NOAEL Studies
Cosmetic Ingredient
DIETHANOLAMINE NOAEL Studies
CAS: 111-42-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =1.5 | mg/m3 | rat | inhalation | 3 months | repeated dose toxicity | 0, 1; 5, 3; 8, p.13 |
| CIR Safety Assessment | NOAEL | =10 | mg/kg/d | mouse | dermal | 4 weeks | NOAEL study | 74; 4; 10, p.17 |
| CIR Safety Assessment | NOAEL | =35 | mg/kg/d | mouse | oral | - | developmental toxicity | 15; 35, 100; 350, p.13 |
| CIR Safety Assessment | NOAEL | =50 | mg/kg/d | rat | oral | - | developmental toxicity | 0; 3; 50, 200, 500, 800, p.13 |
| CIR Safety Assessment | NOAEL | =200 | mg/kg/ d | rat | oral | - | developmental toxicity | (20; 320; 1,500, p.18 |
| CIR Safety Assessment | NOAEL | =250 | mg/kg | rat | - | 5 d | NOAEL study | 250; 500; 99, p.11 |
| CIR Safety Assessment | NOAEL | =250 | mg/kg d | rat | oral | 7 weeks | oral toxicity | 125; 500; (7, p.11 |
| CIR Safety Assessment | NOAEL | =350 | mg/kg/d | mouse | oral | - | developmental toxicity | 6; 18; 2, p.13 |
| CIR Safety Assessment | NOAEL | =380 | mg/kg/d | rabbit | dermal | - | developmental toxicity | 150, 500; 1,500; 6, p.13 |
California Proposition 65 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 2012-06-22 | California Proposition 65 listing | - |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | - |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =210 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1034; row=5552; data_type=In Vivo; mixture=Chemical; chemical_name=Diethanolamine; preferred_name=Diethanolamine; dtxsid=DTXSID3021932; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021932; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =710 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1035; row=5551; data_type=In Vivo; mixture=Chemical; chemical_name=Diethanolamine; preferred_name=Diethanolamine; dtxsid=DTXSID3021932; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021932; source_file=acute_oral.xlsx |
NTP ICE cancer 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=3744; Record_ID=cancer_5703; Data_Type=WOE; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/95; http://publications.iarc.fr/125; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE cancer | POLY-3 lowest dose | 40 | mg/kg bw/day | Mouse | Dermal | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3735; Record_ID=cancer_5699; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=40; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Level_of_Evidence=Clear evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma, hepatocellular adenoma, or hepatoblastoma; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE cancer | POLY-3 lowest dose | 160 | mg/kg bw/day | Mouse | Dermal | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3736; Record_ID=cancer_5699; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=160; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Level_of_Evidence=Clear evidence; Tissue=Kidney; Location=Renal tubule; Lesion=Adenoma; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE cancer | Top dose | 32 | mg/kg | Rat | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3747; Record_ID=cancer_5705; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=32; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Female; Route=Dermal; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE cancer | Top dose | 64 | mg/kg | Rat | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3738; Record_ID=cancer_5698; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=64; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Dermal; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE cancer | Top dose | 160 | mg/kg | Mouse | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3737; Record_ID=cancer_5699; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=160; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
NTP ICE dart 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 15 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Hematology | sheet=Data; excel_row=49725; Record_ID=dart_23877; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Hematology; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0018935;CUI;Hematocrit procedure|UMLS;C0018941;CUI;Hematologic Tests; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE dart | LOEL | 100 | mg/kg bw/day | Rabbit | Dermal | - | In Vivo; DART, In life observation | sheet=Data; excel_row=49734; Record_ID=dart_24082; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5325; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE dart | LOEL | 1500 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=49728; Record_ID=dart_24045; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7910; RecordID=ARPathway2016_567; DatasetName=ARPathway2016; DTXSID=DTXSID3021932; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
NTP ICE skin sensitization 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 1281 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2342; Record_ID=skin_sensitization_invitro_572; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=1280.9000000000001; Reported_Response_Unit=ug/mL; Response=1281; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE skin sensitization | CD86, EC150 | 26.89 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8668; Record_ID=skin_sensitization_invitro_2399; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=26.89; Reported_Response_Unit=ug/mL; Response=26.89; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE skin sensitization | CD86, EC150 | 1242.5 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2341; Record_ID=skin_sensitization_invitro_572; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=1242.5; Reported_Response_Unit=ug/mL; Response=1242.5; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE skin sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8667; Record_ID=skin_sensitization_invitro_2399; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE skin sensitization | CV75 | 2277 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2343; Record_ID=skin_sensitization_invitro_572; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=h-CLAT; Endpoint=CV75; Reported_Response=2277; Reported_Response_Unit=ug/mL; Response=2277; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4750; Record_ID=skin_sensitization_invitro_1098; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP ICE skin sensitization | Imax | 1 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4756; Record_ID=skin_sensitization_invitro_1098; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1; Reported_Response_Unit=Unitless; Response=1; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
