimplantation loss-postimplantation loss; dose_level=1; study_year=1993; study_citation=Ema, M.; Amano, H.; Itami, T.; Kawasaki, H. (1993) Teratogenic evaluation of di-n-butyl phthalate in rats. Toxicology Letters 69:197-203.; dsstox_substance_id=DTXSID2021781; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB_ATSDR_MRLs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ATSDR_MRLs MRL =0.5 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=developmental in male/female rats; STUDY_GROUP=ATSDR MRLs:15446984:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18736f6fffe95e7d4304f137934421fb
ToxValDB_ATSDR_MRLs MRL =0.5 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=developmental in male/female rats; STUDY_GROUP=ATSDR MRLs:15446984:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18736f6fffe95e7d4304f137934421fb
ToxValDB_ATSDR_MRLs NOAEL =50 mg/kg bw/day Rat oral short-term (developmental); 10 days developmental LONG_REF=Mylchreest E, Wallace DG, Cattley RC, et al. 2000. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation. Toxicol Sci 55:143-151.; TITLE=Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation; AUTHOR=Mylchreest E; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c75; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp135.pdf; TOXICOLOGICAL_EFFECT=developmental; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ATSDR MRLs:15447492:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f7e31a0d596c7241fd6e428bdf57e81
ToxValDB_Alaska_DEC 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Alaska_DEC RfD =0.1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446184:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=8623144831a01e3906282921dec548cc
ToxValDB_Alaska_DEC RfD =0.1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446184:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=8623144831a01e3906282921dec548cc
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =56922.2 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15514254:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d68d719dbfa88f6632342d532aa4f5f2
ToxValDB_DOE_Wildlife_Benchmarks 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Wildlife_Benchmarks LOAEL =1833 mg/kg bw/day Mouse oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511612_15511613:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24a090846cffc74631422d75bb3fe66b
ToxValDB_DOE_Wildlife_Benchmarks NOAEL =550 mg/kg bw/day Mouse oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511612_15511613:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11375447e9c02a6d3da7cb934fea8b4d
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =20 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d2320fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/9/3?documentUUID=4692caa5-6145-476d-8d46-1e5181901d50; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15822789:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcc2533c5763a1eed947b53abfa0a1b9
ToxValDB_ECHA_IUCLID LOAEL =52 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba353; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/9/2?documentUUID=4692caa5-6145-476d-8d46-1e5181901d50; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15859354:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_29b0112eb20ec2415088ac1310d0ab44
ToxValDB_ECHA_IUCLID LOAEL =752 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf22e4b0a7c65d1cc9dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/6/2?documentUUID=4692caa5-6145-476d-8d46-1e5181901d50; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833440_15833441_15834971_15834972_15835538_15835539_15837908_15837909_15840029_15840030_15844134_15844135:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50ded7de749db2d4e685e88cc0e81c6f
ToxValDB_ECHA_IUCLID NOAEC >=500 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/6/3?documentUUID=5ff8a212-75d1-476f-90e3-df61187bc8ae; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827529_15828549:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0752571c78242a396a6e400ec27208b6
ToxValDB_ECHA_IUCLID NOAEC ~509 mg/m3 Rat inhalation short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fc4e4b096bca877ebdc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/6/3?documentUUID=4692caa5-6145-476d-8d46-1e5181901d50; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15827050:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2513902200cd523f3f254e5cf6005e36
ToxValDB_ECHA_IUCLID NOAEL =152 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf22e4b0a7c65d1cc9dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/6/2?documentUUID=4692caa5-6145-476d-8d46-1e5181901d50; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833440_15833441_15834971_15834972_15835538_15835539_15837908_15837909_15840029_15840030_15844134_15844135:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4a74199997dca03b018c76e199c0f0a6
