NOAEL Studies
Cosmetic Ingredient
DMSO NOAEL Studies
CAS: 67-68-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =1000 | mg/kg bw/day | Rat | oral: gavage | - | other | EFSA FEEDAP - 2013 - OutputID 2224 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3208 |
| EFSA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | repeat dose other | LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species. doi:10.2903/j.efsa.2013.3208.; TITLE=Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3208; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15622445:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_896433cfa5f2660df5bdbebf1b8309dc |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =14500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10239; row=3980; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl sulfoxide; preferred_name=Dimethyl sulfoxide; dtxsid=DTXSID2021735; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021735; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =28300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_10241; row=3981; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl sulfoxide; preferred_name=Dimethyl sulfoxide; dtxsid=DTXSID2021735; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021735; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=8296; RecordID=ARPathway2016_1473; DatasetName=ARPathway2016; DTXSID=DTXSID2021735; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
NTP ICE eye irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 7.3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=765; Record_ID=eye_irritation_187; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=7.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=763; Record_ID=eye_irritation_187; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE eye irritation | Intensity | 0.11 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=767; Record_ID=eye_irritation_1248; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Vitrigel; Endpoint=Intensity; Response=0.11; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE eye irritation | Lag time | >180 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=766; Record_ID=eye_irritation_1248; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE eye irritation | Plateau level | 0 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=769; Record_ID=eye_irritation_1248; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
NTP ICE skin irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Positive reaction | 100 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=536; Record_ID=skin_irritation_invivo_5; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=100; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
NTP ICE skin sensitization 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 4894.5 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2416; Record_ID=skin_sensitization_invitro_586; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=4894.5200000000004; Reported_Response_Unit=ug/mL; Response=4894.5; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | CD86, EC150 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8705; Record_ID=skin_sensitization_invitro_2411; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | CV75 | 5000 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2418; Record_ID=skin_sensitization_invitro_586; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=h-CLAT; Endpoint=CV75; Reported_Response=5000; Reported_Response_Unit=ug/mL; Response=5000; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6526; Record_ID=skin_sensitization_invitro_1543; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | EC3 | 72 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13139; Record_ID=skin_sensitization_invivo_3156; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=LLNA; Endpoint=EC3; Response=72; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | Imax | 1.23 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6531; Record_ID=skin_sensitization_invitro_1543; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.23; Reported_Response_Unit=Unitless; Response=1.23; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9387; Record_ID=skin_sensitization_invivo_2081; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=75.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | Induction dose per skin area | 46550 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9385; Record_ID=skin_sensitization_invivo_2081; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=75.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=46550; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9391; Record_ID=skin_sensitization_invivo_2081; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=75.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021735; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021735; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021735 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =83083.4 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15514746:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a7badbd63efe2c44e041c2ee9e38fa01 |
ECHA 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =1800 | mg/kg bw/day | Mouse | injection | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d21711d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/8?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15819097:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_39162129a3e148e952c14969ec31e145 |
