Dimethoxyphenethyl Resorcinol

INCI: DIMETHOXYPHENETHYL RESORCINOL

CAS Number
Verify with supplier — structurally related to phenylethyl resorcinol (CAS 85-27-8) with added methoxy groups
Function
Skin lightening / tyrosinase inhibitor
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status restricted
US Notes Permitted — not specifically restricted; distinct from hydroquinone

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Sensitization is the primary concern with HRIPT testing mandatory. SCCS has flagged resorcinol for endocrine-disrupting properties affecting thyroid function; confirmation that this derivative does not share the same endocrine activity is required. Photostability testing is recommended given use in brightening products exposed to UV.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Dimethoxyphenethyl Resorcinol safe in cosmetics?

Sensitization is the primary concern with HRIPT testing mandatory. SCCS has flagged resorcinol for endocrine-disrupting properties affecting thyroid function; confirmation that this derivative does not share the same endocrine activity is required. Photostability testing is recommended given use in brightening products exposed to UV. The EU classifies Dimethoxyphenethyl Resorcinol as "prohibited". Safety rating: MODERATE.

Is Dimethoxyphenethyl Resorcinol allowed in the EU?

Dimethoxyphenethyl Resorcinol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethoxyphenethyl Resorcinol do in cosmetics?

Dimethoxyphenethyl Resorcinol functions as: Skin lightening / tyrosinase inhibitor. It is classified as a cosmetic ingredient in our database. CAS number: Verify with supplier — structurally related to phenylethyl resorcinol (CAS 85-27-8) with added methoxy groups.

What is the Margin of Safety for Dimethoxyphenethyl Resorcinol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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