ToxValDB_ECHA_IUCLID NOAEL =385 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba343; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/9/2?documentUUID=4692caa5-6145-476d-8d46-1e5181901d50; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15857046:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_58560ea1970cbcbb4ecb7ec55bb32ad0
ToxValDB_ECHA_IUCLID NOAEL =10000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d232102; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1911/7/9/3?documentUUID=4692caa5-6145-476d-8d46-1e5181901d50; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15822912:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fcabf8506aa6e60f6d8e4144df4e495
ToxValDB_ECOTOX 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =2 % diet Rat oral short-term; 7 days short-term LONG_REF=Toxicol. Appl. Pharmacol.53(1): 35-41 Oishi,S., and K. Hiraga Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations 1980; TITLE=Testicular Atrophy Induced by Phthalic Acid Esters: Effect on Testosterone and Zinc Concentrations; AUTHOR=Oishi,S., and K. Hiraga; DOI=10.1016/0041-008x(80)90378-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=66065; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Biochemistry: Zinc content|Hormone(s): Testosterone|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594747_15598244:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a8320ff3da330ca85bb0e99ac62ddab8
ToxValDB_ECOTOX LOEL =400 mg/kg bw/day European Rabbit oral subchronic; 56 days subchronic LONG_REF=Toxicol. Sci.72(2): 301-313 Higuchi,T.T., J.S. Palmer, L.E.,Jr. Gray, and D.N. Veeramachaneni Effects of Dibutyl Phthalate in Male Rabbits Following In Utero Adolescent, or Postpubertal Exposure 2003; TITLE=Effects of Dibutyl Phthalate in Male Rabbits Following In Utero Adolescent, or Postpubertal Exposure; AUTHOR=Higuchi,T.T., J.S. Palmer, L.E.,Jr. Gray, and D.N. Veeramachaneni; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=173833; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Histology: Histological changes, general|Hormone(s): Gonadotropin releasing hormone|Hormone(s): Testosterone|Morphology: Weight|Reproduction: Abnormal|Reproduction: Sperm cell counts; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|other|reproduction; STUDY_GROUP=ECOTOX:15611977:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=3c3ddbd4f37bbf23be980ef2aa824f3e
ToxValDB_ECOTOX LOEL =1000 mg/kg bw/day Rat oral short-term; 3 days short-term LONG_REF=Toxicol. Appl. Pharmacol.41(3): 609-618 Cater,B.R., M.W. Cook, S.D. Gangolli, and P. Grasso Studies on Dibutyl Phthalate-Induced Testicular Atrophy in the Rat: Effect on Zinc Metabolism 1977; TITLE=Studies on Dibutyl Phthalate-Induced Testicular Atrophy in the Rat: Effect on Zinc Metabolism; AUTHOR=Cater,B.R., M.W. Cook, S.D. Gangolli, and P. Grasso; DOI=10.1016/s0041-008x(77)80014-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=48078; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15595831:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=154dba574502cf51707610eb5eb5b110
ToxValDB_ECOTOX LOEL =3940 mg/kg bw/day Mouse oral subchronic; 90 days subchronic LONG_REF=Reprod. Toxicol.12(4): 489-494 Chapin,R.E., R.A. Sloane, and J.K. Haseman Reproductive Endpoints in General Toxicity Studies: Are they Predictive? 1998; TITLE=Reproductive Endpoints in General Toxicity Studies: Are they Predictive?; AUTHOR=Chapin,R.E., R.A. Sloane, and J.K. Haseman; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116723; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15612225:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=35d74856f73762981024ef4218131279
ToxValDB_ECOTOX LOEL =10000 ppm Mouse oral chronic; 120 days reproduction developmental LONG_REF=Reprod. Toxicol.12(4): 489-494 Chapin,R.E., R.A. Sloane, and J.K. Haseman Reproductive Endpoints in General Toxicity Studies: Are they Predictive? 1998; TITLE=Reproductive Endpoints in General Toxicity Studies: Are they Predictive?; AUTHOR=Chapin,R.E., R.A. Sloane, and J.K. Haseman; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116723; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15611727:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=fb25a19e965e7aa478c5f4ad8837d762
ToxValDB_ECOTOX NOEL =500 mg/kg bw/day Rat oral short-term; 4 days short-term LONG_REF=Toxicol. Appl. Pharmacol.41(3): 609-618 Cater,B.R., M.W. Cook, S.D. Gangolli, and P. Grasso Studies on Dibutyl Phthalate-Induced Testicular Atrophy in the Rat: Effect on Zinc Metabolism 1977; TITLE=Studies on Dibutyl Phthalate-Induced Testicular Atrophy in the Rat: Effect on Zinc Metabolism; AUTHOR=Cater,B.R., M.W. Cook, S.D. Gangolli, and P. Grasso; DOI=10.1016/s0041-008x(77)80014-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=48078; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609443_15609444_15609445:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=81069d5935f8c90845c969fbad90c8f4
