NOAEL Studies Cosmetic Ingredient

Dichlorophene NOAEL Studies

INCI: DICHLOROPHENE

CAS: 97-23-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =1 mg/kg/day rabbit dermal 7-day NOAEL study 72; 7; 6, p.15
CIR Safety Assessment NOAEL =25 mg/kg/day rabbit dermal 7-day NOAEL study 72; 7; 6, p.15
CIR Safety Assessment NOAEL =30 mg/kg/day rat - 2-year developmental toxicity 30; 50; 150, p.17
CIR Safety Assessment NOAEL =75 mg/kg/day rat - - developmental toxicity 100; 900; 15, 75, p.17
CIR Safety Assessment NOAEL <100 mg/kg/day rat oral - developmental toxicity 100, 300; 900; 6, p.17
CIR Safety Assessment NOAEL =120 mg/kg/day rat oral 5 days oral toxicity 11; 5; 13, p.11
CIR Safety Assessment NOAEL =240 mg/kg/day rat oral 5 days oral toxicity 5; 13; 30, 60, 120, 240, p.11
CIR Safety Assessment NOAEL >900 mg/kg/day rat oral - developmental toxicity 100, 300; 900; 6, p.17
California Proposition 65 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing ABdevelopmental listing type - - 1999-04-27 California Proposition 65 listing -
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1506 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11841; row=10074; data_type=In Vivo; mixture=Chemical; chemical_name=Dichlorophen; preferred_name=Dichlorophen; dtxsid=DTXSID6021824; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021824; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1683 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11842; row=10075; data_type=In Vivo; mixture=Chemical; chemical_name=Dichlorophen; preferred_name=Dichlorophen; dtxsid=DTXSID6021824; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021824; source_file=acute_oral.xlsx
NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 13.2 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2379; Record_ID=adme_parameters_969; Data_Type=Measured; DTXSID=DTXSID6021824; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=13.2; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE adme parameters Fu 0.0045 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2378; Record_ID=adme_parameters_969; Data_Type=Measured; DTXSID=DTXSID6021824; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0045; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 15.48201604 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7746; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=15.48201604; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine AC50 17.199492691799 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7752; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=17.199492691799; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine ACC 14.8521862953658 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7753; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=14.8521862953658; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine ACC 16.0241547366554 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7747; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=16.0241547366554; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7749; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine Model Score 0.0058 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=7754; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0058; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine Model Score 0.0643 unitless - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7755; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0643; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE endocrine Model Score 0.337 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=7748; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.337; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 37.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11440; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=37.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 110 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11463; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=110; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Concentration, one positive response 5 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11436; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Concentration, one positive response 20 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11459; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=20; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11448; Record_ID=skin_sensitization_invivo_2487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Incidence of positive responses 0.6667 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11433; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.6667; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Incidence of positive responses 0.9091 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11456; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.9091; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Induction dose per skin area 3488 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11446; Record_ID=skin_sensitization_invivo_2487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3488; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Induction dose per skin area 5625 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11431; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=5625; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Induction dose per skin area 13950 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11454; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=13950; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 42187.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11442; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=42187.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 76730 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11465; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=76730; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=11444; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824
Regulatory source 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 1 mg/kg/day rabbit dermal 7-day - p.15
Regulatory source - 25 mg/kg/day rabbit dermal 7-day - p.15
Regulatory source developmental toxicity 30 mg/kg/day rat - 2-year developmental toxicity p.17
Regulatory source developmental toxicity 75 mg/kg/day rat - - developmental toxicity p.17
Regulatory source developmental toxicity 75 mg/kg/day rat dermal - developmental toxicity p.24
Regulatory source developmental toxicity <100 mg/kg/day rat oral - developmental toxicity p.17
Regulatory source developmental toxicity >100 mg/kg/day rat - 2-year developmental toxicity p.17
Regulatory source developmental toxicity >900 mg/kg/day rat oral - developmental toxicity p.17
Regulatory source oral toxicity 120 mg/kg/day rat oral 5 days oral toxicity p.11
Regulatory source oral toxicity 240 mg/kg/day rat oral 5 days oral toxicity p.11
Regulatory source repeated dose toxicity 120 mg/kg/day rat - subchronic repeated dose toxicity p.24
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier T1J0JOU64O UNII - - - chemical -