EPA ToxRefDB v3 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =8 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5327; toxval_study_source_id=studyid5327_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-exudate|pathology microscopic-skin-hyperkeratosis|pathology microscopic-kidney-nephropathy|pathology microscopic-skin-acanthosis|in life observation-clinical signs-skin ulceration|in life observation-body weight-body weight; dose_level=1; study_year=1999; study_citation=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =14 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5314; toxval_study_source_id=studyid5314_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-mineralization|organ weight-kidney-absolute|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-bile acids-bile acids|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|organ weight-liver-relative to body weight|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|hematology-reticulocyte-reticulocyte|hematology-hematocrit (hct)-hematocrit (hct)|organ weight-liver-absolute|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-adrenal gland-vacuolization cytoplasmic|in life observation-clinical signs-tremors|pathology microscopic-brain-demyelination|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-emaciation|in life observation-clinical signs-abnormal posture|pathology microscopic-spinal cord-demyelination|pathology microscopic-kidney-necrosis|in life observation-water consumption-water consumption; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =16 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5327; toxval_study_source_id=studyid5327_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|pathology microscopic-skin-exudate|pathology microscopic-skin-hyperkeratosis|in life observation-clinical signs-skin ulceration|in life observation-body weight-body weight; dose_level=2; study_year=1999; study_citation=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =25 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5314; toxval_study_source_id=studyid5314_Adult_F0_M_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-kidney-relative to body weight|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|organ weight-epididymis-relative to body weight|in life observation-water consumption-water consumption|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight|clinical chemistry-bile acids-bile acids|organ weight-liver-relative to body weight|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-epididymis-hypospermia|pathology microscopic-epididymis-degeneration|organ weight-epididymis-absolute|pathology microscopic-testes-reduced spermatogenesis|pathology gross-testes-reduced size|organ weight-testes-absolute|pathology microscopic-kidney-mineralization|pathology microscopic-brain-demyelination|pathology microscopic-prostate-atrophy|in life observation-clinical signs-abnormal posture|organ weight-testes-relative to body weight|in life observation-clinical signs-fur (altered appearance)|pathology microscopic-seminal vesicle-atrophy|pathology gross-sperm measure-sperm count|pathology microscopic-spinal cord-demyelination|pathology microscopic-testes-degeneration|pathology gross-sperm measure-sperm motility|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-emaciation|pathology microscopic-epididymis-congestion|in life observation-clinical signs-tremors|pathology microscopic-kidney-necrosis|pathology microscopic-kidney-nephropathy|pathology microscopic-adrenal gland-vacuolization cytoplasmic|in life observation-mortality-mortality; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =32 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 13 week | SUB | study_id=5320; toxval_study_source_id=studyid5320_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-hyperkeratosis|organ weight-kidney-relative to body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-liver-absolute|pathology microscopic-kidney-nephropathy|organ weight-kidney-absolute|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-liver-relative to body weight|hematology-reticulocyte-reticulocyte|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-kidney-mineralization|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-skin-acanthosis|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-skin-inflammation|in life observation-clinical signs-scabbing|in life observation-body weight-body weight|pathology microscopic-skin-ulcer|pathology microscopic-kidney-necrosis|pathology microscopic-brain-demyelination|in life observation-mortality-mortality; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_13 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =40 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5329; toxval_study_source_id=studyid5329_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-thyroid gland-hyperplasia|pathology microscopic-liver-hepatocellular adenoma|pathology microscopic-liver-syncytial alteration|in life observation-mortality-mortality|pathology microscopic-liver-hepatocellular carcinoma|pathology microscopic-skin-hyperkeratosis|pathology microscopic-skin-exudate; dose_level=1; study_year=1999; study_citation=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =77 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-kidney-relative to body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|organ weight-kidney-absolute|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-reticulocyte-reticulocyte|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|urinalysis-[other]-[other]|in life observation-body weight-body weight gain|pathology gross-testes-reduced size|urinalysis-protein-protein|pathology