ToxValDB_ECOTOX NOEL =2000 mg/kg bw/day Rat oral short-term; 10 days short-term LONG_REF=Toxicol. Appl. Pharmacol.41(3): 609-618 Cater,B.R., M.W. Cook, S.D. Gangolli, and P. Grasso Studies on Dibutyl Phthalate-Induced Testicular Atrophy in the Rat: Effect on Zinc Metabolism 1977; TITLE=Studies on Dibutyl Phthalate-Induced Testicular Atrophy in the Rat: Effect on Zinc Metabolism; AUTHOR=Cater,B.R., M.W. Cook, S.D. Gangolli, and P. Grasso; DOI=10.1016/s0041-008x(77)80014-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=48078; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604821_15604822:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5e1e304ef8d4cd4aa7e8235c72409ecc
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LOAEL =2 mg/kg bw/day Rat oral - reproduction developmental LONG_REF=EFSA AFC (2005). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Material in Contact with Food (AFC) on a request from the Commission related to Di-Butylphthalate (DBP) for use in food contact materials. doi:10.2903/j.efsa.2005.242.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Material in Contact with Food (AFC) on a request from the Commission related to Di-Butylphthalate (DBP) for use in food contact materials; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2005.242; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15614263:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3683da5327b745b5bca6bdc6594eb2a
ToxValDB_EPA_TSCA_8e 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LEL =0.031 mg/kg bw/day rodent oral - reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88020000169_84742_06B5AA4E49EF4E1C85256D5F005179EF.pdf; TOXICOLOGICAL_EFFECT=F1: reduced body weight changes; STUDY_GROUP=EPA TSCA 8e_dup_-_15957041_15957044:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_793d1d3dcf8f17658486b631cc65b6e8
ToxValDB_EPA_TSCA_8e LEL =0.063 mg/kg bw/day rodent oral - reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88020000169_84742_06B5AA4E49EF4E1C85256D5F005179EF.pdf; TOXICOLOGICAL_EFFECT=F1: low value of pituitary gland; STUDY_GROUP=EPA TSCA 8e_dup_-_15957042_15957045_15957046:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_97f73a6ca5c5c372d791cbaf87f563cc
ToxValDB_EPA_TSCA_8e LEL =0.125 mg/kg bw/day rodent oral - reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88020000169_84742_06B5AA4E49EF4E1C85256D5F005179EF.pdf; TOXICOLOGICAL_EFFECT=F1: decreased thyroid gland weight; STUDY_GROUP=EPA TSCA 8e_dup_-_15957043_15957047_15957048:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cfe3d0570b4fdf4d617688ded81d7e14
ToxValDB_EPA_TSCA_8e LEL =0.25 mg/kg bw/day rodent oral - reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88020000169_84742_06B5AA4E49EF4E1C85256D5F005179EF.pdf; TOXICOLOGICAL_EFFECT=F1: decreased survival rate, low induction of estrogen receptor alpha mRNA; STUDY_GROUP=EPA TSCA 8e_dup_-_15957041_15957044:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_884371a8bc7bc36f13f66d7f332b0c5d
ToxValDB_EPA_TSCA_8e LEL =250 mg/kg bw/day Rat oral subchronic (developmental) reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000121_84742_3023F9291A6BCF2C85256930004F3522.pdf; TOXICOLOGICAL_EFFECT=F1: decreased testicular size, poorly developed/absent epididymis; STUDY_GROUP=EPA TSCA 8e_dup_-_15957050_15957051_15957054:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6bfe665f08c10baf9476294ea8e7f5d6
ToxValDB_EPA_TSCA_8e LEL =500 mg/kg bw/day Rat oral subchronic (developmental) reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000121_84742_3023F9291A6BCF2C85256930004F3522.pdf; TOXICOLOGICAL_EFFECT=F1: decreased anogenital distance, hypospadias; STUDY_GROUP=EPA TSCA 8e_dup_-_15957050_15957051_15957054:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_98c43a670168b568d5b12d1b5f481db8
ToxValDB_EPA_TSCA_8e LEL =750 mg/kg bw/day Rat oral subchronic (developmental) reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000121_84742_3023F9291A6BCF2C85256930004F3522.pdf; TOXICOLOGICAL_EFFECT=P0: decreased number of pregnancies, decreased litter size; STUDY_GROUP=EPA TSCA 8e_dup_-_15957049_15957052_15957053:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_023ac62d2251099591ae96fa29ded63b
ToxValDB_EU_SCOEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EU_SCOEL LOAEC =1.2 mg/m3 Rat inhalation short-term; 4 weeks short-term LONG_REF=Gamer AO, Leibold E, Mellert W, Deckardt K, Kittel B, Hildebrand B (2000). Di-n-butyl phthalate - subacute inhalation study in Wistar rats. 20 exposures as a liquid aerosol. Project No. 40I0486/98063. BASF Aktiengesellschaft, Ludwigshafen, Germany.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d353b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/145_dibutylphthalate_oel_en.pdf; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=irritating of the upper respiratory tract; STUDY_GROUP=EU SCOEL:15952383:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50e3039ae48656c5234738a5ddea0676
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.13 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631051_15631052:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_01a7002b159b014d01a5209080e1287c
ToxValDB_GESTIS_DNEL DNEL systemic =4.17 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631051_15631052:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4696b9c2476769201f3fa707544682f5
