Good Cosmetic Ingredient NOAEL Data

Dimethyldibenzylidene Sorbitol

INCI: DIMETHYLDIBENZYLIDENE SORBITOL

CAS Number
135861-56-2
Function
Viscosity controlling agent (gelling/structuring agent)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” also listed in FDA Inventory of Food Contact Substances under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Dimethyldibenzylidene Sorbitol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2000 ppm oral rat Subchronic COSMOS_DB
LOAEL 6500 ppm oral rat Subchronic COSMOS_DB

Expert Verdict

Not classified as acutely toxic, irritant, sensitizer, mutagenic, or carcinogenic. Inhalation of powder form should be avoided (standard PPE recommendation). Minimal cosmetic-specific published data beyond SDS.

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Concern Level: Low

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Dimethyldibenzylidene Sorbitol safe in cosmetics?

Not classified as acutely toxic, irritant, sensitizer, mutagenic, or carcinogenic. Inhalation of powder form should be avoided (standard PPE recommendation). Minimal cosmetic-specific published data beyond SDS. The EU classifies Dimethyldibenzylidene Sorbitol as "prohibited". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Dimethyldibenzylidene Sorbitol allowed in the EU?

Dimethyldibenzylidene Sorbitol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dimethyldibenzylidene Sorbitol do in cosmetics?

Dimethyldibenzylidene Sorbitol functions as: Viscosity controlling agent (gelling/structuring agent). It is classified as a cosmetic ingredient in our database. CAS number: 135861-56-2.

What is the Margin of Safety for Dimethyldibenzylidene Sorbitol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dimethyldibenzylidene Sorbitol?

The NOAEL (No Observed Adverse Effect Level) for Dimethyldibenzylidene Sorbitol is 2000 ppm based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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