Disodium Itaconate

INCI: DISODIUM ITACONATE

CAS Number
5363-69-9
Function
Buffering / pH control agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR reviewed dicarboxylic acids, salts, and esters as safe as used (2012)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited cosmetic-specific standalone data; safety supported primarily by read-across from itaconic acid and dicarboxylic acid class; resorption increase at very high oral dose (1300 mg/kg) was within normal limits.

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Concern Level: Low

Frequently Asked Questions

Is Disodium Itaconate safe in cosmetics?

Limited cosmetic-specific standalone data; safety supported primarily by read-across from itaconic acid and dicarboxylic acid class; resorption increase at very high oral dose (1300 mg/kg) was within normal limits. The EU classifies Disodium Itaconate as "permitted". Safety rating: GOOD.

Is Disodium Itaconate allowed in the EU?

Disodium Itaconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Disodium Itaconate do in cosmetics?

Disodium Itaconate functions as: Buffering / pH control agent. It is classified as a cosmetic ingredient in our database. CAS number: 5363-69-9.

What is the Margin of Safety for Disodium Itaconate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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