Dimethoxy Di-p-Cresol

INCI: DIMETHOXY DI-P-CRESOL

CAS Number
13990-86-8
Function
Antioxidant, Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no specific CFR restriction; not on FDA prohibited list

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR concluded data were insufficient to support safety of parent p-cresol; depigmentation potential noted in animal studies at higher concentrations. China restricts leave-on use to โ‰ค0.01% on face/eyes. Needs full tox dossier for CPSR.

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Concern Level: Moderate

Frequently Asked Questions

Is Dimethoxy Di-p-Cresol safe in cosmetics?

CIR concluded data were insufficient to support safety of parent p-cresol; depigmentation potential noted in animal studies at higher concentrations. China restricts leave-on use to โ‰ค0.01% on face/eyes. Needs full tox dossier for CPSR. The EU classifies Dimethoxy Di-p-Cresol as "permitted". Safety rating: MODERATE.

Is Dimethoxy Di-p-Cresol allowed in the EU?

Dimethoxy Di-p-Cresol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethoxy Di-p-Cresol do in cosmetics?

Dimethoxy Di-p-Cresol functions as: Antioxidant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 13990-86-8.

What is the Margin of Safety for Dimethoxy Di-p-Cresol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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