Diphylleia Grayi Extract

INCI: DIPHYLLEIA GRAYI EXTRACT

CAS Number
Not assigned
Function
Skin conditioning (biological activities studied for cosmetic application)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” botanical extract; not prohibited under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Whole-plant extract may carry higher alkaloid load than callus culture; podophyllotoxin-class compounds are cytotoxic; mandatory compositional profiling and contaminant screening required; solvent residue specification needed

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Diphylleia Grayi Extract safe in cosmetics?

Whole-plant extract may carry higher alkaloid load than callus culture; podophyllotoxin-class compounds are cytotoxic; mandatory compositional profiling and contaminant screening required; solvent residue specification needed The EU classifies Diphylleia Grayi Extract as "restricted". Safety rating: MODERATE.

Is Diphylleia Grayi Extract allowed in the EU?

Diphylleia Grayi Extract EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diphylleia Grayi Extract do in cosmetics?

Diphylleia Grayi Extract functions as: Skin conditioning (biological activities studied for cosmetic application). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Diphylleia Grayi Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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