| ECHA | LOAEC | =5380 | mg/m3 | Rat | inhalation | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/3?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829492_15829493:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_762830d26a98ca048829c59b67fd54fb |
| ECHA | LOAEL | =660 | mg/kg bw/day | Dog | dermal | chronic; 26 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e5ce4b096bca8779642; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826487_15826488:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6198aed442ecde6014c929877ff54555 |
| ECHA | LOAEL | =750 | mg/kg bw/day | Rat | injection | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d21883e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/10/1?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15826012_15826013:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ce93ce52c97b0b9512c9cd9e68f7214 |
| ECHA | LOAEL | =990 | mg/kg bw/day | Monkey | dermal | chronic; 18 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61dc5e4b096bca8777152; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826312_15826313:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db96247e1a2feca7cbb1b3655af892b1 |
| ECHA | LOAEL | =1650 | mg/kg bw/day | Rabbit | dermal | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61da4e4b096bca87768ec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826261_15826262_15826263:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c26a92653147e4c5388bd4d9b024b6b |
| ECHA | LOAEL | =2970 | mg/kg bw/day | Pig | dermal | chronic; 58 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f07e4b096bca877c02e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826711_15826712_15826713:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_45bd9c8ed8f485cedcf45dd8f7845f18 |
| ECHA | LOAEL | =4950 | mg/kg bw/day | Rabbit | dermal | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61da4e4b096bca87768ec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826261_15826262_15826263:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_590ef8a4e94ec23bed371a269231f596 |
| ECHA | LOAEL | =5000 | mg/kg bw/day | Rabbit | dermal | short-term; 30 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e8ee4b096bca877a1e5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826547_15826548:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_12694181bc5072efc05fc8304d8a5047 |
| ECHA | LOAEL | =8910 | mg/kg bw/day | Monkey | oral | chronic; 18 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb88e4b0a7c65d2268be; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/2?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833311_15833312:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b7f566570f5784f3c6e18fd5ff323e3e |
| ECHA | LOAEL | =9900 | mg/kg bw/day | Rat | oral | chronic; 18 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea4e4b0a7c65d1ca2ac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/2?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830553_15849699:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_12308169fd6bd1f0bf059bb6bf1a9768 |
| ECHA | LOAEL | =11000 | mg/kg bw/day | Monkey | dermal | chronic; 200 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61db5e4b096bca8776c45; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826270_15826271_15826272:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c425f183a10a33af0a6345432f9a9b4 |
| ECHA | NOAEC | =964 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fe3e4b096bca877f33e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/3?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827120_15827121_15827122:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b31986bd7b36cca989cf8feb9f217cb1 |
| ECHA | NOAEC | =1390 | mg/m3 | Rat | inhalation | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/3?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829492_15829493:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d26a9e8a5c69cb7ff9b2d18d444069c3 |
| ECHA | NOAEC | =2783 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fe3e4b096bca877f33e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/3?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827120_15827121_15827122:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7467fb952f9833537c0ff42ff15eb01b |
| ECHA | NOAEC | =2793 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d21883c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/10/1?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15825856:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0572ca25aae2c0e77a4dbaa4b116f1f0 |
| ECHA | NOAEC | >2800 | mg/m3 | Rat | inhalation | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217ea0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/10/2?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15825495:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_023e56a347cde7c7ca8ebece54084cd3 |
| ECHA | NOAEL | <300 | mg/kg bw/day | Dog | injection | - | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c620ace4b096bca8782457; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/5?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15853750:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ebd1849b252e66040feb2c57de0d975f |
| ECHA | NOAEL | =500 | mg/kg bw/day | Rat | injection | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c86ee4b0a7c65d21883e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/10/1?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15826012_15826013:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e97824621f120c153ce975f5940f290e |