ToxValDB_HAWC_Project 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HAWC_Project LOEL =500 mg/kg bw/day Rat oral short-term (developmental); 10 days developmental LONG_REF=Barlow NJ, McIntyre BS, and Foster PM. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol ; 32 (1):79-90.; TITLE=Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate.; AUTHOR=Barlow NJ, McIntyre BS, Foster PM; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/351/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/23258/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=F1: AGD (mm); TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=HAWC Project_dup_-_15636092_15636525:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9e8cd04dd6192fabaa50374b78b1459e
ToxValDB_HAWC_Project NOEL =100 mg/kg bw/day Rat oral short-term (developmental); 10 days developmental LONG_REF=Barlow NJ, McIntyre BS, and Foster PM. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol ; 32 (1):79-90.; TITLE=Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate.; AUTHOR=Barlow NJ, McIntyre BS, Foster PM; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/351/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/23258/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=F1: AGD (mm); TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=HAWC Project_dup_-_15636092_15636525:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8f41e048ff3cd304e2971f363904e905
ToxValDB_HESS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOEL =177 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e15e4b0a676289df637; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Blood chemistry: increased bile acids; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=HESS:15638996:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3c1ed27ba81fdff176baa41bcf436f08
ToxValDB_HESS NOEL <240 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e15e4b0a676289df637; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Hematology: reduced Hgb, RBC, Plt, Blood chemistry: reduced TG, Alb, Absolute organ weight: liver increase, Relative organ weight: liver increase; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=HESS:15638480:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9e40616ff1172f9a1724f76f7f77d1db
ToxValDB_Health_Canada 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Health_Canada NOEL =62.5 mg/kg bw/day Mouse oral short-term (developmental); 18 days developmental LONG_REF=PSL: HC/EC, 1994d (based on Hamano et al., 1977); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=fetotoxic and teratogenic: reduced number of live offspring, increased incidence of external defects and skeletal anomalies; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=Health Canada:15637532:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93856dcbbbee58484e93dd8462a29bf1
ToxValDB_Health_Canada TDI =0.063 mg/kg bw/day Human oral short-term (developmental); 18 days Toxicity Value LONG_REF=PSL: HC/EC, 1994d (based on Hamano et al., 1977); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=fetotoxic and teratogenic: reduced number of live offspring, increased incidence of external defects and skeletal anomalies; STUDY_GROUP=Health Canada:15637410:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_27bb3c54576fe5b5afef66fc565b4965
ToxValDB_IRIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_IRIS LOAEL =600 mg/kg bw/day Rat oral chronic; 1 years chronic LONG_REF=Smith, C.C. 1953. Toxicity of butyl sterate, dibutyl sebacate, dibutyl phthalate and methoxyethyl oleate. Arch. Hyg. Occup. Med. 7: 310-318.; TITLE=Toxicity of butyl sterate, dibutyl sebacate, dibutyl phthalate and methoxyethyl oleate; AUTHOR=Smith, C.C; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4cec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=38; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=IRIS_dup_IRIS Summary_15644071_15644072:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9e5a8ef971904502a661af0ab7fcac61
ToxValDB_IRIS NOAEL =125 mg/kg bw/day Rat oral chronic; 1 years chronic LONG_REF=Smith, C.C. 1953. Toxicity of butyl sterate, dibutyl sebacate, dibutyl phthalate and methoxyethyl oleate. Arch. Hyg. Occup. Med. 7: 310-318.; TITLE=Toxicity of butyl sterate, dibutyl sebacate, dibutyl phthalate and methoxyethyl oleate; AUTHOR=Smith, C.C; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4cec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=38; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=IRIS_dup_IRIS Summary_15644071_15644072:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cf182cac1ac26f353f6065d17df41dad
