NOAEL Studies Cosmetic Ingredient

Dimethyl Urea NOAEL Studies

INCI: DIMETHYL UREA

CAS: 96-31-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =150 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce568; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10061/7/6/2?documentUUID=d444b2c5-0c58-4d39-b918-ccf9002fbd48; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838416_15850036:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4898cb209f8250e96d5bd177e8a48744
ToxValDB_ECHA_IUCLID LOAEL =500 mg/kg bw/day Rat oral chronic; 20 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce56f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10061/7/6/2?documentUUID=d444b2c5-0c58-4d39-b918-ccf9002fbd48; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15848209:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c5686809e68bd48a8c7dc745ccfec214
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfd98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10061/7/9/3?documentUUID=d444b2c5-0c58-4d39-b918-ccf9002fbd48; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15825327:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aaeee4caa0f4568393ffc58de2b14e2e
ToxValDB_ECHA_IUCLID NOAEL =30 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfd9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10061/7/9/3?documentUUID=d444b2c5-0c58-4d39-b918-ccf9002fbd48; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15825328:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1c168f116ef6df8825ec92422716a17f
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8de4b0a7c65d1ce568; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10061/7/6/2?documentUUID=d444b2c5-0c58-4d39-b918-ccf9002fbd48; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838416_15850036:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c93188d010edae18038466e4c266d135
ToxValDB_ECHA_IUCLID NOAEL =60 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1bae3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10061/7/9/2?documentUUID=d444b2c5-0c58-4d39-b918-ccf9002fbd48; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856345_15863077:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_562f804eb00fd7fd1582ae5b468f42cb
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier WAM6DR9I4X UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H8N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WAM6DR9I4X"}
openFDA substances FDA UNII substance identifier WAM6DR9I4X UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H8N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WAM6DR9I4X"}
openFDA substances FDA UNII substance identifier WAM6DR9I4X UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H8N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WAM6DR9I4X"}
openFDA substances FDA UNII substance identifier WAM6DR9I4X UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H8N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WAM6DR9I4X"}