Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Limited published toxicology; chalcone structures can act as Michael acceptors with theoretical sensitization risk. No SCCS opinion or CIR monograph available. Botanical-derived variants may carry additional impurity profiles. HRIPT testing recommended at intended use level.
Regulatory Flags
Frequently Asked Questions
Is Dihydroxydimethoxychalcone safe in cosmetics?
Limited published toxicology; chalcone structures can act as Michael acceptors with theoretical sensitization risk. No SCCS opinion or CIR monograph available. Botanical-derived variants may carry additional impurity profiles. HRIPT testing recommended at intended use level. The EU classifies Dihydroxydimethoxychalcone as "permitted". Safety rating: MODERATE.
Is Dihydroxydimethoxychalcone allowed in the EU?
Dihydroxydimethoxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dihydroxydimethoxychalcone do in cosmetics?
Dihydroxydimethoxychalcone functions as: Skin-conditioning agent; antioxidant; skin-lightening (tyrosinase inhibition pathway). It is classified as a cosmetic ingredient in our database. CAS number: 131496-17-2 (2',4'-dihydroxy-3,4-dimethoxychalcone, most common cosmetic isomer).
What is the Margin of Safety for Dihydroxydimethoxychalcone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Dihydroxydimethoxychalcone compliance across multiple jurisdictions:
Related Ingredients
Is Dihydroxydimethoxychalcone in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Dihydroxydimethoxychalcone in your formulation.