Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Dimethylhydroxy Furanone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 6.15 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 6.15 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | >=400 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 101.5 ppm | oral | rat | oral | REACH |
Expert Verdict
Skin sensitizer with QRA2 restrictions; harmful if swallowed (H302); severe skin burns/eye damage at concentrate (H314); allergic skin reaction risk (H317)
Regulatory Flags
Frequently Asked Questions
Is Dimethylhydroxy Furanone safe in cosmetics?
Skin sensitizer with QRA2 restrictions; harmful if swallowed (H302); severe skin burns/eye damage at concentrate (H314); allergic skin reaction risk (H317) The EU classifies Dimethylhydroxy Furanone as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Dimethylhydroxy Furanone allowed in the EU?
Dimethylhydroxy Furanone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethylhydroxy Furanone do in cosmetics?
Dimethylhydroxy Furanone functions as: Fragrance (masking/perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 3658-77-3.
What is the Margin of Safety for Dimethylhydroxy Furanone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethylhydroxy Furanone?
The NOAEL (No Observed Adverse Effect Level) for Dimethylhydroxy Furanone is 6.15 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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