NOAEL Studies Cosmetic Ingredient

DISODIUM SELENITE NOAEL Studies

CAS: 10102-18-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =15 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218e4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15856207:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_22e7cd96a9828cf41ecd402ac5cb8cf9
ECHA LEL =5000 mg/m3 Rat inhalation - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/3/3?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15798802_15799630_15799631:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cd8e6d0a5f0a0c123443e26b1ba5fc23
ECHA LOAEL =0.34 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb330; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/3?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=maternal: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15823884:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6b80356386d4fa58113d283183c02bf7
ECHA LOAEL =0.6 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b51f9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: reproductive function (sperm measures); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855168_15861236_15861439_15861888_15862259:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54efa9620fc8ce11c6a90ccebea9bfba
ECHA LOAEL =2 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9cef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11470/7/9/2?documentUUID=26876aed-0f1d-49ad-b656-eb744f180df2; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856364_15860552_15860558_15860657_15861580:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cc5e0dec4efd069534d0d1226590cf6d
ECHA LOAEL =4 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b5201; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=P0: reproductive function (sperm measures); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856364_15860552_15860558_15860657_15861580:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c7b3d35db925d5724509b254d92caed
ECHA LOAEL =6 ppm Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218e2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ECHA IUCLID:15855352:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0df1875fe9ab19da62edd5fa565e04fc
ECHA LOAEL =7.5 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218e4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15855381:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_614f379b9f903e020c4eaf8ba4a47235
ECHA LOAEL =30 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218e4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=F1: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15859347:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a194e82c07733235f83e12664a981db1
ECHA NOAEL =0.12 mg/kg bw/day Rat oral subchronic; 2 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb76c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11470/7/6/2?documentUUID=26876aed-0f1d-49ad-b656-eb744f180df2; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850175_15850176_15850177_15850178:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_04a566718ac7a7ca408b5f59553d1696
ECHA NOAEL =0.14 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead4be4b0a7c65d1c3836; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5197/7/6/2?documentUUID=c9e1406c-6ce9-4892-8a85-ee58b3f3d01c; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|gross pathology|haematology|histopathology: neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|gross pathology|hematology|organ weight; STUDY_GROUP=ECHA IUCLID:15850700:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_480926f5451298a63b59d92ed6d9a226
ECHA NOAEL =0.2 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead4be4b0a7c65d1c3836; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5197/7/6/2?documentUUID=c9e1406c-6ce9-4892-8a85-ee58b3f3d01c; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|gross pathology|haematology|histopathology: neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|gross pathology|hematology|organ weight; STUDY_GROUP=ECHA IUCLID:15850701:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_eea60dfe75dbc43916e6cb4206fdbfe7
ECHA NOAEL =0.35 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6636; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25874/7/9/2?documentUUID=130c3588-baa2-4028-aeec-a214f77f2b8f; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: reproductive function (sperm measures); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855168_15861236_15861439_15861888_15862259:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_caf1a8e2c54be8c34512f1933e0f7c07
ECHA NOAEL =0.36 mg/kg bw/day Mouse oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca6ae4b0a7c65d221caf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25874/7/6/2?documentUUID=130c3588-baa2-4028-aeec-a214f77f2b8f; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850154_15850155_15850156_15850157:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_489c3424fd5cbccc6df7360a3d422b13
ECHA NOAEL =0.4 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c341a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25874/7/6/2?documentUUID=130c3588-baa2-4028-aeec-a214f77f2b8f; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=body weight and weight gain|mortality|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850179_15850180_15850181_15850182:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2bd8e2b6733e2978bf05f62e16926085
ECHA NOAEL =0.5 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218e80; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=P0: reproductive function (oestrous cycle); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15855533:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_604fe97edbd95597f7ecfa614d650ee2
ECHA NOAEL =0.68 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb330; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/3?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15823885:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2ab9e549df13e2831ae1772b512c1380
ECHA NOAEL =0.756 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb75c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11470/7/6/2?documentUUID=26876aed-0f1d-49ad-b656-eb744f180df2; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=body weight and weight gain|gross pathology|histopathology: neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|gross pathology|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850162_15850163_15850164_15850165:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_25548b6caaa7e22b9f453ef60d218bcf
