Good Cosmetic Ingredient NOAEL Data

Distearyl Ether

INCI: DISTEARYL ETHER

CAS Number
6297-03-6
Function
Skin conditioning (emollient, occlusive)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” not restricted under 21 CFR; no CIR review located

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Distearyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL >1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Low use concentrations reported in industry surveys with no known sensitization, irritation, or systemic toxicity signals.

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Concern Level: Low

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Distearyl Ether safe in cosmetics?

Low use concentrations reported in industry surveys with no known sensitization, irritation, or systemic toxicity signals. The EU classifies Distearyl Ether as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Distearyl Ether allowed in the EU?

Distearyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Distearyl Ether do in cosmetics?

Distearyl Ether functions as: Skin conditioning (emollient, occlusive). It is classified as a cosmetic ingredient in our database. CAS number: 6297-03-6.

What is the Margin of Safety for Distearyl Ether?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Distearyl Ether?

The NOAEL (No Observed Adverse Effect Level) for Distearyl Ether is >1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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