Poor Cosmetic Ingredient NOAEL Data

Dipropylene Glycol Diacrylate ⚠️

INCI: DIPROPYLENE GLYCOL DIACRYLATE

CAS Number
57472-68-1
Function
Industrial UV-curable monomer
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not listed for cosmetic use; California Prop 65 toluene residue concern

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Dipropylene Glycol Diacrylate ⚠️. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 20 mg/kg bw/day dermal rat dermal REACH
NOAEL 375 mg/kg bw/day oral rat oral REACH
NOAEL 125 mg/kg bw/day oral rat oral REACH
LOAEL 20 mg/kg bw/day dermal - dermal REACH
NOAEL 375 mg/kg bw/day oral - oral REACH

Expert Verdict

Acrylate monomer with documented contact allergen properties; exhibits H315 skin irritation, H317 allergic skin reaction, and H318 serious eye damage hazards; contraindicated for cosmetic application.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Dipropylene Glycol Diacrylate ⚠️ safe in cosmetics?

Acrylate monomer with documented contact allergen properties; exhibits H315 skin irritation, H317 allergic skin reaction, and H318 serious eye damage hazards; contraindicated for cosmetic application. The EU classifies Dipropylene Glycol Diacrylate ⚠️ as "prohibited". Safety rating: POOR. 5 toxicological study endpoint(s) are available in our database.

Is Dipropylene Glycol Diacrylate ⚠️ allowed in the EU?

Dipropylene Glycol Diacrylate ⚠️ EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dipropylene Glycol Diacrylate ⚠️ do in cosmetics?

Dipropylene Glycol Diacrylate ⚠️ functions as: Industrial UV-curable monomer. It is classified as a cosmetic ingredient in our database. CAS number: 57472-68-1.

What is the Margin of Safety for Dipropylene Glycol Diacrylate ⚠️?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dipropylene Glycol Diacrylate ⚠️?

The NOAEL (No Observed Adverse Effect Level) for Dipropylene Glycol Diacrylate ⚠️ is 20 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 5 study endpoints are available. Source: REACH.

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