NOAEL Studies Cosmetic Ingredient

Disodium EDTA NOAEL Studies

INCI: DISODIUM EDTA

CAS: 139-33-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 375 mg/kg bw/day rat oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 750 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 954 mg/kg bw/day rat oral 8 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 21 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1125 mg/kg bw/day mouse oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1243 mg/kg bw/day rat oral 8 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1250 mg/kg bw/day rat oral 8 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_2556; row=15711; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylenediaminetetraacetic acid, disodium salt; preferred_name=Ethylenediaminetetraacetic acid, disodium salt; dtxsid=DTXSID9027073; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027073; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3700 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2558; row=15710; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylenediaminetetraacetic acid, disodium salt; preferred_name=Ethylenediaminetetraacetic acid, disodium salt; dtxsid=DTXSID9027073; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027073; source_file=acute_oral.xlsx
NTP_ICE_skin_irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Positive reaction 0 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1862; Record_ID=skin_irritation_invivo_8; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9027073; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027073
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL ~30 mg/m3 Rat inhalation - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/3/3?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15797467:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1657f3b4948550893781c7b5c9b38a9d
ToxValDB_ECHA_IUCLID LOAEC =15 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/6/3?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15828343:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9e7b42dd0175c2d0fa586d911ba7bdaf
ToxValDB_ECHA_IUCLID LOAEC =30 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/6/3?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15827949:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_123801adbf5b8b695babdc79f0eb1fb3
ToxValDB_ECHA_IUCLID NOAEC =3 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/6/3?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15828345:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_845fdfd24bc1ad013f3623af53adaa40
ToxValDB_ECHA_IUCLID NOAEL >=15 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa99e4b0a7c65d1b69df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/9/2?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15861905:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7096e47a2e08682c9d70b8fdadd2aa95
ToxValDB_ECHA_IUCLID NOAEL =954 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc61b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/9/3?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15824328:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d0fb0aac3356b47d9b6e035354af1302
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc618; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/9/3?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15824326:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4728742fe7f0ba08b67ffcab2611f798
ToxValDB_ECHA_IUCLID NOAEL =1125 mg/kg bw/day Rat oral subchronic; 1 months subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3c79; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14817/7/6/2?documentUUID=37bf4d58-28f6-4838-a489-61df9eca38a4; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=body weight and weight gain|gross pathology|haematology|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|hematology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15848078:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ea426398b1dc87ee7510724e4291c9dd
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =1.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631626_15631627:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ed0c7b250ab2f71fa754aab98c6a8e6
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8NLQ36F6MM UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14N2O8.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8NLQ36F6MM"}
openFDA substances FDA UNII substance identifier 8NLQ36F6MM UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14N2O8.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8NLQ36F6MM"}
openFDA substances FDA UNII substance identifier 8NLQ36F6MM UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14N2O8.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8NLQ36F6MM"}
openFDA substances FDA UNII substance identifier 8NLQ36F6MM UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14N2O8.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8NLQ36F6MM"}