microscopic-kidney-necrosis|pathology microscopic-epididymis-cellular alteration|in life observation-clinical signs-reduced activity|in life observation-mortality-mortality|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-tremors|urinalysis-glucose-glucose|pathology microscopic-testes-degeneration|pathology microscopic-epididymis-oligospermia; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =79 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=hematology-reticulocyte-reticulocyte|organ weight-kidney-absolute|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-kidney-relative to body weight|in life observation-water consumption-water consumption|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight gain|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|urinalysis-[other]-[other]|pathology microscopic-kidney-necrosis|urinalysis-glucose-glucose|urinalysis-protein-protein|in life observation-mortality-mortality|in life observation-clinical signs-reduced activity|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-tremors; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =80 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 13 week | SUB | study_id=5322; toxval_study_source_id=studyid5322_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-skin-acanthosis|pathology microscopic-liver-cytologic alterations|pathology microscopic-skin-inflammation|in life observation-clinical signs-scabbing|pathology gross-skin-thickened|pathology microscopic-skin-ulcer|organ weight-kidney-relative to body weight|organ weight-heart-absolute|organ weight-heart-relative to body weight|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-mortality-mortality|pathology microscopic-kidney-necrosis|pathology microscopic-skin-hyperkeratosis|pathology microscopic-heart-degeneration|pathology microscopic-salivary glands-cellular alteration; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_13 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =104 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5316; toxval_study_source_id=studyid5316_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|organ weight-liver-absolute|pathology microscopic-liver-cytologic alterations|organ weight-liver-relative to body weight|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|in life observation-body weight-body weight gain|in life observation-clinical signs-tremors|organ weight-heart-relative to body weight|pathology microscopic-salivary glands-[other]|pathology microscopic-liver-necrosis|in life observation-clinical signs-emaciation|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|in life observation-clinical signs-reduced activity|pathology microscopic-heart-degeneration|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-abnormal posture|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-mortality-mortality|pathology microscopic-kidney-necrosis; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =125 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 14 day | SAC | study_id=5317; toxval_study_source_id=studyid5317_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-hyperplasia|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-skin-acanthosis|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-skin-inflammation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-skin-ulcer|in life observation-clinical signs-emaciation|in life observation-mortality-mortality|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|in life observation-clinical signs-respiration (dyspnea)|pathology microscopic-kidney-necrosis|in life observation-clinical signs-scabbing|urinalysis-[other]-[other]|in life observation-body weight-body weight gain|in life observation-clinical signs-reduced activity; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =142 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5316; toxval_study_source_id=studyid5316_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|pathology microscopic-liver-cytologic alterations|organ weight-liver-relative to body weight|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|organ weight-kidney-relative to body weight|pathology microscopic-liver-necrosis|in life observation-body weight-body weight gain|organ weight-heart-relative to body weight|in life observation-clinical signs-tremors|in life observation-clinical signs-fur (altered appearance)|organ weight-heart-absolute|pathology microscopic-heart-degeneration|pathology microscopic-salivary glands-[other]|in life observation-mortality-mortality|in life observation-clinical signs-emaciation|pathology microscopic-kidney-nephropathy|in life observation-clinical signs-reduced activity|in life observation-clinical signs-abnormal posture|pathology microscopic-kidney-necrosis; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =160 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 14 day | SAC | study_id=5319; toxval_study_source_id=studyid5319_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|organ weight-liver-relative to body weight|organ weight-liver-absolute|pathology microscopic-liver-cytologic alterations|in life observation-mortality-mortality|in life observation-clinical signs-skin ulceration|pathology microscopic-skin-inflammation|pathology microscopic-skin-ulcer|in life observation-clinical signs-scabbing; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =205 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-heart-degeneration|in life observation-clinical signs-emaciation|in life observation-water consumption-water consumption|in life observation-clinical signs-fur (altered appearance)|in life observation-body weight-body weight|in life observation-clinical signs-abnormal posture; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =326 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-liver-cytologic alterations|in life observation-body weight-body weight|pathology microscopic-heart-degeneration|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-fur (altered appearance)|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|in life observation-clinical signs-emaciation|in life observation-water consumption-water