Dipivaloyl Cyclohexylcaffeate

INCI: DIPIVALOYL CYCLOHEXYLCAFFEATE

CAS Number
Not assigned in CosIng
Function
Skin conditioning (caffeic acid derivative — likely antioxidant function)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — not prohibited or restricted under 21 CFR; no CIR review found

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No SCCS or CIR evaluation; caffeic acid itself is IARC Group 2B (possibly carcinogenic) — ester prodrug hydrolysis must be characterized; requires in vitro genotoxicity panel (Ames, micronucleus), dermal absorption study, and HRIPT before CPSR clearance

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Concern Level: Moderate

Frequently Asked Questions

Is Dipivaloyl Cyclohexylcaffeate safe in cosmetics?

No SCCS or CIR evaluation; caffeic acid itself is IARC Group 2B (possibly carcinogenic) — ester prodrug hydrolysis must be characterized; requires in vitro genotoxicity panel (Ames, micronucleus), dermal absorption study, and HRIPT before CPSR clearance The EU classifies Dipivaloyl Cyclohexylcaffeate as "restricted". Safety rating: MODERATE.

Is Dipivaloyl Cyclohexylcaffeate allowed in the EU?

Dipivaloyl Cyclohexylcaffeate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dipivaloyl Cyclohexylcaffeate do in cosmetics?

Dipivaloyl Cyclohexylcaffeate functions as: Skin conditioning (caffeic acid derivative — likely antioxidant function). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned in CosIng.

What is the Margin of Safety for Dipivaloyl Cyclohexylcaffeate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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