Good Cosmetic Ingredient NOAEL Data

Dimethyl Heptenal

INCI: DIMETHYL HEPTENAL

CAS Number
106-72-9
Function
Fragrance ingredient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — RIFM assessed; FEMA GRAS

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Dimethyl Heptenal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 160 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOEL 300 mg/kg bw/day oral rat oral REACH

Expert Verdict

Confirmed skin sensitizer from citral/citronellal family; IFRA Amendment restricts maximum use level by product category; must comply with IFRA 50th Amendment standards; α,β-unsaturated aldehyde.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Dimethyl Heptenal safe in cosmetics?

Confirmed skin sensitizer from citral/citronellal family; IFRA Amendment restricts maximum use level by product category; must comply with IFRA 50th Amendment standards; α,β-unsaturated aldehyde. The EU classifies Dimethyl Heptenal as "restricted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Dimethyl Heptenal allowed in the EU?

Dimethyl Heptenal EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethyl Heptenal do in cosmetics?

Dimethyl Heptenal functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 106-72-9.

What is the Margin of Safety for Dimethyl Heptenal?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dimethyl Heptenal?

The NOAEL (No Observed Adverse Effect Level) for Dimethyl Heptenal is 160 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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