consumption; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =319 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-kidney-absolute|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh); dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =371 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=urinalysis-[other]-[other]|pathology microscopic-kidney-necrosis|organ weight-kidney-relative to body weight|urinalysis-glucose-glucose|urinalysis-protein-protein|in life observation-body weight-body weight gain|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|organ weight-kidney-absolute; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =415 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =793 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1000 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 14 day | SAC | study_id=5317; toxval_study_source_id=studyid5317_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-emaciation|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|in life observation-clinical signs-respiration (dyspnea)|pathology microscopic-kidney-necrosis|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|urinalysis-[other]-[other]|in life observation-body weight-body weight gain|in life observation-clinical signs-reduced activity; dose_level=4; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1250 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 14 day | SAC | study_id=5319; toxval_study_source_id=studyid5319_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis; dose_level=4; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=urinalysis-[other]-[other]|pathology microscopic-kidney-necrosis|in life observation-water consumption-water consumption|in life observation-clinical signs-abnormal posture|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-kidney-relative to body weight|in life observation-mortality-mortality|in life observation-clinical signs-reduced activity|urinalysis-glucose-glucose|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-body weight-body weight gain|urinalysis-protein-protein|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-tremors|organ weight-kidney-absolute; dose_level=0; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =110 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|in life observation-water consumption-water consumption|in life observation-body weight-body weight|in life observation-clinical signs-fur (altered appearance)|organ weight-liver-absolute|in life observation-clinical signs-emaciation|pathology microscopic-heart-degeneration|organ weight-liver-relative to body weight|in life observation-clinical signs-abnormal posture; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =197 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|organ weight-liver-relative to body weight|organ weight-liver-absolute|pathology microscopic-heart-degeneration|in life observation-body weight-body weight|in life observation-clinical signs-abnormal posture|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-emaciation|in life observation-water consumption-water consumption; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =158 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-kidney-relative to body weight|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-clinical signs-abnormal posture|urinalysis-[other]-[other]|in life observation-water consumption-water consumption|pathology microscopic-kidney-necrosis|hematology-hemoglobin (hgb)-hemoglobin (hgb)|urinalysis-glucose-glucose|in life observation-clinical signs-reduced activity|in life observation-mortality-mortality|urinalysis-protein-protein|in life observation-body weight-body weight gain|organ weight-kidney-absolute|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-tremors|hematology-hematocrit (hct)-hematocrit (hct)|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh); dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =162 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-kidney-necrosis|in life observation-clinical signs-reduced activity|hematology-reticulocyte-reticulocyte|pathology microscopic-epididymis-cellular alteration|organ weight-kidney-relative to body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|urinalysis-protein-protein|urinalysis-[other]-[other]|in life observation-water consumption-water consumption|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology gross-testes-reduced size|pathology microscopic-testes-degeneration|pathology microscopic-epididymis-oligospermia|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hematocrit (hct)-hematocrit (hct)|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|urinalysis-glucose-glucose|in life observation-clinical signs-tremors|organ weight-kidney-absolute|in life observation-mortality-mortality|in life observation-clinical signs-abnormal posture; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =500 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 14 day | SAC | study_id=5317; toxval_study_source_id=studyid5317_Adult_F0_F_systemic; toxval_effect_list=urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-skin-inflammation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-clinical signs-emaciation|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-mortality-mortality|urinalysis-[other]-[other]|pathology microscopic-skin-hyperplasia|in life observation-body weight-body weight gain|in life observation-clinical signs-reduced activity|pathology microscopic-skin-ulcer|hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|in life observation-clinical signs-respiration (dyspnea)|in life observation-clinical signs-scabbing|pathology microscopic-kidney-necrosis|pathology microscopic-skin-acanthosis; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =630 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 14 day | SAC | study_id=5319; toxval_study_source_id=studyid5319_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|pathology microscopic-skin-ulcer|in life observation-clinical signs-scabbing|organ weight-liver-relative to body weight|in life observation-clinical signs-skin ulceration|pathology microscopic-skin-inflammation|pathology