NOAEL Studies Cosmetic Ingredient

Disperse Blue 377 NOAEL Studies

INCI: DISPERSE BLUE 377

CAS: 4471-41-4 / 67674-26-4 / 67701-36-4 (three isomers)

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =25 mg/kg/day rat oral 91 days repeated dose toxicity p.18
SCCS Opinion NOAEL =75 mg/kg bw/d - - Chronic genotoxicity Ref.: 9 (subm I) 3, p.20
SCCS Opinion NOAEL =500 mg/kg bw/d - - developmental developmental toxicity p.27
SCCS Opinion NOAEL =34.8 mg/kg bw/d human - developmental developmental toxicity Ref.: 14 (subm I) 3, p.29
SCCS Opinion NOAEL =0.001 mg/kg rat oral subchronic repeated dose toxicity p.30
SCCS Opinion NOAEL =2000 mg/kg bw rat oral developmental repeated dose toxicity p.30
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 500 mg/kg bw/d - - developmental developmental toxicity p.27
Regulatory source developmental toxicity 75 mg/kg bw/d - - developmental developmental toxicity p.29
Regulatory source developmental toxicity 34.8 mg/kg bw/d human - developmental developmental toxicity p.29
Regulatory source genotoxicity 75 mg/kg bw/d - - Chronic genotoxicity p.20
Regulatory source repeated dose toxicity 25 mg/kg/day rat oral 91 days repeated dose toxicity p.18
Regulatory source repeated dose toxicity =0.001 mg/kg rat oral subchronic repeated dose toxicity p.30
Regulatory source repeated dose toxicity =25 mg/kg bw/d rat oral subchronic repeated dose toxicity p.30
Regulatory source repeated dose toxicity 2000 mg/kg bw rat oral developmental repeated dose toxicity p.30
Regulatory source repeated dose toxicity 500 mg/kg bw/d rat oral developmental repeated dose toxicity p.30