NOAEL Studies Cosmetic Ingredient

Dichlorobenzyl Alcohol NOAEL Studies

CAS: 1777-82-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 200 mg/kg bw/day rat oral 90 day Subchronic SCCNFP; J.E. Watson. 2,4-Dichlorobenzyl alcohol :13-Week Oral Toxicity Study in the Rat.The Boots Company. Study Report TX89028. 13 th March 1989
SCCNFP Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =100 mg/kg rat - 13 weeks NOAEL study p.7
SCCNFP Opinion NOAEL =100 mg/kg/day rabbit dermal - irritation p.8
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =100 mg/kg bw/day Rat oral subchronic; 7 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadafe4b0a7c65d1c5747; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23988/7/6/2?documentUUID=79bc58c4-20a6-4535-961e-cc9dc8513507; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15839396:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d2d3eee148b3a6bd17a73248adf00c3a
ECHA NOAEL <200 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadafe4b0a7c65d1c575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23988/7/6/2?documentUUID=79bc58c4-20a6-4535-961e-cc9dc8513507; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841644_15841645:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ecdc23b7b9b16f3994b16049283e3c2c
ECHA NOAEL =400 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadafe4b0a7c65d1c575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23988/7/6/2?documentUUID=79bc58c4-20a6-4535-961e-cc9dc8513507; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841644_15841645:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6e030cd8ef7a0b1c072bfdac011d1067
Regulatory source 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg rat - 13 weeks - p.7
Regulatory source irritation 100 mg/kg/day rabbit dermal - irritation p.8
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1NKX3648J9 UNII - - - chemical -