microscopic-skin-acanthosis|organ weight-liver-absolute|in life observation-mortality-mortality; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB Cal OEHHA REL derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | LOAEL | =15 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=Gamer AO, Hellwig J, and Hildebrand B. 1993. Study of the prenatal toxicity of diethanolamin in rats after inhalation. BASF Project No. 31RO233/90010. Ludwigshafen, FRG: BASF; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Chronic inflammation and squamous hyperplasia and metaplasia of the larynx; STUDY_GROUP=Cal OEHHA REL derivations:15952040:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_930e2caff1314a189d213b21a35ffaed |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =68801.7 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15514449:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_117e883898a6346e646070bd9ba72cf0 |
ToxValDB EPA TSCA 8e 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =32 | mg/kg bw/day | Rat | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=reduced weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EPA TSCA 8e:15957062:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5da827e988348456c5b607f3417b2b8e |
| ToxValDB EPA TSCA 8e | LEL | =40 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=decreased body weight, decreased survival, increased incidence of hepatocellular adenoma, increased incidence of hepatocellular carcinoma, increased incidence of hepatoblastoma, increased incidence of renal tubule adenoma; STUDY_GROUP=EPA TSCA 8e:15957064:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d43698dbd6f8c9c25dc4cfab25fbb02 |
| ToxValDB EPA TSCA 8e | LEL | =80 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=decreased body weight, decreased survival; STUDY_GROUP=EPA TSCA 8e_dup_-_15957065_15957066:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_428008437f804e1ebb46404479ca74ee |
| ToxValDB EPA TSCA 8e | LEL | =100 | ppm | Rat | oral | - | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20984_Combined.pdf; TOXICOLOGICAL_EFFECT=F1: decreased thyroid hormone levels; STUDY_GROUP=EPA TSCA 8e_dup_-_15957170_15957171_15957172:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3add770b403d25ba13fbfcf81f44b176 |
| ToxValDB EPA TSCA 8e | LEL | =300 | ppm | Rat | oral | - | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20984_Combined.pdf; TOXICOLOGICAL_EFFECT=P0: systemic toxicity, neurological toxicity; STUDY_GROUP=EPA TSCA 8e_dup_-_15957170_15957171_15957172:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6abc2aee4ac7feada31d461995f51f49 |
| ToxValDB EPA TSCA 8e | NEL | =34 | mg/kg bw/day | Rat | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=no effects on survival; STUDY_GROUP=EPA TSCA 8e:15957063:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6bba3683f458828733c3ce1157ede54e |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632779_15632780:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02b84a2ca155d8ccd68051525dae6c7d |
| ToxValDB GESTIS DNEL | DNEL systemic | =0.75 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632779_15632780:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e5b463fcd0df8f8a799eff9766760c6 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | <24.32 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e16e4b0a676289df6db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Tremors Emaciation Abnormal posture Rough fur|Body Weight Changes: decrease|Water Consumption: decrease|Urinalysis: TP increase, LDH increasep H increase|Hematology: MCV decrease, MCH decrease, Hct decrease, Hgb decrease, RBC decrease, MCHC increase, Ret decrease, WBC decrease, Seg decrease, Lymph decrease|Blood Chemistry: TP increase, Bile acid increase, Alb increase, BUN increase|Absolute Organ Weight: Rightkidney increase, Liver increase, Right testis decrease, Epididymis decrease|Relative Organ Weight: Rightkidney increase, Liver increase, Right testis decrease, Epididymis decrease|Histopathology: Rightkidney-Nephropathy Rightkidney-Tubular epithelial necrosis Rightkidney-Tubular mineralization Brain, medulla-Demyelination Spinal cord-Demyelination Epididymis-Seminiferous epithelium degeneration Testicular-degenerationadrenal cortex-Cytoplasmic vacuolization|Reproductive Tissue Evaluation: Spermatozoal measurements-Motility decrease, Spermatozoal measurements-Concentration decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction|urinalysis; STUDY_GROUP=HESS:15638485:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c6eb3968e40c4cd90be9719c735c9fc0 |
ToxValDB PPRTV (CPHEA) 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | BMCL (10 HEC) | =0.63 | mg/m3 | Rat | inhalation | chronic; 99 days | chronic | LONG_REF=Gamer et al. 2008c; AUTHOR=Gamer et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=increased incidence of squamous metaplasia (level 1) (males); STUDY_GROUP=PPRTV (CPHEA):15653532:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bac2de5e03a44a5d8825ab2af710d982 |
| ToxValDB PPRTV (CPHEA) | BMDL (1SD) | =6.85 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP 1992a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=reduced relative kidney weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=PPRTV (CPHEA):15653860:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b8e0ad60d8eaa13ad00d467446fbd48b |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.002 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Gamer et al. 2008c; AUTHOR=Gamer et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=Increase incidence of squamous metaplasia (level 1) in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653530_15653531:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_afdc1399f38c39d3a8d090df7602f92b |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=NTP 1992a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=Significant reduction in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653339_15653486:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_457d666335813f0543011f0f7a5a8094 |