| ECHA | NOAEL | =825 | mg/kg bw/day | Pig | dermal | chronic; 123 days | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f07e4b096bca877c088; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15826717:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e95ec2b00e07389862976071c4aab52 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be618; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/9/3?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823228_15823414:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a8774a3601fd93f90be94ca20d10d463 |
| ECHA | NOAEL | =1100 | mg/kg bw/day | Dog | dermal | chronic; 118 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e8ee4b096bca877a18f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826539_15826540_15826541_15826542_15826543:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ac03afe20e15cd2edd17a6976a9836a |
| ECHA | NOAEL | =1650 | mg/kg bw/day | Pig | dermal | chronic; 58 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f07e4b096bca877c02e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826711_15826712_15826713:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_443abf0e837b426edf7da82bb0301837 |
| ECHA | NOAEL | =2200 | mg/kg bw/day | Rabbit | dermal | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f3be4b096bca877cbd6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15826774:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96b3a8ae97d9fc27f7d3406994bd3fd3 |
| ECHA | NOAEL | =2970 | mg/kg bw/day | Rabbit | dermal | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61da4e4b096bca87768ec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826261_15826262_15826263:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2be88754432f4d466fdbd9677b2f86b9 |
| ECHA | NOAEL | =3300 | mg/kg bw/day | Monkey | dermal | chronic; 200 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61db5e4b096bca8776c45; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826270_15826271_15826272:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d68be6b3f30d8b04958025f824ee2cb |
| ECHA | NOAEL | >=6600 | mg/kg bw/day | Dog | dermal | chronic; 26 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e5ce4b096bca8779642; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826487_15826488:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e26b1f1ad1e9b0e6cdfb43ff061ada98 |
| ECHA | NOAEL | >=8910 | mg/kg bw/day | Monkey | dermal | chronic; 18 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61dc5e4b096bca8777152; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15007/7/6/4?documentUUID=bc6f2c12-4157-4caf-bd64-09bb9564b95c; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826312_15826313:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_063f68fe6a394727e3cb6a8810bfd1be |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =25 | uL | Mouse | dermal | short-term; 3 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605855_15607183:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=414ef07ce1357a36587fd998ba108c31 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =17.67 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631482_15631483:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b1fbf93fc05ee0e33b62a99e5022171 |
| ToxValDB GESTIS DNEL | DNEL systemic | =75 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631482_15631483:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f400a6afbd105be8e929b0e1a9ee53de |
ToxValDB HPVIS 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEC | =2.783 | mg/L | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF="need to add"; QUALITY=1; EXTERNAL_SOURCE_ID=62468; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639303_15639331:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11378708a9ac79449a252f1511cc5507 |
| ToxValDB HPVIS | LOAEL | =2000 | mg/kg bw/day | Mouse | oral | short-term; 3 weeks | short-term | LONG_REF=Caujolle F (1969) Rapport sur la toxicite du dimethylsulfoxyde. Faculte de Medecine et de Pharmacie de Toulouse. 12 mai 1969.; TITLE=Rapport sur la toxicite du dimethylsulfoxyde; AUTHOR=Caujolle F; QUALITY=3; EXTERNAL_SOURCE_ID=62467; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=HPVIS:15639302:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2944b995894608c91c85288d5f90b6d4 |
| ToxValDB HPVIS | LOAEL | =2500 | mg/kg bw/day | Dog | oral | chronic; 23 weeks | chronic | LONG_REF=Rubin, L.F. and Bamett, K.C. (1967) Ocular effects of oral and dermal application of dimethyl sulfoxide in animals, Ann. N.-Y. Acad. Sci., 141, 333-345.; TITLE=Ocular effects of oral and dermal application of dimethyl sulfoxide in animals; AUTHOR=Rubin, L.F. and Bamett, K.C; QUALITY=3; EXTERNAL_SOURCE_ID=63789; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=HPVIS:15639443:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_91a7756f75d5ad05e6435f1352ce91ec |
| ToxValDB HPVIS | NOAEC | =0.2 | mg/L | Rat | inhalation | subchronic; 6 weeks | subchronic | LONG_REF=Fishman EG, Jenkins LJ, Coon RA and Jones RA (1969) Effects of acute and repeated inhalation of dimethyl sulfoxide in rats. Toxicol. Appl. Pharmacol., 15, 74-82.; TITLE=Effects of acute and repeated inhalation of dimethyl sulfoxide in rats; AUTHOR=Fishman EG, Jenkins LJ, Coon RA and Jones RA; QUALITY=3; EXTERNAL_SOURCE_ID=63267; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=HPVIS:15639387:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2c9b685aaf0b2193a643e10396bc648 |
| ToxValDB HPVIS | NOAEC | =0.964 | mg/L | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF="need to add"; QUALITY=1; EXTERNAL_SOURCE_ID=62750; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639303_15639331:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b9d499a08782c6b49c9d4157bd5924c6 |
