Diglycosyl Hexapeptide-2

INCI: DIGLYCOSYL HEXAPEPTIDE-2

CAS Number
Not publicly listed (proprietary peptide derivative)
Function
Skin-lightening / anti-pigmentation agent — glycosylated derivative of Hexapeptide-2 (α-MSH antagonist, reduces melanin synthesis)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted — no CFR prohibition; however, skin-lightening claims may trigger FDA OTC drug scrutiny

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited independent safety data; relies primarily on supplier efficacy/safety dossier. Mechanism of action (α-MSH antagonism) is biologically active — ensure use levels match supplier recommendations. OTC drug classification risk in the US if marketed with lightening/whitening claims.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Diglycosyl Hexapeptide-2 safe in cosmetics?

Limited independent safety data; relies primarily on supplier efficacy/safety dossier. Mechanism of action (α-MSH antagonism) is biologically active — ensure use levels match supplier recommendations. OTC drug classification risk in the US if marketed with lightening/whitening claims. The EU classifies Diglycosyl Hexapeptide-2 as "prohibited". Safety rating: MODERATE.

Is Diglycosyl Hexapeptide-2 allowed in the EU?

Diglycosyl Hexapeptide-2 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Diglycosyl Hexapeptide-2 do in cosmetics?

Diglycosyl Hexapeptide-2 functions as: Skin-lightening / anti-pigmentation agent — glycosylated derivative of Hexapeptide-2 (α-MSH antagonist, reduces melanin synthesis). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly listed (proprietary peptide derivative).

What is the Margin of Safety for Diglycosyl Hexapeptide-2?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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