ToxValDB Pennsylvania DEP ToxValues 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfC | =0.0002 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650053:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c521e349fc7cc1ff38fce1227eff679 |
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.002 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650052:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3512f298bb3d66eb7a5d86f9d524096e |
ToxValDB TX TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | BMDL (10 HEC) | =12.9 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=Gamer, A.O., Rossbacher, R., Kaufmann, W. and van Ravenzwaay, B. 2008. The inhalation toxicity of di- and triethanolamine upon repeated exposure. Food and Chemical Toxicology. 46: 2173-2183; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b1b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/dea-tea.pdf; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=Increased relative liver weight in female rats.; STUDY_GROUP=TX TCEQ:15954406:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b833d5936cd82ce9a0439a2edef9b908 |
ToxValDB ToxRefDB 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =8 | mg/kg bw/day | Rat | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; TITLE=Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5327; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-skin-exudate|systemic: pathology microscopic-skin-hyperkeratosis|systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-skin ulceration|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708975_15708976:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6717b86a6da715ae92e6d134f5852a40 |
| ToxValDB ToxRefDB | LEL | =14 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5314; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-mineralization|systemic: organ weight-kidney-absolute|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-kidney-nephropathy|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-bile acids-bile acids|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: organ weight-kidney-relative to body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-spinal cord-demyelination|systemic: pathology microscopic-adrenal gland-vacuolization cytoplasmic|systemic: pathology microscopic-kidney-necrosis|systemic: in life observation-clinical signs-tremors|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-brain-demyelination|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708949_15708950:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3bdf49e1807f9704c638f386898d5b02 |
| ToxValDB ToxRefDB | LEL | =16 | mg/kg bw/day | Rat | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; TITLE=Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5327; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-hyperkeratosis|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-exudate|systemic: in life observation-clinical signs-skin ulceration|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708977_15708978:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_841efae1430af89999a667b045f02828 |
| ToxValDB ToxRefDB | LEL | =25 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5314; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: organ weight-kidney-relative to body weight|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: organ weight-epididymis-relative to body weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-water consumption-water consumption|systemic: clinical chemistry-bile acids-bile acids|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology microscopic-kidney-mineralization|systemic: pathology gross-testes-reduced size|systemic: organ weight-testes-absolute|systemic: pathology microscopic-epididymis-hypospermia|systemic: pathology microscopic-epididymis-degeneration|systemic: organ weight-epididymis-absolute|systemic: pathology microscopic-testes-reduced spermatogenesis|systemic: pathology microscopic-brain-demyelination|systemic: pathology microscopic-prostate-atrophy|systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-clinical signs-emaciation|systemic: pathology gross-sperm measure-sperm count|systemic: in life observation-clinical signs-abnormal posture|systemic: pathology microscopic-spinal cord-demyelination|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-seminal vesicle-atrophy|systemic: pathology microscopic-testes-degeneration|systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-epididymis-congestion|systemic: in life observation-clinical signs-tremors|systemic: organ weight-testes-relative to body weight|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-adrenal gland-vacuolization cytoplasmic|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB:15708951:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d03c21d34f5d95a9a92be0a7aa98c42 |
| ToxValDB ToxRefDB | LEL | =32 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5320; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-hyperkeratosis|systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-liver-absolute|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-kidney-nephropathy|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-kidney-mineralization|systemic: organ weight-liver-relative to body weight|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: organ weight-kidney-absolute|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-scabbing|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-skin-ulcer|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-brain-demyelination|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708968_15708969:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b698e6b9b7ca8d6694dc1870e204ee0d |
| ToxValDB ToxRefDB | LEL | =77 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-reticulocyte-reticulocyte|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-[other]-[other]|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-tremors|systemic: urinalysis-glucose-glucose|systemic: urinalysis-protein-protein|systemic: pathology gross-testes-reduced size|systemic: pathology microscopic-testes-degeneration|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-epididymis-cellular alteration|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-reduced activity|systemic: pathology microscopic-epididymis-oligospermia|systemic: in life observation-clinical signs-abnormal posture; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708938_15708939_15708940:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7736f9e1a60df28c45b45d1659602eb0 |
