Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Dimethylaminoethanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >7 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >240 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
DMAE is an EU Annex III restricted substance (max 2.5% leave-on) due to its trialkylamine classification, with mandatory nitrosamine controls. Margin of safety calculations fall substantially below the SCCS threshold of 100 at the permitted limit, raising substantive safety concerns for leave-on applications.
Regulatory Flags
Frequently Asked Questions
Is Dimethylaminoethanol safe in cosmetics?
DMAE is an EU Annex III restricted substance (max 2.5% leave-on) due to its trialkylamine classification, with mandatory nitrosamine controls. Margin of safety calculations fall substantially below the SCCS threshold of 100 at the permitted limit, raising substantive safety concerns for leave-on applications. The EU classifies Dimethylaminoethanol as "restricted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Dimethylaminoethanol allowed in the EU?
Dimethylaminoethanol EU regulatory status: restricted. Maximum allowed concentration: 2.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethylaminoethanol do in cosmetics?
Dimethylaminoethanol functions as: pH Regulator, Buffering Agent. It is classified as a cosmetic ingredient in our database. CAS number: 108-01-0.
What is the Margin of Safety for Dimethylaminoethanol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethylaminoethanol?
The NOAEL (No Observed Adverse Effect Level) for Dimethylaminoethanol is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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