ECHA NOAEL =0.9 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb770; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11470/7/6/2?documentUUID=26876aed-0f1d-49ad-b656-eb744f180df2; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=body weight and weight gain|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850158_15850159_15850160_15850161:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_07f4093515fda6eb3dff5adb5ba5e60d
ECHA NOAEL >=1.6 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218e80; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11204/7/9/2?documentUUID=040e02e9-b9dc-45d9-8baf-44866dceab17; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=P0: reproductive function (sperm measures); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15856338:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2bd9d99dde4b31823c053e0422f7036c
ECHA NOAEL =2 mg/kg bw/day Rat injection - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d216e4b0a7c65d2316d9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11470/7/9/3?documentUUID=26876aed-0f1d-49ad-b656-eb744f180df2; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820908_15821009_15821415_15821444:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_da3e32e09666aefb43a5708f88bd1ebd
ToxValDB ECOTOX 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =0.048 mg/kg bw/day Rat oral subchronic; 75 days subchronic LONG_REF=- | J. Nutr.103(4): 560-568 Shull,L.R., and P.R. Cheeke Antiselenium Activity of Tri-o-cresyl Phosphate in Rats and Japanese Quail 1973; TITLE=Antiselenium Activity of Tri-o-cresyl Phosphate in Rats and Japanese Quail; AUTHOR=Shull,L.R., and P.R. Cheeke; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=54179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1973; ORIGINAL_YEAR=1973; TOXICOLOGICAL_EFFECT=Increased bodyweight; Increased lipase activity; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=ECOTOX:15613574:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=1a7dadc8234663a7ee341305067ca83b
ToxValDB ECOTOX LOEL =0.09 mg/kg bw/day Rat oral short-term; 4 weeks short-term LONG_REF=- | Biol. Trace Elem. Res.49:177-186 Glattre,E., A. Mravcova, J. Lener, M. Vobecky, E. Egertova, and M. Mysliveckova Study of Distribution and Interaction of Arsenic and Selenium in Rat Thyroid 1995; TITLE=Study of Distribution and Interaction of Arsenic and Selenium in Rat Thyroid; AUTHOR=Glattre,E., A. Mravcova, J. Lener, M. Vobecky, E. Egertova, and M. Mysliveckova; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=69350; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Hormone(s): T3 | Hormone(s): T4 | Weight: Bodyweight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX:15613137:F:-juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=b5b0566a8d048969a3bab7e25f9571b5
ToxValDB ECOTOX LOEL =0.5 ppm Rat oral short-term; 30 days short-term LONG_REF=Biomed. Environ. Sci.25(3): 340-351 Amara,I.B., N. Soudani, A. Troudi, A. Hakim, K.M. Zeghal, T. Boudawara, and N. Zeghal Dimethoate Induced Oxidative Damage and Histopathological Changes in Lung of Adult Rats: Modulatory Effects of Selenium and/or Vitamin E 2012; TITLE=Dimethoate Induced Oxidative Damage and Histopathological Changes in Lung of Adult Rats: Modulatory Effects of Selenium and/or Vitamin E; AUTHOR=Amara,I.B., N. Soudani, A. Troudi, A. Hakim, K.M. Zeghal, T. Boudawara, and N. Zeghal; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=162818; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Biochemistry: Protein carbonyls; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600838_15600839:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6fe7ee3c6fa0939d687e2d1d353115c6
ToxValDB ECOTOX LOEL =192 mg/kg bw/day Rat oral subchronic; 84 days subchronic LONG_REF=- | Can. J. Vet. Res.65(2): 104-110 Aburto,E.M., A. Cribb, I.C. Fuentealba, B.O. Ikede, F.S.B. Kibenge, and F. Markham The Failure of Selenium Supplementation to Prevent Copper-Induced Liver Damage in Fischer 344 Rats 2001; TITLE=The Failure of Selenium Supplementation to Prevent Copper-Induced Liver Damage in Fischer 344 Rats; AUTHOR=Aburto,E.M., A. Cribb, I.C. Fuentealba, B.O. Ikede, F.S.B. Kibenge, and F. Markham; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97812; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Enzyme(s): Heptaic glutathione peroxidase decrease| Histology: histochemistry| Metal analysis: hepatic Cu and Se; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15613305:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=f610b86cd5ac93c0aafdc11045b831b5
ToxValDB ECOTOX NOEL =1.44 mg/kg bw/day Rat oral subchronic; 42 days subchronic LONG_REF=Biol. Trace Elem. Res.77(3): 241-249 Tatum,L., P. Shankar, L.M. Boylan, and J.E. Spallholz Effect of Dietary Copper on Selenium Toxicity in Fischer 344 Rats 2000; TITLE=Effect of Dietary Copper on Selenium Toxicity in Fischer 344 Rats; AUTHOR=Tatum,L., P. Shankar, L.M. Boylan, and J.E. Spallholz; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76894; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598598_15604960:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f351d7017ccb314c9b32bea5a6d20d37
ToxValDB ECOTOX NOEL =7 mg/L Mouse oral subchronic; 47 days subchronic LONG_REF=In: T.Garland and A.C.Barr (Eds.), Toxic Plants and Other Natural Toxicants, CABI Publishing, New York, NY53:260-266 Raisbeck,M.F., R.A. Schamber, and E.L. Belden Immunotoxic Effects of Selenium in Mammals 1998; TITLE=Immunotoxic Effects of Selenium in Mammals; AUTHOR=Raisbeck,M.F., R.A. Schamber, and E.L. Belden; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=170475; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Cell(s): B-cell; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15600827:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=686c48e5a902a2763461483431970694
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.11 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634875:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf5e081a96a75dfed9cfc59a2a47a351
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL =0.17 mg/kg bw/day Rat oral - subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e15e4b0a676289df5f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Water Consumption: decrease|Histopathology: Kidney-Papilla, degeneration|Reproductive Tissue Evaluation: Epididymal spermatozoal measurements-Concentration decrease; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=HESS:15639024:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dd22094385894660dc0a3181a6e33142
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier HIW548RQ3W UNII - - - chemical -