| ToxValDB ToxRefDB | LEL | =79 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-water consumption-water consumption|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-body weight-body weight gain|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-protein-protein|systemic: urinalysis-[other]-[other]|systemic: pathology microscopic-kidney-necrosis|systemic: urinalysis-glucose-glucose|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-tremors|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-reduced activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708935_15708936_15708937:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93892f9bf462c35d558035dd05e3e9c1 |
| ToxValDB ToxRefDB | LEL | =80 | mg/kg bw/day | Mouse | dermal | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5322; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytologic alterations|systemic: pathology microscopic-skin-inflammation|systemic: pathology gross-skin-thickened|systemic: pathology microscopic-skin-ulcer|systemic: in life observation-clinical signs-scabbing|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-heart-absolute|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-salivary glands-cellular alteration|systemic: organ weight-heart-relative to body weight|systemic: pathology microscopic-skin-hyperkeratosis|systemic: pathology microscopic-heart-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB:15708972:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a921380225503c8160817bd2a5608509 |
| ToxValDB ToxRefDB | LEL | =104 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5316; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-salivary glands-[other]|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-reduced activity|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: in life observation-clinical signs-tremors|systemic: organ weight-heart-relative to body weight|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708954_15708955:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a52c30df9849731414b36cde7231092 |
| ToxValDB ToxRefDB | LEL | =125 | mg/kg bw/day | Rat | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5317; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: pathology microscopic-skin-hyperplasia|systemic: organ weight-kidney-relative to body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-skin-acanthosis|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-skin-ulcer|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-clinical signs-respiration (dyspnea)|systemic: pathology microscopic-kidney-necrosis|systemic: in life observation-clinical signs-scabbing|systemic: urinalysis-[other]-[other]|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708956_15708957_15708958:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b9d49a6f12b0ae43279c3b35014de56 |
| ToxValDB ToxRefDB | LEL | =142 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5316; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-body weight-body weight gain|systemic: organ weight-heart-relative to body weight|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-kidney-nephropathy|systemic: organ weight-heart-absolute|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-clinical signs-tremors|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-heart-degeneration|systemic: pathology microscopic-salivary glands-[other]|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708952_15708953:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e770e626a0480fbdba057c4573666938 |
| ToxValDB ToxRefDB | LEL | =160 | mg/kg bw/day | Mouse | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5319; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-clinical signs-skin ulceration|systemic: pathology microscopic-liver-cytologic alterations|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-skin-ulcer|systemic: in life observation-clinical signs-scabbing; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708962_15708963_15708964:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d3f828f6afb19dd284bbaa6abee5bcf |
| ToxValDB ToxRefDB | LEL | =205 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708945_15708946_15708947_15708948:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af46555bc95f8a7a9dcd77de7d95df62 |
| ToxValDB ToxRefDB | LEL | =326 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-cytologic alterations|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708941_15708942_15708943_15708944:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a3906400a6c8974a0a944462e17461f |
| ToxValDB ToxRefDB | LOAEL | =319 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh); TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708938_15708939_15708940:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3fb1eb17086b171b549475e3354bedd8 |
| ToxValDB ToxRefDB | LOAEL | =371 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: urinalysis-protein-protein|systemic: urinalysis-[other]-[other]|systemic: in life observation-body weight-body weight gain|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: pathology microscopic-kidney-necrosis|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: urinalysis-glucose-glucose; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708935_15708936_15708937:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06754d6fdc858edadf05aa58840c7eee |
| ToxValDB ToxRefDB | LOAEL | =415 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytologic alterations; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708945_15708946_15708947_15708948:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a965555c557d793985cce7ac079ddb48 |
| ToxValDB ToxRefDB | LOAEL | =793 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708941_15708942_15708943_15708944:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_30287f8b0901f7468cc3f1ffeb29f93d |
