Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
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Expert Verdict
No specific safety alerts; antioxidant properties noted. Most commonly used as Palmitoyl Dipeptide-52 (trade name Silverfree by Sederma). Amino acid sequence: Pal-Pro-Pro (two proline residues). The rigid angular geometry of proline is essential for melanocyte stimulation in hair follicles. Clinical tests showed reduction of white hair appearance by 32-86% and original color recovery of 27-385% with 1.5% concentration
Frequently Asked Questions
Is Dipeptide-52 safe in cosmetics?
No specific safety alerts; antioxidant properties noted. Most commonly used as Palmitoyl Dipeptide-52 (trade name Silverfree by Sederma). Amino acid sequence: Pal-Pro-Pro (two proline residues). The rigid angular geometry of proline is essential for melanocyte stimulation in hair follicles. Clinical tests showed reduction of white hair appearance by 32-86% and original color recovery of 27-385% with 1.5% concentration The EU classifies Dipeptide-52 as "permitted". Safety rating: MODERATE.
Is Dipeptide-52 allowed in the EU?
Dipeptide-52 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dipeptide-52 do in cosmetics?
Dipeptide-52 functions as: Skin Conditioning (base form); pro-pigmenting / hair repigmentation (as Palmitoyl Dipeptide-52). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly listed for the base dipeptide (the palmitoylated derivative has separate registration).
What is the Margin of Safety for Dipeptide-52?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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