Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Diosmine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=620 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | >=250 mg/kg bw/day | oral | code:3541 | oral | REACH |
Expert Verdict
Primarily a pharmaceutical phlebotropic agent; ensure cosmetic claims do not cross into drug/medicinal territory; limited cosmetic-specific dermal safety studies despite extensive oral safety record.
Frequently Asked Questions
Is Diosmine safe in cosmetics?
Primarily a pharmaceutical phlebotropic agent; ensure cosmetic claims do not cross into drug/medicinal territory; limited cosmetic-specific dermal safety studies despite extensive oral safety record. The EU classifies Diosmine as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Diosmine allowed in the EU?
Diosmine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diosmine do in cosmetics?
Diosmine functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 520-27-4.
What is the Margin of Safety for Diosmine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diosmine?
The NOAEL (No Observed Adverse Effect Level) for Diosmine is >=200 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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