NOAEL Studies Cosmetic Ingredient

Dicalcium Phosphate NOAEL Studies

INCI: DICALCIUM PHOSPHATE

CAS: 7757-93-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =214 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd8e4b0a7c65d227cf8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15458/7/6/2?documentUUID=86966fd3-f7a7-41ee-b5c3-af924574788b; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=clinical signs|gross pathology|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology|mortality/survival; STUDY_GROUP=ECHA IUCLID:15844310:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38826a953f90431548846e57b8e78ba6
ToxValDB_PPRTV_(CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) NOAEL (HED) =240 mg/kg bw/day Rat oral - subchronic LONG_REF=NIER (2007) as cited in OECD (2012); NIER (2009,2010) as cited in OECD (2011a); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3bb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1674; TOXICOLOGICAL_EFFECT=No treatment - related effects; STUDY_GROUP=PPRTV (CPHEA):15654073:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c3f7b4cfd97bd5a8b15fa1f54db24a1f
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =8 mg/kg bw/day Human oral - Toxicity Value LONG_REF=NIER (2007) as cited in OECD (2012); NIER (2009,2010) as cited in OECD (2011a); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3bb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1674; TOXICOLOGICAL_EFFECT=No treatment related effects in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653872:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_180fd4290f2c2af1314be846b736dcd6
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier L11K75P92J UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.HO4P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L11K75P92J"}
openFDA substances FDA UNII substance identifier L11K75P92J UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.HO4P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L11K75P92J"}
openFDA substances FDA UNII substance identifier L11K75P92J UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.HO4P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L11K75P92J"}
openFDA substances FDA UNII substance identifier L11K75P92J UNII - - - chemical {"approval_status":null,"molecular_formula":"Ca.HO4P","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L11K75P92J"}