Disodium Caproamphodiacetate

INCI: DISODIUM CAPROAMPHODIACETATE

CAS Number
68608-64-0 (shared registry with amphoteric fatty acid derivatives)
Function
Surfactant — cleansing, foam boosting, hair/skin conditioning (amphoteric)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no 21 CFR restriction; CIR reviewed the cocoamphodiacetate class as safe (1990, reaffirmed 2008)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Amidoamine and AEEA impurity levels must be controlled (known sensitizers); C6 chain = shorter than coco variants, expect similar or better tolerance; CIR noted NOAEL of 1000 mg/kg bw/d for disodium cocoamphodiacetate in 90-day oral study

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Disodium Caproamphodiacetate safe in cosmetics?

Amidoamine and AEEA impurity levels must be controlled (known sensitizers); C6 chain = shorter than coco variants, expect similar or better tolerance; CIR noted NOAEL of 1000 mg/kg bw/d for disodium cocoamphodiacetate in 90-day oral study The EU classifies Disodium Caproamphodiacetate as "permitted". Safety rating: GOOD.

Is Disodium Caproamphodiacetate allowed in the EU?

Disodium Caproamphodiacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Disodium Caproamphodiacetate do in cosmetics?

Disodium Caproamphodiacetate functions as: Surfactant — cleansing, foam boosting, hair/skin conditioning (amphoteric). It is classified as a cosmetic ingredient in our database. CAS number: 68608-64-0 (shared registry with amphoteric fatty acid derivatives).

What is the Margin of Safety for Disodium Caproamphodiacetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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