Dihydroquercetin Dithiolanepentyl Ether

INCI: DIHYDROQUERCETIN DITHIOLANEPENTYL ETHER

CAS Number
*Not confirmed — likely proprietary/novel derivative; verify with supplier*
Function
Antioxidant and skin conditioning agent; modified taxifolin derivative with enhanced lipophilicity
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not established. Parent compound DHQ has GRAS status for food (GRN 916); cosmetic use of this derivative not specifically addressed.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Major data gap: This is a novel specialty derivative. The dithiolane ring introduces sulfur chemistry that requires independent genotoxicity, sensitization, and repeated-dose toxicology evaluation. Parent DHQ is EFSA-approved and non-mutagenic, but structural modification voids read-across without formal justification. CPSR cannot rely on parent compound data alone. Supplier must provide full toxicology dossier.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Dihydroquercetin Dithiolanepentyl Ether safe in cosmetics?

Major data gap: This is a novel specialty derivative. The dithiolane ring introduces sulfur chemistry that requires independent genotoxicity, sensitization, and repeated-dose toxicology evaluation. Parent DHQ is EFSA-approved and non-mutagenic, but structural modification voids read-across without formal justification. CPSR cannot rely on parent compound data alone. Supplier must provide full toxicology dossier. The EU classifies Dihydroquercetin Dithiolanepentyl Ether as "permitted". Safety rating: MODERATE.

Is Dihydroquercetin Dithiolanepentyl Ether allowed in the EU?

Dihydroquercetin Dithiolanepentyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dihydroquercetin Dithiolanepentyl Ether do in cosmetics?

Dihydroquercetin Dithiolanepentyl Ether functions as: Antioxidant and skin conditioning agent; modified taxifolin derivative with enhanced lipophilicity. It is classified as a cosmetic ingredient in our database. CAS number: *Not confirmed — likely proprietary/novel derivative; verify with supplier*.

What is the Margin of Safety for Dihydroquercetin Dithiolanepentyl Ether?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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