Good Cosmetic Ingredient NOAEL Data

Disodium Capryloyl Glutamate

INCI: DISODIUM CAPRYLOYL GLUTAMATE

CAS Number
167888-81-5
Function
Surfactant, Cleansing, Deodorant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR 2017 (Burnett et al.): safe in present practices of use and concentration when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Disodium Capryloyl Glutamate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1200 mg/kg bw/day oral rat oral REACH
NOAEL 1200 mg/kg bw/day oral rat oral REACH

Expert Verdict

Mild amino acid-derived anionic surfactant from plant/fermentation sources. CIR 2017 concluded safe when formulated to be non-irritating. Not restricted under any EU Annex. COSMOS/ECOCERT eligible.

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Concern Level: Low

Regulatory Flags

surfactant amino-acid-derived plant-derived sulfate-free mild cleansing cosmos-eligible cir-reviewed no-eu-restrictions

Frequently Asked Questions

Is Disodium Capryloyl Glutamate safe in cosmetics?

Mild amino acid-derived anionic surfactant from plant/fermentation sources. CIR 2017 concluded safe when formulated to be non-irritating. Not restricted under any EU Annex. COSMOS/ECOCERT eligible. The EU classifies Disodium Capryloyl Glutamate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Disodium Capryloyl Glutamate allowed in the EU?

Disodium Capryloyl Glutamate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Disodium Capryloyl Glutamate do in cosmetics?

Disodium Capryloyl Glutamate functions as: Surfactant, Cleansing, Deodorant. It is classified as a cosmetic ingredient in our database. CAS number: 167888-81-5.

What is the Margin of Safety for Disodium Capryloyl Glutamate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Disodium Capryloyl Glutamate?

The NOAEL (No Observed Adverse Effect Level) for Disodium Capryloyl Glutamate is 1200 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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