| ToxValDB HPVIS | NOAEL | =1100 | mg/kg bw/day | Rat | oral | chronic; 18 months | chronic | LONG_REF=Noel, P. R. B., Barnett, K. C., Davies, R. E., Jolly, D. W.. Leahy, J. S., Mawdesley-Thomas, L. E.. Shillam, K. W. G., Squires, P. F., Street, A. E.. Tucker, W. C., Worden, A. N. (1975) The toxicity of dimethyl sulphoxide (DMSO) for the dog, pig, rat and rabbit. Toxicology, 3 (2), 143-69.; TITLE=The toxicity of dimethyl sulphoxide (DMSO) for the dog, pig, rat and rabbit; AUTHOR=Noel, P. R. B., Barnett, K. C., Davies, R. E., Jolly, D. W.. Leahy, J. S., Mawdesley-Thomas, L. E.. Shillam, K. W. G., Squires, P. F., Street, A. E.. Tucker, W. C., Worden, A. N; QUALITY=3; EXTERNAL_SOURCE_ID=61721; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640248_15640252:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9cdbee3ab3453c9392c5cce33f6c4f29 |
| ToxValDB HPVIS | NOAEL | <2000 | mg/kg bw/day | Rat | injection | short-term; 10 days | reproduction developmental | LONG_REF=von Kreutz, R. and Wendler (1977) Embryotoxizitlt von Dimethylsulfoxid (DMSO), Zbl. Pharm., 116/2, 131-137.; TITLE=Embryotoxizitlt von Dimethylsulfoxid (DMSO); AUTHOR=von Kreutz, R. and Wendler; QUALITY=3; EXTERNAL_SOURCE_ID=57821; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS:15642268:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0a0f793cf74238eb83332ba4a8243d0 |
| ToxValDB HPVIS | NOAEL | =2500 | mg/kg bw/day | Mouse | injection | subchronic; 5 weeks | subchronic | LONG_REF=Caujolle F (1969) Rapport sur la toxicite du dimethylsulfoxyde. Faculte de Medecine et de Pharmacie de Toulouse. 12 mai 1969.Caujolle. F., Caujolle, D., Bouissou, H. and Calvet. M. M. (1964) Toxicity and pharmacologic capability of dimethyl sulfoxide, C. R. Acad. Sci. Paris, 258. 2224-2226.; QUALITY=3; EXTERNAL_SOURCE_ID=62216; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1969; ORIGINAL_YEAR=1969; STUDY_GROUP=HPVIS:15639276:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_39df49d8d7d64f25e26ab6b3ad6eb750 |
| ToxValDB HPVIS | NOAEL | =4000 | mg/kg bw/day | Rabbit | injection | - | developmental | LONG_REF=Caujolle, F., Caujolle, D., Cros. S.. Calvet, M. et Tollon, Y. (1965) Pouvoir teratogene du dimethylsulfoxyde et du diethylsulfoxyde, CR. Acad. Sci. Paris, 260, 327-330.; TITLE=Pouvoir teratogene du dimethylsulfoxyde et du diethylsulfoxyde; AUTHOR=Caujolle, F., Caujolle, D., Cros. S.. Calvet, M. et Tollon, Y; QUALITY=3; EXTERNAL_SOURCE_ID=57822; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1965; ORIGINAL_YEAR=1965; STUDY_GROUP=HPVIS:15642269:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b6fe0c9e8450825d89e01523f7b20e5d |
| ToxValDB HPVIS | NOAEL | =5000 | mg/kg bw/day | Rabbit | oral | short-term; 9 days | developmental | LONG_REF=Caujolle, F. M., Caujolle, D. H., Cros, S. B., Calvet, M. M. (1967) Limits of toxic and teratogenic tolerance of dimethyl sulfoxide. Ann. N-Y. Acad. Sci., 141 (1) 110-26.; TITLE=Limits of toxic and teratogenic tolerance of dimethyl sulfoxide; AUTHOR=Caujolle, F. M., Caujolle, D. H., Cros, S. B., Calvet, M. M; QUALITY=3; EXTERNAL_SOURCE_ID=59777; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=HPVIS:15642857:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c5215a19047e6c1496a720ac946ce1ac |
| ToxValDB HPVIS | NOAEL | <5500 | mg/kg bw/day | Hamster | injection | acute; 1 days | reproduction developmental | LONG_REF=Fen, V. H. (1966) Teratogenic effect of dimethyl sulphoxide. Lancet, 1 (430), 208-9.; TITLE=Teratogenic effect of dimethyl sulphoxide; AUTHOR=Fen, V. H; QUALITY=3; EXTERNAL_SOURCE_ID=59378; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1966; ORIGINAL_YEAR=1966; STUDY_GROUP=HPVIS:15642735:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_908f7c650b46e2e1c148869278334ba4 |
| ToxValDB HPVIS | NOAEL | =10000 | mg/kg bw/day | Rat | oral | short-term; 6 days | reproduction developmental | LONG_REF=Caujolle, F. M., Caujolle, D. H., Cros, S. B., Calvet, M. M. (1967) Limits of toxic and teratogenic tolerance of dimethyl sulfoxide. Ann. N-Y. Acad. Sci., 141 (1) 110-26.; TITLE=Limits of toxic and teratogenic tolerance of dimethyl sulfoxide; AUTHOR=Caujolle, F. M., Caujolle, D. H., Cros, S. B., Calvet, M. M; QUALITY=3; EXTERNAL_SOURCE_ID=60155; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=HPVIS:15642997:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7ea304d887f32e1a83ff8e1b8d4f126 |
| ToxValDB HPVIS | NOAEL | <10250 | mg/kg bw/day | Rat | injection | acute; 1 days | developmental | LONG_REF=Juma, M. B. and Staples, R. E. (1967) Effect of maternal administration of Dimethyl Sulfoxide on the development of rat fetuses, Proc. Sot. Exp. Biol. Med., 125, 567-569.; TITLE=Effect of maternal administration of Dimethyl Sulfoxide on the development of rat fetuses; AUTHOR=Juma, M. B. and Staples, R. E; QUALITY=3; EXTERNAL_SOURCE_ID=58570; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=HPVIS:15642497:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1a79320bf8f2583ff94c983d48b8e87 |
| ToxValDB HPVIS | NOAEL | =12000 | mg/kg bw/day | Mouse | oral | short-term; 7 days | developmental | LONG_REF=Caujolle, F. M., Caujolle, D. H., Cros, S. B., Calvet, M. M. (1967) Limits of toxic and teratogenic tolerance of dimethyl sulfoxide. Ann. N-Y. Acad. Sci., 141 (1) 110-26.; TITLE=Limits of toxic and teratogenic tolerance of dimethyl sulfoxide; AUTHOR=Caujolle, F. M., Caujolle, D. H., Cros, S. B., Calvet, M. M; QUALITY=3; EXTERNAL_SOURCE_ID=57817; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1967; ORIGINAL_YEAR=1967; STUDY_GROUP=HPVIS:15642266:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2082667d4d36fcc134d9bd4453071fa7 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | YOW8V9698H | UNII | - | - | - | chemical | - |