Dicaffeoyl Lysyl Hexapeptide-65

INCI: DICAFFEOYL LYSYL HEXAPEPTIDE-65

CAS Number
Not assigned / not publicly available — novel peptide-polyphenol conjugate
Function
Skin conditioning (antioxidant peptide); caffeic acid conjugated to lysine-modified hexapeptide-65
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction; no CIR review available

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel ingredient with significant data gaps: no CIR review, no published HRIPT, no genotox/acute toxicity data found. Full toxicological dossier required for CPSR submission.

⚠️
Concern Level: High

Frequently Asked Questions

Is Dicaffeoyl Lysyl Hexapeptide-65 safe in cosmetics?

Novel ingredient with significant data gaps: no CIR review, no published HRIPT, no genotox/acute toxicity data found. Full toxicological dossier required for CPSR submission. The EU classifies Dicaffeoyl Lysyl Hexapeptide-65 as "permitted". Safety rating: MODERATE.

Is Dicaffeoyl Lysyl Hexapeptide-65 allowed in the EU?

Dicaffeoyl Lysyl Hexapeptide-65 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dicaffeoyl Lysyl Hexapeptide-65 do in cosmetics?

Dicaffeoyl Lysyl Hexapeptide-65 functions as: Skin conditioning (antioxidant peptide); caffeic acid conjugated to lysine-modified hexapeptide-65. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly available — novel peptide-polyphenol conjugate.

What is the Margin of Safety for Dicaffeoyl Lysyl Hexapeptide-65?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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