Dithiodiethyl Bis-Salicylamide

INCI: DITHIODIETHYL BIS-SALICYLAMIDE

CAS Number
PubChem CID 71548479 — CAS requires verification against CosIng/ECHA
Function
Skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted - not listed under 21 CFR 700.15 (which bans halogenated salicylanilides specifically)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Salicylamide backbone warrants comparison to salicylic acid absorption data; disulfide bond presents thiol-exchange concern; phenolic OH groups may interact with oxidizing preservative systems; essentially zero published cosmetic safety data.

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Concern Level: Moderate

Frequently Asked Questions

Is Dithiodiethyl Bis-Salicylamide safe in cosmetics?

Salicylamide backbone warrants comparison to salicylic acid absorption data; disulfide bond presents thiol-exchange concern; phenolic OH groups may interact with oxidizing preservative systems; essentially zero published cosmetic safety data. The EU classifies Dithiodiethyl Bis-Salicylamide as "prohibited". Safety rating: MODERATE.

Is Dithiodiethyl Bis-Salicylamide allowed in the EU?

Dithiodiethyl Bis-Salicylamide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Dithiodiethyl Bis-Salicylamide do in cosmetics?

Dithiodiethyl Bis-Salicylamide functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: PubChem CID 71548479 — CAS requires verification against CosIng/ECHA.

What is the Margin of Safety for Dithiodiethyl Bis-Salicylamide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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