ToxValDB_MN_MDH_HHBW 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_MN_MDH_HHBW NOAEL =10 mg/kg bw/day Rat oral - repeat dose other LONG_REF=Lehmann KP, S Phillips, M Sar, PMD Foster and KW Gaido (2004). Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di(nbutyl) phthalate. Tox Sci 81: 60-68. Boekelheide K, E Kleymenova, K Liu, C Swanson and K Gaido (2009). Dose-dependent effects on cell proliferation, seminiferous tubules, and male germ cells in the fetal rat testis following exposure to di(n-butyl) phthalate. Microscopy Res Tech 72: 629-638.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4e43; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/gw/dibutylphtsumm.pdf; YEAR=2004/2009; ORIGINAL_YEAR=2004/2009; STUDY_GROUP=MN MDH HHBW:15952786:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_75715ef116317dc78d9dd0983dc504da
ToxValDB_RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfD =1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663717:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_256f7bd42afad3d3aafe03772fb54991
ToxValDB_ToxRefDB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ToxRefDB LEL =630 mg/kg bw/day Rat oral short-term (developmental); 9 days reproduction developmental LONG_REF=Ema, M.; Amano, H.; Itami, T.; Kawasaki, H. (1993) Teratogenic evaluation of di-n-butyl phthalate in rats. Toxicology Letters 69:197-203.; TITLE=Teratogenic evaluation of di-n-butyl phthalate in rats; AUTHOR=Ema, M.; Amano, H.; Itami, T.; Kawasaki, H; EXTERNAL_SOURCE_ID=791; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-postimplantation loss-postimplantation loss|reproductive: reproductive performance-resorptions-resorptions; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15682707_15682708_15682709_15682710:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f121f47547c76dd76479b41ddc801639
ToxValDB_Uterotrophic_Hershberger_DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Uterotrophic_Hershberger_DB LOEL =250 mg/kg bw/day Rat oral short-term; 10 days Hershberger LONG_REF=Ashby, J. Lefevre, P. A. (2000). "Preliminary evaluation of the major protocol variables for the Hershberger castrated male rat assay for the detection of androgens, antiandrogens, and metabolic modulators", Regulatory Toxicology and Pharmacology, 31(1) 92-105 doi: 10.1006/rtph.1999.1372; TITLE=Preliminary evaluation of the major protocol variables for the Hershberger castrated male rat assay for the detection of androgens, antiandrogens, and metabolic modulators; AUTHOR=Ashby, J. Lefevre, P. A; DOI=10.1006/rtph.1999.1372; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=active|Antiandrogenic|anti-androgenic|PPS delayed; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15714029_15714030_15714034_15714035:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c287ff004c8ded6ee7d0072fe5b464b
ToxValDB_Uterotrophic_Hershberger_DB LOEL =500 mg/kg bw/day Rat oral short-term; 10 days Hershberger LONG_REF=Ashby, J. Lefevre, P. A. (2000). "Preliminary evaluation of the major protocol variables for the Hershberger castrated male rat assay for the detection of androgens, antiandrogens, and metabolic modulators", Regulatory Toxicology and Pharmacology, 31(1) 92-105 doi: 10.1006/rtph.1999.1372; TITLE=Preliminary evaluation of the major protocol variables for the Hershberger castrated male rat assay for the detection of androgens, antiandrogens, and metabolic modulators; AUTHOR=Ashby, J. Lefevre, P. A; DOI=10.1006/rtph.1999.1372; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=active|Antiandrogenic|anti-androgenic|PPS delayed; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15714029_15714030_15714034_15714035:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c7584c196e04ff6b0350ebdcc12cd61
ToxValDB_Uterotrophic_Hershberger_DB LOEL =1000 mg/kg bw/day Rat oral short-term; 5 days Hershberger LONG_REF=Ashby, J. Lefevre, P. A. (2000). "Preliminary evaluation of the major protocol variables for the Hershberger castrated male rat assay for the detection of androgens, antiandrogens, and metabolic modulators", Regulatory Toxicology and Pharmacology, 31(1) 92-105 doi: 10.1006/rtph.1999.1372; TITLE=Preliminary evaluation of the major protocol variables for the Hershberger castrated male rat assay for the detection of androgens, antiandrogens, and metabolic modulators; AUTHOR=Ashby, J. Lefevre, P. A; DOI=10.1006/rtph.1999.1372; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40a; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=active|Antiandrogenic|anti-androgenic|PPS delayed; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15714031_15714032_15714033:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7dcaef0337990bc388194e63bc039e7
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2286E5R2KE UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H22O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2286E5R2KE"}
openFDA substances FDA UNII substance identifier 2286E5R2KE UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H22O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2286E5R2KE"}
openFDA substances FDA UNII substance identifier 2286E5R2KE UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H22O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2286E5R2KE"}
openFDA substances FDA UNII substance identifier 2286E5R2KE UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H22O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2286E5R2KE"}