Good Cosmetic Ingredient NOAEL Data

Ditridecyl Adipate

INCI: DITRIDECYL ADIPATE

CAS Number
16958-92-2
Function
Emollient, skin conditioning agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted, not listed as prohibited or restricted under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Ditridecyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 630 mg/kg bw/day oral rat oral REACH
NOAEL 2000 mg/kg bw/day dermal rat dermal REACH
NOAEL 200 mg/kg bw/day oral mouse oral REACH
NOAEL 200 mg/kg bw/day oral rat oral REACH
NOAEL 178 mg/kg bw/day oral rat oral REACH

Expert Verdict

High molecular weight ester with negligible absorption. Ester hydrolysis releases tridecyl alcohol and adipic acid, both low-toxicity metabolites. Confirm purity specifications for residual catalysts in sensitive formulations.

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Concern Level: Low

Frequently Asked Questions

Is Ditridecyl Adipate safe in cosmetics?

High molecular weight ester with negligible absorption. Ester hydrolysis releases tridecyl alcohol and adipic acid, both low-toxicity metabolites. Confirm purity specifications for residual catalysts in sensitive formulations. The EU classifies Ditridecyl Adipate as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.

Is Ditridecyl Adipate allowed in the EU?

Ditridecyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ditridecyl Adipate do in cosmetics?

Ditridecyl Adipate functions as: Emollient, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 16958-92-2.

What is the Margin of Safety for Ditridecyl Adipate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ditridecyl Adipate?

The NOAEL (No Observed Adverse Effect Level) for Ditridecyl Adipate is 630 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.

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