Disodium Succinoyl Glycyrrhetinate

INCI: DISODIUM SUCCINOYL GLYCYRRHETINATE

CAS Number
7421-40-1
Function
Skin conditioning, surfactant - cleansing, surfactant - foam boosting
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted - no specific CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR noted glycyrrhizic acid is cytotoxic at high doses and systemic ingestion can have physiological effects (pseudoaldosteronism), but poor dermal absorption mitigates risk. Not phototoxic, not a photosensitizer. EU SCF upper limit of 100 mg/day for oral ingestion does not apply to topical cosmetic use.

โš ๏ธ
Concern Level: Low

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Disodium Succinoyl Glycyrrhetinate safe in cosmetics?

CIR noted glycyrrhizic acid is cytotoxic at high doses and systemic ingestion can have physiological effects (pseudoaldosteronism), but poor dermal absorption mitigates risk. Not phototoxic, not a photosensitizer. EU SCF upper limit of 100 mg/day for oral ingestion does not apply to topical cosmetic use. The EU classifies Disodium Succinoyl Glycyrrhetinate as "permitted". Safety rating: EXCELLENT.

Is Disodium Succinoyl Glycyrrhetinate allowed in the EU?

Disodium Succinoyl Glycyrrhetinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Disodium Succinoyl Glycyrrhetinate do in cosmetics?

Disodium Succinoyl Glycyrrhetinate functions as: Skin conditioning, surfactant - cleansing, surfactant - foam boosting. It is classified as a cosmetic ingredient in our database. CAS number: 7421-40-1.

What is the Margin of Safety for Disodium Succinoyl Glycyrrhetinate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Disodium Succinoyl Glycyrrhetinate in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Disodium Succinoyl Glycyrrhetinate in your formulation.