Dinonoxynol-4 Phosphate

INCI: DINONOXYNOL-4 PHOSPHATE

CAS Number
Not individually assigned; parent nonoxynol phosphate CAS 51609-41-7
Function
Surfactant / emulsifier (alkyl phosphate ester of dinonylphenol ethoxylate)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR reviewed nonoxynols as safe โ‰ค5% in leave-on products; alkyl phosphates also assessed as safe in current practices of use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Dinonylphenol backbone raises endocrine disruption concerns; nonylphenol residues may be present (<500 ppm); EU-banned class; aquatic toxicity of parent alkylphenol

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Concern Level: High

Frequently Asked Questions

Is Dinonoxynol-4 Phosphate safe in cosmetics?

Dinonylphenol backbone raises endocrine disruption concerns; nonylphenol residues may be present (<500 ppm); EU-banned class; aquatic toxicity of parent alkylphenol The EU classifies Dinonoxynol-4 Phosphate as "prohibited". Safety rating: MODERATE.

Is Dinonoxynol-4 Phosphate allowed in the EU?

Dinonoxynol-4 Phosphate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dinonoxynol-4 Phosphate do in cosmetics?

Dinonoxynol-4 Phosphate functions as: Surfactant / emulsifier (alkyl phosphate ester of dinonylphenol ethoxylate). It is classified as a cosmetic ingredient in our database. CAS number: Not individually assigned; parent nonoxynol phosphate CAS 51609-41-7.

What is the Margin of Safety for Dinonoxynol-4 Phosphate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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