Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Dipropyl Ketone

INCI: DIPROPYL KETONE

CAS Number
123-19-3
Function
Solvent, flavoring agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific 21 CFR cosmetic prohibition; FDA GRAS for flavoring use only, not cosmetic applications

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Dipropyl Ketone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 714 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is mildly irritating to the eyes and skin. The vapour is irritating to the respiratory tract. Exposure at high levels could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Skin and eye irritant with inhalation hazard potential; no cosmetic-specific safety review exists.

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Concern Level: Moderate

Regulatory Flags

ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Dipropyl Ketone safe in cosmetics?

Skin and eye irritant with inhalation hazard potential; no cosmetic-specific safety review exists. The EU classifies Dipropyl Ketone as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Dipropyl Ketone allowed in the EU?

Dipropyl Ketone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dipropyl Ketone do in cosmetics?

Dipropyl Ketone functions as: Solvent, flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 123-19-3.

What is the Margin of Safety for Dipropyl Ketone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dipropyl Ketone?

The NOAEL (No Observed Adverse Effect Level) for Dipropyl Ketone is 714 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. Source: COSMOS_DB.

Compliance Tools

Check Dipropyl Ketone compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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