| ToxValDB ToxRefDB | LOAEL | =1000 | mg/kg bw/day | Rat | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5317; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-respiration (dyspnea)|systemic: pathology microscopic-kidney-necrosis|systemic: organ weight-kidney-absolute|systemic: urinalysis-[other]-[other]|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-reduced activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708956_15708957_15708958:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_81eb0bef0963607329cc2513480ef45c |
| ToxValDB ToxRefDB | LOAEL | =1250 | mg/kg bw/day | Mouse | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5319; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis; STUDY_GROUP=ToxRefDB_dup_-_15708962_15708963_15708964:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59626ba07eb4c67afe185e7f52f86fc5 |
| ToxValDB ToxRefDB | NEL | =110 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-cytologic alterations|systemic: in life observation-water consumption-water consumption|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-fur (altered appearance); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708945_15708946_15708947_15708948:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_560cba5881c56fc4a4b5a9160b11213b |
| ToxValDB ToxRefDB | NEL | =197 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: pathology microscopic-liver-cytologic alterations|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-abnormal posture|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708941_15708942_15708943_15708944:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0ae7074d3652e8a15250b8c24ff7dd1 |
| ToxValDB ToxRefDB | NOAEL | =158 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: organ weight-kidney-relative to body weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-clinical signs-tremors|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-clinical signs-abnormal posture|systemic: urinalysis-glucose-glucose|systemic: in life observation-clinical signs-reduced activity|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: urinalysis-protein-protein|systemic: in life observation-body weight-body weight gain|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-[other]-[other]|systemic: in life observation-water consumption-water consumption|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708935_15708936_15708937:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_84c4467504e7ab1aced7f9efb5c60f42 |
| ToxValDB ToxRefDB | NOAEL | =162 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-necrosis|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-testes-degeneration|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-reduced activity|systemic: hematology-reticulocyte-reticulocyte|systemic: pathology microscopic-epididymis-cellular alteration|systemic: in life observation-water consumption-water consumption|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-epididymis-oligospermia|systemic: in life observation-clinical signs-abnormal posture|systemic: organ weight-kidney-relative to body weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-glucose-glucose|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: urinalysis-protein-protein|systemic: pathology gross-testes-reduced size|systemic: in life observation-clinical signs-tremors|systemic: urinalysis-[other]-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708938_15708939_15708940:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec43e730ce757f110b6d87a68f7d79b7 |
| ToxValDB ToxRefDB | NOAEL | =500 | mg/kg bw/day | Rat | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5317; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: urinalysis-[other]-[other]|systemic: pathology microscopic-skin-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-clinical signs-emaciation|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-clinical signs-reduced activity|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology microscopic-skin-ulcer|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-respiration (dyspnea)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-clinical signs-scabbing|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-skin-acanthosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708956_15708957_15708958:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c4dc5d2527eb6e0b12db4c3470f9010 |
| ToxValDB ToxRefDB | NOAEL | =630 | mg/kg bw/day | Mouse | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5319; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-ulcer|systemic: in life observation-clinical signs-scabbing|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-skin ulceration|systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-absolute|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708962_15708963_15708964:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09f942c67ec8e6041d7958c861c2b28a |
Regulatory source 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 10 | mg/kg/d | mouse | dermal | 4 weeks | - | p.17 |
| Regulatory source | - | 250 | mg/kg | rat | - | 5 d | - | p.11 |
| Regulatory source | developmental toxicity | 35 | mg/kg/d | mouse | oral | - | developmental toxicity | p.13 |
| Regulatory source | developmental toxicity | 50 | mg/kg/d | rat | oral | - | developmental toxicity | p.13 |
| Regulatory source | developmental toxicity | 50 | mg/kg/d | rat | inhalation | - | developmental toxicity | p.14 |
| Regulatory source | developmental toxicity | 200 | mg/kg/ d | rat | oral | - | developmental toxicity | p.18 |
| Regulatory source | developmental toxicity | 350 | mg/kg/d | mouse | oral | - | developmental toxicity | p.13 |
| Regulatory source | developmental toxicity | 380 | mg/kg/d | rabbit | dermal | - | developmental toxicity | p.13 |
| Regulatory source | oral toxicity | 250 | mg/kg d | rat | oral | 7 weeks | oral toxicity | p.11 |
| Regulatory source | repeated dose toxicity | 1.5 | mg/m3 | rat | inhalation | 3 months | repeated dose toxicity | p.13 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | AZE05TDV2V | UNII | - | - | - | chemical | - |