Dihydroxymethoxy Dihydrochalcone

INCI: DIHYDROXYMETHOXY DIHYDROCHALCONE

CAS Number
Not confirmed for INCI entry — related compound 4,4′-dihydroxy-2,6-dimethoxydihydrochalcone has CAS 151752-08-8
Function
Likely antioxidant based on chalcone pharmacophore structure
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically regulated; no CIR review identified

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Major data gap: no CIR monograph, no SCCS opinion, and function unspecified in CosIng; COX inhibitory activity reported in related isomers requires verification at cosmetic concentrations.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Dihydroxymethoxy Dihydrochalcone safe in cosmetics?

Major data gap: no CIR monograph, no SCCS opinion, and function unspecified in CosIng; COX inhibitory activity reported in related isomers requires verification at cosmetic concentrations. The EU classifies Dihydroxymethoxy Dihydrochalcone as "permitted". Safety rating: MODERATE.

Is Dihydroxymethoxy Dihydrochalcone allowed in the EU?

Dihydroxymethoxy Dihydrochalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dihydroxymethoxy Dihydrochalcone do in cosmetics?

Dihydroxymethoxy Dihydrochalcone functions as: Likely antioxidant based on chalcone pharmacophore structure. It is classified as a cosmetic ingredient in our database. CAS number: Not confirmed for INCI entry — related compound 4,4′-dihydroxy-2,6-dimethoxydihydrochalcone has CAS 151752-08-8.

What is the Margin of Safety for Dihydroxymethoxy Dihydrochalcone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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